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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 62

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Epidermal growth factor receptor inhibition downregulates -induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis.
Sierra JC, Asim M, Verriere TG, Piazuelo MB, Suarez G, Romero-Gallo J, Delgado AG, Wroblewski LE, Barry DP, Peek RM, Gobert AP, Wilson KT
(2018) Gut 67: 1247-1260
MeSH Terms: Animals, Antineoplastic Agents, Cell Culture Techniques, Epithelial Cells, ErbB Receptors, Gastritis, Gefitinib, Gerbillinae, Helicobacter Infections, Helicobacter pylori, Mice, Mice, Inbred C57BL, Quinazolines, Stomach Neoplasms
Added June 29, 2017
0 Communities
2 Members
0 Resources
14 MeSH Terms
InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma.
Ma Y, Tang N, Thompson RC, Mobley BC, Clark SW, Sarkaria JN, Wang J
(2016) Clin Cancer Res 22: 1767-76
MeSH Terms: Animals, Antineoplastic Agents, Cell Line, Tumor, Disease Models, Animal, Drug Resistance, Neoplasm, ErbB Receptors, Gefitinib, Glioblastoma, Humans, Insulin, Insulin-Like Growth Factor I, Mice, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Quinazolines, Receptor, IGF Type 1, Receptor, Insulin, Signal Transduction, Tumor Burden, Xenograft Model Antitumor Assays
Added April 18, 2017
0 Communities
1 Members
0 Resources
20 MeSH Terms
Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers.
Yu HA, Arcila ME, Rekhtman N, Sima CS, Zakowski MF, Pao W, Kris MG, Miller VA, Ladanyi M, Riely GJ
(2013) Clin Cancer Res 19: 2240-7
MeSH Terms: Adenocarcinoma, Adult, Aged, Aged, 80 and over, Biopsy, CD56 Antigen, DNA Mutational Analysis, Drug Resistance, Neoplasm, ErbB Receptors, Erlotinib Hydrochloride, Female, Gefitinib, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Kaplan-Meier Estimate, Ki-67 Antigen, Lung, Lung Neoplasms, Male, Middle Aged, Mutation, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-met, Quinazolines, Receptor, ErbB-2
Added September 3, 2013
0 Communities
2 Members
0 Resources
26 MeSH Terms
Crizotinib induces PUMA-dependent apoptosis in colon cancer cells.
Zheng X, He K, Zhang L, Yu J
(2013) Mol Cancer Ther 12: 777-86
MeSH Terms: Animals, Antineoplastic Agents, Apoptosis, Apoptosis Regulatory Proteins, Cell Line, Tumor, Colonic Neoplasms, Crizotinib, Drug Synergism, Female, Gefitinib, Gene Expression Regulation, Neoplastic, Humans, Mice, Niacinamide, Phenylurea Compounds, Protein Kinase Inhibitors, Proto-Oncogene Proteins, Pyrazoles, Pyridines, Quinazolines, Sorafenib, Tumor Suppressor Protein p53, Xenograft Model Antitumor Assays
Added July 28, 2015
0 Communities
1 Members
0 Resources
23 MeSH Terms
Strategies for overcoming EGFR resistance in the treatment of advanced-stage NSCLC.
Lovly CM, Horn L
(2012) Curr Treat Options Oncol 13: 516-26
MeSH Terms: Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, Disease-Free Survival, Drug Resistance, Neoplasm, ErbB Receptors, Erlotinib Hydrochloride, Gefitinib, Humans, Lung Neoplasms, Mutation, Protein Kinase Inhibitors, Quinazolines, Treatment Outcome
Added September 3, 2013
0 Communities
3 Members
0 Resources
13 MeSH Terms
Encouragement to submit data of clinical response to EGFR-TKIs in patients with uncommon EGFR mutations.
Yatabe Y, Pao W, Jett JR
(2012) J Thorac Oncol 7: 775-6
MeSH Terms: Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, ErbB Receptors, Female, Gefitinib, Humans, Lung Neoplasms, Male, Mutation, Missense, Quinazolines
Added September 3, 2013
0 Communities
2 Members
0 Resources
10 MeSH Terms
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.
Prahallad A, Sun C, Huang S, Di Nicolantonio F, Salazar R, Zecchin D, Beijersbergen RL, Bardelli A, Bernards R
(2012) Nature 483: 100-3
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Apoptosis, Cell Line, Tumor, Cell Proliferation, Cetuximab, Colorectal Neoplasms, Drug Resistance, Neoplasm, Drug Synergism, Enzyme Activation, ErbB Receptors, Erlotinib Hydrochloride, Feedback, Physiological, Female, Gefitinib, HEK293 Cells, Humans, Indoles, Melanoma, Mice, Protein Kinase Inhibitors, Proto-Oncogene Proteins B-raf, Quinazolines, RNA Interference, Sulfonamides, Vemurafenib, Xenograft Model Antitumor Assays
Added September 27, 2013
1 Communities
0 Members
0 Resources
29 MeSH Terms
Protein expression signatures for inhibition of epidermal growth factor receptor-mediated signaling.
Myers MV, Manning HC, Coffey RJ, Liebler DC
(2012) Mol Cell Proteomics 11: M111.015222
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Blotting, Western, Cell Line, Tumor, Cell Proliferation, Cetuximab, Chromatography, Liquid, Colorectal Neoplasms, Epidermal Growth Factor, ErbB Receptors, Gastritis, Hypertrophic, Gefitinib, Humans, Mice, Neoplasms, Neoplasms, Glandular and Epithelial, Phosphorylation, Prospective Studies, Proteomics, Quinazolines, Signal Transduction, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Transplantation, Heterologous
Added March 5, 2014
1 Communities
3 Members
0 Resources
25 MeSH Terms
EGFR mutant lung cancer.
Gong Y, Pao W
(2012) Curr Top Microbiol Immunol 355: 59-81
MeSH Terms: Animals, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Non-Small-Cell Lung, Clinical Trials as Topic, Drug Resistance, Neoplasm, ErbB Receptors, Erlotinib Hydrochloride, Gefitinib, HSP90 Heat-Shock Proteins, Humans, Molecular Targeted Therapy, Mutation, Protein Kinase Inhibitors, Protein Structure, Tertiary, Quinazolines, Quinolines
Added September 3, 2013
0 Communities
2 Members
0 Resources
17 MeSH Terms
Maintained sensitivity to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer recurring after adjuvant erlotinib or gefitinib.
Oxnard GR, Janjigian YY, Arcila ME, Sima CS, Kass SL, Riely GJ, Pao W, Kris MG, Ladanyi M, Azzoli CG, Miller VA
(2011) Clin Cancer Res 17: 6322-8
MeSH Terms: Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Chemotherapy, Adjuvant, Drug Resistance, Neoplasm, ErbB Receptors, Erlotinib Hydrochloride, Gefitinib, Humans, Lung Neoplasms, Middle Aged, Mutation, Protein Kinase Inhibitors, Quinazolines, Recurrence
Added March 24, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms