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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 15

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HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins.
Brumme ZL, John M, Carlson JM, Brumme CJ, Chan D, Brockman MA, Swenson LC, Tao I, Szeto S, Rosato P, Sela J, Kadie CM, Frahm N, Brander C, Haas DW, Riddler SA, Haubrich R, Walker BD, Harrigan PR, Heckerman D, Mallal S
(2009) PLoS One 4: e6687
MeSH Terms: Amino Acid Sequence, Cohort Studies, Gene Products, gag, Gene Products, nef, Gene Products, pol, Genotype, HIV Infections, HIV-1, HLA Antigens, Humans, Immune Evasion, Molecular Sequence Data
Added March 13, 2015
0 Communities
1 Members
0 Resources
12 MeSH Terms
Selective restriction of Nef-defective human immunodeficiency virus type 1 by a proteasome-dependent mechanism.
Qi M, Aiken C
(2007) J Virol 81: 1534-6
MeSH Terms: Cysteine Endopeptidases, Gene Products, nef, HIV-1, Humans, Proteasome Endopeptidase Complex, nef Gene Products, Human Immunodeficiency Virus
Added February 19, 2015
0 Communities
1 Members
0 Resources
6 MeSH Terms
HIV-1 genes vpr and nef synergistically damage podocytes, leading to glomerulosclerosis.
Zuo Y, Matsusaka T, Zhong J, Ma J, Ma LJ, Hanna Z, Jolicoeur P, Fogo AB, Ichikawa I
(2006) J Am Soc Nephrol 17: 2832-43
MeSH Terms: AIDS-Associated Nephropathy, Animals, Female, Gene Products, nef, Genes, vpr, Glomerulosclerosis, Focal Segmental, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Podocytes, nef Gene Products, Human Immunodeficiency Virus
Added January 25, 2012
2 Communities
2 Members
0 Resources
12 MeSH Terms
HIV-1 Nef mediates post-translational down-regulation and redistribution of the mannose receptor.
Vigerust DJ, Egan BS, Shepherd VL
(2005) J Leukoc Biol 77: 522-34
MeSH Terms: Amino Acid Sequence, Base Sequence, Cell Line, Flow Cytometry, Gene Products, nef, HIV-1, HeLa Cells, Humans, Lectins, C-Type, Macrophages, Mannose Receptor, Mannose-Binding Lectins, Molecular Sequence Data, Mutagenesis, Site-Directed, Oligonucleotide Probes, Protein Processing, Post-Translational, Receptors, Cell Surface, Recombinant Fusion Proteins, Transfection, nef Gene Products, Human Immunodeficiency Virus
Added March 22, 2016
0 Communities
1 Members
0 Resources
20 MeSH Terms
Nef stimulates human immunodeficiency virus type 1 replication in primary T cells by enhancing virion-associated gp120 levels: coreceptor-dependent requirement for Nef in viral replication.
Lundquist CA, Zhou J, Aiken C
(2004) J Virol 78: 6287-96
MeSH Terms: CD4 Antigens, CD4-Positive T-Lymphocytes, Cells, Cultured, Down-Regulation, Gene Products, nef, HIV Envelope Protein gp120, HIV Envelope Protein gp41, HIV-1, Humans, Receptors, CXCR4, Virion, Virus Replication, nef Gene Products, Human Immunodeficiency Virus
Added February 19, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
Nef does not affect the efficiency of human immunodeficiency virus type 1 fusion with target cells.
Tobiume M, Lineberger JE, Lundquist CA, Miller MD, Aiken C
(2003) J Virol 77: 10645-50
MeSH Terms: CD4 Antigens, Gene Products, nef, HIV-1, HeLa Cells, Humans, Membrane Fusion, Virion, nef Gene Products, Human Immunodeficiency Virus
Added February 19, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms
Disassembly of human immunodeficiency virus type 1 cores in vitro reveals association of Nef with the subviral ribonucleoprotein complex.
Forshey BM, Aiken C
(2003) J Virol 77: 4409-14
MeSH Terms: Cell Line, Gene Products, nef, Genes, nef, HIV-1, Humans, In Vitro Techniques, Microscopy, Electron, Mutation, Ribonucleoproteins, Viral Core Proteins, Viral Proteins, nef Gene Products, Human Immunodeficiency Virus
Added February 19, 2015
0 Communities
1 Members
0 Resources
12 MeSH Terms
Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes.
Lundquist CA, Tobiume M, Zhou J, Unutmaz D, Aiken C
(2002) J Virol 76: 4625-33
MeSH Terms: CD4 Antigens, CD4-Positive T-Lymphocytes, Down-Regulation, Gene Products, nef, HIV-1, Humans, Virus Replication, nef Gene Products, Human Immunodeficiency Virus
Added February 19, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms
Nef enhances human immunodeficiency virus type 1 infectivity resulting from intervirion fusion: evidence supporting a role for Nef at the virion envelope.
Zhou J, Aiken C
(2001) J Virol 75: 5851-9
MeSH Terms: CD4-Positive T-Lymphocytes, Cell Membrane, Gene Products, nef, HIV-1, HeLa Cells, Humans, Virion, nef Gene Products, Human Immunodeficiency Virus
Added February 19, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms
Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivity.
Chazal N, Singer G, Aiken C, Hammarskjöld ML, Rekosh D
(2001) J Virol 75: 4014-8
MeSH Terms: Animals, Anti-Bacterial Agents, Antibodies, Viral, Cell Line, Gene Deletion, Gene Products, nef, HIV Envelope Protein gp120, HIV-1, HeLa Cells, Humans, Hydrogen-Ion Concentration, Immune Sera, Macrolides, Membrane Fusion, Membrane Glycoproteins, Molecular Sequence Data, Neutralization Tests, Receptors, HIV, Viral Envelope Proteins, nef Gene Products, Human Immunodeficiency Virus
Added February 19, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms