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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 24

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Physiological roles for neuromodulation via G GPCRs working through Gβγ-SNARE interaction.
Hamm HE, Alford ST
(2020) Neuropsychopharmacology 45: 221
MeSH Terms: Animals, Calcium, GTP-Binding Protein alpha Subunits, Gi-Go, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Humans, Neurotransmitter Agents, Protein Binding, SNARE Proteins
Added March 24, 2020
0 Communities
1 Members
0 Resources
9 MeSH Terms
Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.
Zurawski Z, Thompson Gray AD, Brady LJ, Page B, Church E, Harris NA, Dohn MR, Yim YY, Hyde K, Mortlock DP, Jones CK, Winder DG, Alford S, Hamm HE
(2019) Sci Signal 12:
MeSH Terms: Animals, Calcium, Exocytosis, GTP-Binding Protein alpha Subunits, Gi-Go, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Knockout, Neural Inhibition, Phenotype, Protein Binding, Receptors, G-Protein-Coupled, Synaptic Transmission, Synaptosomal-Associated Protein 25
Added February 22, 2019
1 Communities
3 Members
0 Resources
15 MeSH Terms
The in vivo specificity of synaptic Gβ and Gγ subunits to the α adrenergic receptor at CNS synapses.
Yim YY, Betke KM, McDonald WH, Gilsbach R, Chen Y, Hyde K, Wang Q, Hein L, Hamm HE
(2019) Sci Rep 9: 1718
MeSH Terms: Animals, Central Nervous System, Epinephrine, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Gene Knock-In Techniques, Mice, Proteomics, Receptors, Adrenergic, alpha-2, Signal Transduction, Synapses
Added March 24, 2020
0 Communities
1 Members
0 Resources
11 MeSH Terms
Quantitative Multiple-Reaction Monitoring Proteomic Analysis of Gβ and Gγ Subunits in C57Bl6/J Brain Synaptosomes.
Yim YY, McDonald WH, Hyde K, Cruz-Rodríguez O, Tesmer JJG, Hamm HE
(2017) Biochemistry 56: 5405-5416
MeSH Terms: Amino Acid Sequence, Animals, Brain, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Mice, Mice, Inbred C57BL, Protein Multimerization, Protein Structure, Quaternary, Protein Transport, Proteomics, Synaptosomes
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes.
Zurawski Z, Page B, Chicka MC, Brindley RL, Wells CA, Preininger AM, Hyde K, Gilbert JA, Cruz-Rodriguez O, Currie KPM, Chapman ER, Alford S, Hamm HE
(2017) J Biol Chem 292: 12165-12177
MeSH Terms: Animals, Binding, Competitive, Calcium Signaling, Cattle, Cell Line, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Humans, Lipid Bilayers, Liposomes, Membrane Fusion, Models, Molecular, Mutation, Nerve Tissue Proteins, Peptide Fragments, Protein Conformation, Protein Interaction Domains and Motifs, Protein Multimerization, Rats, Recombinant Fusion Proteins, Recombinant Proteins, Synaptosomal-Associated Protein 25, Synaptotagmin I, Syntaxin 1
Added July 12, 2017
0 Communities
2 Members
0 Resources
24 MeSH Terms
A Presynaptic Group III mGluR Recruits Gβγ/SNARE Interactions to Inhibit Synaptic Transmission by Cone Photoreceptors in the Vertebrate Retina.
Van Hook MJ, Babai N, Zurawski Z, Yim YY, Hamm HE, Thoreson WB
(2017) J Neurosci 37: 4618-4634
MeSH Terms: Ambystoma, Animals, Excitatory Postsynaptic Potentials, Female, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Male, Receptors, Metabotropic Glutamate, Retinal Cone Photoreceptor Cells, Retinal Horizontal Cells, SNARE Proteins, Synapses, Synaptic Transmission
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Gβγ Binds to the Extreme C Terminus of SNAP25 to Mediate the Action of Gi/o-Coupled G Protein-Coupled Receptors.
Zurawski Z, Rodriguez S, Hyde K, Alford S, Hamm HE
(2016) Mol Pharmacol 89: 75-83
MeSH Terms: Animals, Cattle, GTP-Binding Protein alpha Subunits, Gi-Go, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Mice, Petromyzon, Protein Binding, Protein Structure, Secondary, Synaptosomal-Associated Protein 25
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Differential stimulation of insulin secretion by GLP-1 and Kisspeptin-10.
Schwetz TA, Reissaus CA, Piston DW
(2014) PLoS One 9: e113020
MeSH Terms: Animals, Blood Glucose, Calcium, Calcium Signaling, GTP-Binding Protein alpha Subunits, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Glucagon-Like Peptide 1, Humans, Insulin, Insulin-Secreting Cells, Islets of Langerhans, Kisspeptins, Male, Mice, Oxidation-Reduction, Signal Transduction
Added January 20, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Differential localization of G protein βγ subunits.
Betke KM, Rose KL, Friedman DB, Baucum AJ, Hyde K, Schey KL, Hamm HE
(2014) Biochemistry 53: 2329-43
MeSH Terms: Amino Acid Sequence, Animals, Chromatography, Liquid, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Male, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Protein Isoforms, Signal Transduction, Subcellular Fractions, Synaptosomes, Tandem Mass Spectrometry
Added May 27, 2014
0 Communities
2 Members
0 Resources
14 MeSH Terms
Gβγ inhibits exocytosis via interaction with critical residues on soluble N-ethylmaleimide-sensitive factor attachment protein-25.
Wells CA, Zurawski Z, Betke KM, Yim YY, Hyde K, Rodriguez S, Alford S, Hamm HE
(2012) Mol Pharmacol 82: 1136-49
MeSH Terms: Alanine, Animals, Binding Sites, Botulinum Toxins, Calcium, Cell Line, Exocytosis, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Lampreys, Mutation, Neurons, Peptides, Protein Binding, Protein Interaction Domains and Motifs, Recombinant Fusion Proteins, SNARE Proteins, Sf9 Cells, Spodoptera, Synaptosomal-Associated Protein 25, Synaptotagmin I, Syntaxin 1
Added December 10, 2013
0 Communities
1 Members
0 Resources
22 MeSH Terms