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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 33

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Physiological roles for neuromodulation via G GPCRs working through Gβγ-SNARE interaction.
Hamm HE, Alford ST
(2020) Neuropsychopharmacology 45: 221
MeSH Terms: Animals, Calcium, GTP-Binding Protein alpha Subunits, Gi-Go, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Humans, Neurotransmitter Agents, Protein Binding, SNARE Proteins
Added March 24, 2020
0 Communities
1 Members
0 Resources
9 MeSH Terms
Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.
Zurawski Z, Thompson Gray AD, Brady LJ, Page B, Church E, Harris NA, Dohn MR, Yim YY, Hyde K, Mortlock DP, Jones CK, Winder DG, Alford S, Hamm HE
(2019) Sci Signal 12:
MeSH Terms: Animals, Calcium, Exocytosis, GTP-Binding Protein alpha Subunits, Gi-Go, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Knockout, Neural Inhibition, Phenotype, Protein Binding, Receptors, G-Protein-Coupled, Synaptic Transmission, Synaptosomal-Associated Protein 25
Added February 22, 2019
1 Communities
3 Members
0 Resources
15 MeSH Terms
GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation.
Damian M, Pons V, Renault P, M'Kadmi C, Delort B, Hartmann L, Kaya AI, Louet M, Gagne D, Ben Haj Salah K, Denoyelle S, Ferry G, Boutin JA, Wagner R, Fehrentz JA, Martinez J, Marie J, Floquet N, Galès C, Mary S, Hamm HE, Banères JL
(2018) Proc Natl Acad Sci U S A 115: 4501-4506
MeSH Terms: Dopamine, GTP-Binding Protein alpha Subunits, Gi-Go, Humans, Protein Multimerization, Receptors, Dopamine D2, Receptors, Ghrelin, Signal Transduction
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Hepatic Gi signaling regulates whole-body glucose homeostasis.
Rossi M, Zhu L, McMillin SM, Pydi SP, Jain S, Wang L, Cui Y, Lee RJ, Cohen AH, Kaneto H, Birnbaum MJ, Ma Y, Rotman Y, Liu J, Cyphert TJ, Finkel T, McGuinness OP, Wess J
(2018) J Clin Invest 128: 746-759
MeSH Terms: Animals, Blood Glucose, Extracellular Signal-Regulated MAP Kinases, Female, GTP-Binding Protein alpha Subunits, Gi-Go, Gene Expression Profiling, Glucagon, Gluconeogenesis, Glucose, Hepatocytes, Homeostasis, Humans, Liver, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Oxygen, Phosphatidylinositol 3-Kinases, Phosphorylation, Reactive Oxygen Species, Receptors, Glucagon, Signal Transduction
Added March 14, 2018
0 Communities
1 Members
0 Resources
23 MeSH Terms
A Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated Receptor.
Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE
(2016) J Biol Chem 291: 19674-86
MeSH Terms: Enzyme Activation, GTP-Binding Protein alpha Subunits, Gi-Go, Guanosine Diphosphate, Guanosine Triphosphate, Humans, Hydrophobic and Hydrophilic Interactions, Protein Structure, Secondary
Added April 8, 2017
1 Communities
3 Members
0 Resources
7 MeSH Terms
Gβγ Binds to the Extreme C Terminus of SNAP25 to Mediate the Action of Gi/o-Coupled G Protein-Coupled Receptors.
Zurawski Z, Rodriguez S, Hyde K, Alford S, Hamm HE
(2016) Mol Pharmacol 89: 75-83
MeSH Terms: Animals, Cattle, GTP-Binding Protein alpha Subunits, Gi-Go, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Mice, Petromyzon, Protein Binding, Protein Structure, Secondary, Synaptosomal-Associated Protein 25
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
A transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1.
Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM
(2014) J Biol Chem 289: 11331-11341
MeSH Terms: Allosteric Regulation, Amino Acid Substitution, Animals, Crystallography, X-Ray, GTP-Binding Protein alpha Subunits, Gi-Go, Guanosine 5'-O-(3-Thiotriphosphate), Guanosine Diphosphate, Mutation, Missense, Protein Structure, Secondary, Rats
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution.
Preininger AM, Kaya AI, Gilbert JA, Busenlehner LS, Armstrong RN, Hamm HE
(2012) Biochemistry 51: 1911-24
MeSH Terms: Allosteric Regulation, Animals, Deuterium Exchange Measurement, GTP-Binding Protein alpha Subunits, Gi-Go, Models, Molecular, Myristic Acid, Protein Conformation, Rats, Signal Transduction, Solutions
Added December 10, 2013
0 Communities
2 Members
0 Resources
10 MeSH Terms
Suboptimal activation of protease-activated receptors enhances alpha2beta1 integrin-mediated platelet adhesion to collagen.
Marjoram RJ, Voss B, Pan Y, Dickeson SK, Zutter MM, Hamm HE, Santoro SA
(2009) J Biol Chem 284: 34640-7
MeSH Terms: Amino Acid Motifs, Animals, Blood Platelets, Carrier Proteins, Collagen, GTP-Binding Protein alpha Subunits, Gi-Go, Humans, Integrin alpha2beta1, Mice, Mice, Inbred C57BL, Peptides, Platelet Adhesiveness, Platelet Aggregation, Platelet Membrane Glycoproteins, Rats, Receptor, PAR-1, Receptors, Collagen, Receptors, G-Protein-Coupled, Receptors, IgG, Receptors, Thrombin, Signal Transduction, Thrombin, Type C Phospholipases
Added December 10, 2013
1 Communities
2 Members
0 Resources
23 MeSH Terms
Trp fluorescence reveals an activation-dependent cation-pi interaction in the Switch II region of Galphai proteins.
Hamm HE, Meier SM, Liao G, Preininger AM
(2009) Protein Sci 18: 2326-35
MeSH Terms: Arginine, GTP-Binding Protein alpha Subunits, Gi-Go, Guanosine 5'-O-(3-Thiotriphosphate), Guanosine Diphosphate, Kinetics, Models, Molecular, Myristic Acid, Protein Conformation, Protein Structure, Tertiary, Spectrometry, Fluorescence, Tryptophan
Added December 10, 2013
0 Communities
1 Members
0 Resources
11 MeSH Terms