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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 19

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Comparative analysis of the GNAQ, GNA11, SF3B1, and EIF1AX driver mutations in melanoma and across the cancer spectrum.
Johnson DB, Roszik J, Shoushtari AN, Eroglu Z, Balko JM, Higham C, Puzanov I, Patel SP, Sosman JA, Woodman SE
(2016) Pigment Cell Melanoma Res 29: 470-3
MeSH Terms: Eukaryotic Initiation Factor-1, GTP-Binding Protein alpha Subunits, GTP-Binding Protein alpha Subunits, Gq-G11, Genes, Neoplasm, Humans, Immunotherapy, Melanoma, Mutation, Mutation, Missense, Neoplasms, Phosphoproteins, Point Mutation, Prognosis, RNA Splicing Factors
Added April 6, 2017
0 Communities
1 Members
0 Resources
14 MeSH Terms
A G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways.
Hu J, Stern M, Gimenez LE, Wanka L, Zhu L, Rossi M, Meister J, Inoue A, Beck-Sickinger AG, Gurevich VV, Wess J
(2016) J Biol Chem 291: 7809-20
MeSH Terms: Animals, Arrestins, COS Cells, Calcium, Cells, Cultured, Chlorocebus aethiops, GTP-Binding Protein alpha Subunits, Gq-G11, Gene Knockdown Techniques, Glucose, HEK293 Cells, Hepatocytes, Humans, Mice, Inbred C57BL, Protein Interaction Mapping, Protein Interaction Maps, Receptors, G-Protein-Coupled, Signal Transduction, beta-Arrestins
Added February 15, 2016
0 Communities
1 Members
0 Resources
18 MeSH Terms
Evidence against dopamine D1/D2 receptor heteromers.
Frederick AL, Yano H, Trifilieff P, Vishwasrao HD, Biezonski D, Mészáros J, Urizar E, Sibley DR, Kellendonk C, Sonntag KC, Graham DL, Colbran RJ, Stanwood GD, Javitch JA
(2015) Mol Psychiatry 20: 1373-85
MeSH Terms: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Animals, Corpus Striatum, Dopamine Agonists, Dopamine Antagonists, GTP-Binding Protein alpha Subunits, Gq-G11, Grooming, HEK293 Cells, Humans, Luminescent Proteins, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Molecular, Motor Activity, Nucleus Accumbens, Phosphorylation, Protein Multimerization, Protein Structure, Tertiary, Receptors, Dopamine D1, Receptors, Dopamine D2
Added January 20, 2015
0 Communities
2 Members
0 Resources
22 MeSH Terms
Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamatergic synapses.
Ramikie TS, Nyilas R, Bluett RJ, Gamble-George JC, Hartley ND, Mackie K, Watanabe M, Katona I, Patel S
(2014) Neuron 81: 1111-1125
MeSH Terms: Amygdala, Animals, Calcium, Endocannabinoids, Excitatory Postsynaptic Potentials, G-Protein-Coupled Receptor Kinase 2, GTP-Binding Protein alpha Subunits, Gq-G11, Glutamic Acid, Male, Mice, Mice, Inbred ICR, Neurons, Receptor Protein-Tyrosine Kinases, Receptor, Cannabinoid, CB1, Receptors, Muscarinic, Signal Transduction, Synapses, Synaptic Transmission
Added January 20, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo.
Li JH, Jain S, McMillin SM, Cui Y, Gautam D, Sakamoto W, Lu H, Jou W, McGuinness OP, Gavrilova O, Wess J
(2013) Endocrinology 154: 3539-51
MeSH Terms: Animals, Antidiuretic Hormone Receptor Antagonists, Cells, Cultured, Diabetes Mellitus, Type 2, Enzyme Activators, Female, G-Protein-Coupled Receptor Kinases, GTP-Binding Protein alpha Subunits, Gq-G11, Gluconeogenesis, Glycogenolysis, Hepatocytes, Humans, Hypoglycemic Agents, Male, Mice, Mice, Obese, Mice, Transgenic, Protein Engineering, Protein Interaction Domains and Motifs, Receptor, Muscarinic M3, Receptors, Vasopressin, Recombinant Fusion Proteins, Specific Pathogen-Free Organisms
Added July 21, 2014
1 Communities
1 Members
1 Resources
23 MeSH Terms
High throughput mass spectrometry-based mutation profiling of primary uveal melanoma.
Daniels AB, Lee JE, MacConaill LE, Palescandolo E, Van Hummelen P, Adams SM, DeAngelis MM, Hahn WC, Gragoudas ES, Harbour JW, Garraway LA, Kim IK
(2012) Invest Ophthalmol Vis Sci 53: 6991-6
MeSH Terms: DNA Mutational Analysis, DNA, Neoplasm, GTP-Binding Protein alpha Subunits, GTP-Binding Protein alpha Subunits, Gq-G11, Gene Amplification, Gene Expression Profiling, Humans, Melanoma, Mutation, Oncogenes, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Tumor Suppressor Proteins, Uveal Neoplasms
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials.
Lovly CM, Dahlman KB, Fohn LE, Su Z, Dias-Santagata D, Hicks DJ, Hucks D, Berry E, Terry C, Duke M, Su Y, Sobolik-Delmaire T, Richmond A, Kelley MC, Vnencak-Jones CL, Iafrate AJ, Sosman J, Pao W
(2012) PLoS One 7: e35309
MeSH Terms: Cell Line, Tumor, Clinical Trials as Topic, DNA Mutational Analysis, Eligibility Determination, GTP-Binding Protein alpha Subunits, GTP-Binding Protein alpha Subunits, Gq-G11, Genetic Testing, Humans, Male, Melanoma, Molecular Diagnostic Techniques, Nerve Tissue Proteins, Point Mutation, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-kit, Proto-Oncogene Proteins p21(ras), Skin Neoplasms
Added September 3, 2013
3 Communities
8 Members
0 Resources
17 MeSH Terms
Functional selectivity induced by mGlu₄ receptor positive allosteric modulation and concomitant activation of Gq coupled receptors.
Yin S, Zamorano R, Conn PJ, Niswender CM
(2013) Neuropharmacology 66: 122-32
MeSH Terms: Adenylyl Cyclase Inhibitors, Adenylyl Cyclases, Allosteric Regulation, Animals, Benzopyrans, Calcium, Calcium Signaling, Cell Line, Excitatory Amino Acid Agonists, Excitatory Amino Acid Antagonists, GTP-Binding Protein alpha Subunits, Gq-G11, Glutamic Acid, Guinea Pigs, Histamine, Humans, Phosphatidylinositols, Rats, Receptors, Histamine H1, Receptors, Metabotropic Glutamate, Signal Transduction
Added February 19, 2015
0 Communities
2 Members
0 Resources
20 MeSH Terms
Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress.
McElligott ZA, Klug JR, Nobis WP, Patel S, Grueter BA, Kash TL, Winder DG
(2010) Proc Natl Acad Sci U S A 107: 2271-6
MeSH Terms: Alcoholism, Animals, Ethanol, GTP-Binding Protein alpha Subunits, Gq-G11, Glutamic Acid, Humans, Long-Term Synaptic Depression, Male, Mice, Mice, Inbred C57BL, Neuronal Plasticity, Norepinephrine, Receptor, Angiotensin, Type 1, Receptor, Metabotropic Glutamate 5, Receptors, AMPA, Receptors, Metabotropic Glutamate, Septal Nuclei, Signal Transduction, Stress, Physiological
Added May 19, 2014
0 Communities
2 Members
0 Resources
19 MeSH Terms
Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions.
Peres CM, Aronoff DM, Serezani CH, Flamand N, Faccioli LH, Peters-Golden M
(2007) J Immunol 179: 5454-61
MeSH Terms: Animals, Cells, Cultured, Cyclic AMP, Down-Regulation, Female, GTP-Binding Protein alpha Subunit, Gi2, GTP-Binding Protein alpha Subunits, Gq-G11, GTP-Binding Proteins, Intracellular Fluid, Leukotriene B4, Leukotriene D4, Macrophage Activation, Macrophages, Alveolar, Rats, Rats, Wistar, Receptors, Leukotriene, Toxoids
Added May 4, 2017
0 Communities
1 Members
0 Resources
17 MeSH Terms