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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 74

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Physiological roles for neuromodulation via G GPCRs working through Gβγ-SNARE interaction.
Hamm HE, Alford ST
(2020) Neuropsychopharmacology 45: 221
MeSH Terms: Animals, Calcium, GTP-Binding Protein alpha Subunits, Gi-Go, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Humans, Neurotransmitter Agents, Protein Binding, SNARE Proteins
Added March 24, 2020
0 Communities
1 Members
0 Resources
9 MeSH Terms
Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.
Zurawski Z, Thompson Gray AD, Brady LJ, Page B, Church E, Harris NA, Dohn MR, Yim YY, Hyde K, Mortlock DP, Jones CK, Winder DG, Alford S, Hamm HE
(2019) Sci Signal 12:
MeSH Terms: Animals, Calcium, Exocytosis, GTP-Binding Protein alpha Subunits, Gi-Go, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Knockout, Neural Inhibition, Phenotype, Protein Binding, Receptors, G-Protein-Coupled, Synaptic Transmission, Synaptosomal-Associated Protein 25
Added February 22, 2019
1 Communities
3 Members
0 Resources
15 MeSH Terms
Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa.
Lokits AD, Indrischek H, Meiler J, Hamm HE, Stadler PF
(2018) BMC Evol Biol 18: 51
MeSH Terms: Animals, DNA-Binding Proteins, Evolution, Molecular, GTP-Binding Protein alpha Subunits, Gene Duplication, Nucleotide Motifs, Phylogeny, Retroelements, Signal Transduction, Vertebrates
Added March 21, 2020
0 Communities
2 Members
0 Resources
MeSH Terms
GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation.
Damian M, Pons V, Renault P, M'Kadmi C, Delort B, Hartmann L, Kaya AI, Louet M, Gagne D, Ben Haj Salah K, Denoyelle S, Ferry G, Boutin JA, Wagner R, Fehrentz JA, Martinez J, Marie J, Floquet N, Galès C, Mary S, Hamm HE, Banères JL
(2018) Proc Natl Acad Sci U S A 115: 4501-4506
MeSH Terms: Dopamine, GTP-Binding Protein alpha Subunits, Gi-Go, Humans, Protein Multimerization, Receptors, Dopamine D2, Receptors, Ghrelin, Signal Transduction
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Hepatic Gi signaling regulates whole-body glucose homeostasis.
Rossi M, Zhu L, McMillin SM, Pydi SP, Jain S, Wang L, Cui Y, Lee RJ, Cohen AH, Kaneto H, Birnbaum MJ, Ma Y, Rotman Y, Liu J, Cyphert TJ, Finkel T, McGuinness OP, Wess J
(2018) J Clin Invest 128: 746-759
MeSH Terms: Animals, Blood Glucose, Extracellular Signal-Regulated MAP Kinases, Female, GTP-Binding Protein alpha Subunits, Gi-Go, Gene Expression Profiling, Glucagon, Gluconeogenesis, Glucose, Hepatocytes, Homeostasis, Humans, Liver, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Oxygen, Phosphatidylinositol 3-Kinases, Phosphorylation, Reactive Oxygen Species, Receptors, Glucagon, Signal Transduction
Added March 14, 2018
0 Communities
1 Members
0 Resources
23 MeSH Terms
A Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated Receptor.
Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE
(2016) J Biol Chem 291: 19674-86
MeSH Terms: Enzyme Activation, GTP-Binding Protein alpha Subunits, Gi-Go, Guanosine Diphosphate, Guanosine Triphosphate, Humans, Hydrophobic and Hydrophilic Interactions, Protein Structure, Secondary
Added April 8, 2017
1 Communities
3 Members
0 Resources
7 MeSH Terms
Comparative analysis of the GNAQ, GNA11, SF3B1, and EIF1AX driver mutations in melanoma and across the cancer spectrum.
Johnson DB, Roszik J, Shoushtari AN, Eroglu Z, Balko JM, Higham C, Puzanov I, Patel SP, Sosman JA, Woodman SE
(2016) Pigment Cell Melanoma Res 29: 470-3
MeSH Terms: Eukaryotic Initiation Factor-1, GTP-Binding Protein alpha Subunits, GTP-Binding Protein alpha Subunits, Gq-G11, Genes, Neoplasm, Humans, Immunotherapy, Melanoma, Mutation, Mutation, Missense, Neoplasms, Phosphoproteins, Point Mutation, Prognosis, RNA Splicing Factors
Added April 6, 2017
0 Communities
1 Members
0 Resources
14 MeSH Terms
A G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways.
Hu J, Stern M, Gimenez LE, Wanka L, Zhu L, Rossi M, Meister J, Inoue A, Beck-Sickinger AG, Gurevich VV, Wess J
(2016) J Biol Chem 291: 7809-20
MeSH Terms: Animals, Arrestins, COS Cells, Calcium, Cells, Cultured, Chlorocebus aethiops, GTP-Binding Protein alpha Subunits, Gq-G11, Gene Knockdown Techniques, Glucose, HEK293 Cells, Hepatocytes, Humans, Mice, Inbred C57BL, Protein Interaction Mapping, Protein Interaction Maps, Receptors, G-Protein-Coupled, Signal Transduction, beta-Arrestins
Added February 15, 2016
0 Communities
1 Members
0 Resources
18 MeSH Terms
Gβγ Binds to the Extreme C Terminus of SNAP25 to Mediate the Action of Gi/o-Coupled G Protein-Coupled Receptors.
Zurawski Z, Rodriguez S, Hyde K, Alford S, Hamm HE
(2016) Mol Pharmacol 89: 75-83
MeSH Terms: Animals, Cattle, GTP-Binding Protein alpha Subunits, Gi-Go, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Mice, Petromyzon, Protein Binding, Protein Structure, Secondary, Synaptosomal-Associated Protein 25
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.
Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD
(2015) Nature 520: 94-8
MeSH Terms: Action Potentials, Agouti-Related Protein, Animals, Eating, Energy Metabolism, Female, GTP-Binding Protein alpha Subunits, Gs, HEK293 Cells, Homeostasis, Humans, Ligands, Male, Melanocortins, Mice, Neurons, Paraventricular Hypothalamic Nucleus, Potassium Channels, Inwardly Rectifying, Receptor, Melanocortin, Type 4, Signal Transduction, alpha-MSH
Added February 4, 2016
0 Communities
2 Members
0 Resources
20 MeSH Terms