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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 11

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High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML.
Zhao Y, Liu Q, Acharya P, Stengel KR, Sheng Q, Zhou X, Kwak H, Fischer MA, Bradner JE, Strickland SA, Mohan SR, Savona MR, Venters BJ, Zhou MM, Lis JT, Hiebert SW
(2016) Cell Rep 16: 2003-16
MeSH Terms: Antineoplastic Agents, Azepines, Cell Line, Tumor, Chromosomes, Human, Pair 21, Chromosomes, Human, Pair 8, Clustered Regularly Interspaced Short Palindromic Repeats, DNA-Directed RNA Polymerases, Drug Resistance, Neoplasm, Enhancer Elements, Genetic, Gene Expression Regulation, Leukemic, High-Throughput Nucleotide Sequencing, Humans, Leukemia, Myeloid, Acute, MicroRNAs, Multigene Family, Myeloid Cell Leukemia Sequence 1 Protein, Promoter Regions, Genetic, Protein Isoforms, Proteins, Proto-Oncogene Proteins c-kit, Transcription, Genetic, Translocation, Genetic, Triazoles
Added April 6, 2017
0 Communities
1 Members
0 Resources
23 MeSH Terms
LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.
Smith S, Tripathi R, Goodings C, Cleveland S, Mathias E, Hardaway JA, Elliott N, Yi Y, Chen X, Downing J, Mullighan C, Swing DA, Tessarollo L, Li L, Love P, Jenkins NA, Copeland NG, Thompson MA, Du Y, Davé UP
(2014) PLoS One 9: e85883
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Base Sequence, Basic Helix-Loop-Helix Transcription Factors, CD2 Antigens, Carcinogenesis, Cell Line, Tumor, E-Box Elements, Gene Expression Regulation, Leukemic, Homeodomain Proteins, Humans, LIM Domain Proteins, Leukemia, T-Cell, Mice, Mice, Transgenic, Molecular Sequence Data, Neoplasm Proteins, Oncogenes, Penetrance, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Promoter Regions, Genetic, Protein Binding, Proto-Oncogene Proteins, Signal Transduction, Transcription Factors, Transcription, Genetic, Up-Regulation
Added March 5, 2014
0 Communities
2 Members
0 Resources
27 MeSH Terms
Comprehensive genetic analysis of cytarabine sensitivity in a cell-based model identifies polymorphisms associated with outcome in AML patients.
Gamazon ER, Lamba JK, Pounds S, Stark AL, Wheeler HE, Cao X, Im HK, Mitra AK, Rubnitz JE, Ribeiro RC, Raimondi S, Campana D, Crews KR, Wong SS, Welsh M, Hulur I, Gorsic L, Hartford CM, Zhang W, Cox NJ, Dolan ME
(2013) Blood 121: 4366-76
MeSH Terms: Antimetabolites, Antineoplastic, Apoptosis, Cytarabine, Drug Resistance, Neoplasm, Gene Expression Regulation, Leukemic, Genome-Wide Association Study, Genotype, Humans, Leukemia, Myeloid, Acute, Phenotype, Polymorphism, Single Nucleotide, Treatment Outcome
Added February 22, 2016
0 Communities
2 Members
0 Resources
12 MeSH Terms
Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia.
Aue G, Du Y, Cleveland SM, Smith SB, Davé UP, Liu D, Weniger MA, Metais JY, Jenkins NA, Copeland NG, Dunbar CE
(2011) Blood 118: 4674-81
MeSH Terms: Animals, Bone Marrow Transplantation, Cells, Cultured, Disease Models, Animal, Epistasis, Genetic, Gene Expression Profiling, Gene Expression Regulation, Leukemic, HL-60 Cells, Haploinsufficiency, Humans, Leukemia, Myeloid, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microarray Analysis, Proto-Oncogene Proteins, SOXC Transcription Factors, Trans-Activators
Added March 5, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Proleukemic RUNX1 and CBFbeta mutations in the pathogenesis of acute leukemia.
Engel ME, Hiebert SW
(2010) Cancer Treat Res 145: 127-47
MeSH Terms: Cell Transformation, Neoplastic, Core Binding Factor Alpha 2 Subunit, Core Binding Factor beta Subunit, Gene Expression Regulation, Leukemic, Hematopoiesis, Humans, Leukemia, Myeloid, Acute, Mutation, Neoplasm Proteins, Oncogene Proteins, Fusion, Transcription, Genetic, Translocation, Genetic
Added March 7, 2014
1 Communities
1 Members
0 Resources
12 MeSH Terms
Concordant gene expression in leukemia cells and normal leukocytes is associated with germline cis-SNPs.
French D, Yang W, Hamilton LH, Neale G, Fan Y, Downing JR, Cox NJ, Pui CH, Evans WE, Relling MV
(2008) PLoS One 3: e2144
MeSH Terms: Child, Gene Expression Profiling, Gene Expression Regulation, Leukemic, Genotype, Germ-Line Mutation, Humans, Leukocytes, Polymorphism, Single Nucleotide, Precursor Cell Lymphoblastic Leukemia-Lymphoma
Added February 22, 2016
0 Communities
1 Members
0 Resources
9 MeSH Terms
Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53.
Irish JM, Anensen N, Hovland R, Skavland J, Børresen-Dale AL, Bruserud O, Nolan GP, Gjertsen BT
(2007) Blood 109: 2589-96
MeSH Terms: Cells, Cultured, DNA Damage, Electrophoresis, Gel, Two-Dimensional, Gene Expression, Gene Expression Profiling, Gene Expression Regulation, Leukemic, Humans, Leukemia, Myeloid, Acute, Mutation, Phosphorylation, Protein Isoforms, Proto-Oncogene Proteins c-bcl-2, Signal Transduction, Tumor Suppressor Protein p53, Tyrosine, fms-Like Tyrosine Kinase 3
Added February 15, 2013
1 Communities
1 Members
0 Resources
16 MeSH Terms
Expression of cyclooxygenase-2 and prostaglandins by B-1 cells and B-CLL cells.
Phipps RP, Pollock SJ, Kaur K, Kaufman J, Borrello MA, Graf BA, Nazarenko D, Roberts LJ, Morrow JD, Palis J, Ryan DJ, Bennett JM
(2000) Curr Top Microbiol Immunol 252: 293-300
MeSH Terms: Animals, Antibodies, Anti-Idiotypic, B-Lymphocyte Subsets, CD40 Ligand, Cell Differentiation, Cyclooxygenase 1, Cyclooxygenase 2, Dinoprostone, Enzyme Induction, Gene Expression Regulation, Leukemic, Humans, Inflammation, Interferon-gamma, Isoenzymes, Leukemia, Lymphocytic, Chronic, B-Cell, Lipopolysaccharides, Lymphocyte Activation, Macrophages, Membrane Proteins, Mice, Neoplasm Proteins, Neoplastic Stem Cells, Prostaglandin-Endoperoxide Synthases, Prostaglandins, RNA, Messenger, Th2 Cells, Tumor Cells, Cultured
Added December 10, 2013
0 Communities
1 Members
0 Resources
27 MeSH Terms
Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway.
Dai Z, Quackenbush RC, Courtney KD, Grove M, Cortez D, Reuther GW, Pendergast AM
(1998) Genes Dev 12: 1415-24
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Bone Marrow, Cysteine Endopeptidases, Cytoskeletal Proteins, Fusion Proteins, bcr-abl, Gene Expression Regulation, Leukemic, Homeodomain Proteins, Humans, Leukemia, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Mice, Multienzyme Complexes, Neoplasm Proteins, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Proteasome Endopeptidase Complex, Protein Processing, Post-Translational, Proto-Oncogene Proteins c-abl, Proto-Oncogene Proteins pp60(c-src), Tumor Cells, Cultured, Ubiquitins, ras Proteins
Added March 11, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
Transcriptional regulation during myelopoiesis.
Lenny N, Westendorf JJ, Hiebert SW
(1997) Mol Biol Rep 24: 157-68
MeSH Terms: Animals, Gene Expression Regulation, Gene Expression Regulation, Developmental, Gene Expression Regulation, Leukemic, Hematopoiesis, Humans, Leukemia, Myeloid, Acute, Macrophages, Mice, Mice, Knockout, Monocytes, Transcription Factors
Added June 10, 2010
1 Communities
1 Members
0 Resources
12 MeSH Terms