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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 5 of 5

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GTP cyclohydrolase I gene polymorphisms are associated with endothelial dysfunction and oxidative stress in patients with type 2 diabetes mellitus.
Wolkow PP, Kosiniak-Kamysz W, Osmenda G, Wilk G, Bujak-Gizycka B, Ignacak A, Kanitkar M, Walus-Miarka M, Harrison DG, Korbut R, Malecki MT, Guzik TJ
(2014) PLoS One 9: e108587
MeSH Terms: 3' Untranslated Regions, Adult, Aged, Alleles, Diabetes Mellitus, Type 2, Endothelium, Vascular, Female, GTP Cyclohydrolase, Genotype, Haplotypes, Humans, Linkage Disequilibrium, Male, Malondialdehyde, Middle Aged, Oxidative Stress, Polymorphism, Single Nucleotide, von Willebrand Factor
Added March 31, 2015
1 Communities
1 Members
0 Resources
18 MeSH Terms
Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension.
Nozik-Grayck E, Woods C, Taylor JM, Benninger RK, Johnson RD, Villegas LR, Stenmark KR, Harrison DG, Majka SM, Irwin D, Farrow KN
(2014) Am J Physiol Lung Cell Mol Physiol 307: L868-76
MeSH Terms: Animals, Blood Pressure, Cyclic GMP, Cyclic Nucleotide Phosphodiesterases, Type 5, Estrogen Antagonists, GTP Cyclohydrolase, Guanylate Cyclase, Hypertension, Pulmonary, Hypertrophy, Right Ventricular, Hypoxia, Lung, Mice, Mice, Knockout, Nitric Oxide Synthase Type III, Pulmonary Artery, Receptors, Cytoplasmic and Nuclear, Signal Transduction, Soluble Guanylyl Cyclase, Superoxide Dismutase, Tamoxifen
Added March 31, 2015
1 Communities
2 Members
0 Resources
20 MeSH Terms
Role of increased guanosine triphosphate cyclohydrolase-1 expression and tetrahydrobiopterin levels upon T cell activation.
Chen W, Li L, Brod T, Saeed O, Thabet S, Jansen T, Dikalov S, Weyand C, Goronzy J, Harrison DG
(2011) J Biol Chem 286: 13846-51
MeSH Terms: Animals, Biopterin, CD3 Complex, Cytokines, GTP Cyclohydrolase, Gene Expression Regulation, Enzymologic, Humans, Immunologic Memory, Mice, Mice, Inbred C57BL, Mice, Transgenic, Ovalbumin, Oxygen, Phosphorylation, T-Lymphocytes
Added December 10, 2013
1 Communities
2 Members
0 Resources
15 MeSH Terms
GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide.
Li L, Rezvan A, Salerno JC, Husain A, Kwon K, Jo H, Harrison DG, Chen W
(2010) Circ Res 106: 328-36
MeSH Terms: Animals, Binding Sites, Biopterin, Blotting, Western, Carotid Arteries, Casein Kinase II, Cell Line, Cells, Cultured, Endothelial Cells, Enzyme Inhibitors, GTP Cyclohydrolase, Humans, Intracellular Signaling Peptides and Proteins, Mice, Mice, Inbred C57BL, Mutation, NG-Nitroarginine Methyl Ester, Nitric Oxide, Nitric Oxide Synthase Type III, Phosphorylation, RNA Interference, Stress, Mechanical
Added December 10, 2013
1 Communities
1 Members
0 Resources
22 MeSH Terms
Regulation of tetrahydrobiopterin biosynthesis by shear stress.
Widder JD, Chen W, Li L, Dikalov S, Thöny B, Hatakeyama K, Harrison DG
(2007) Circ Res 101: 830-8
MeSH Terms: Biopterin, Cells, Cultured, Endothelial Cells, Endothelium, Vascular, GTP Cyclohydrolase, Humans, Mechanotransduction, Cellular, Stress, Physiological
Added February 17, 2016
0 Communities
1 Members
0 Resources
8 MeSH Terms