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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 8 of 8

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VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy.
Nickols HH, Yuh JP, Gregory KJ, Morrison RD, Bates BS, Stauffer SR, Emmitte KA, Bubser M, Peng W, Nedelcovych MT, Thompson A, Lv X, Xiang Z, Daniels JS, Niswender CM, Lindsley CW, Jones CK, Conn PJ
(2016) J Pharmacol Exp Ther 356: 123-36
MeSH Terms: Allosteric Regulation, Animals, Anti-Anxiety Agents, Astrocytes, Behavior, Animal, Brain, Dose-Response Relationship, Drug, Drug Discovery, GABA Agonists, HEK293 Cells, Humans, Inositol Phosphates, MAP Kinase Signaling System, Membrane Potentials, Mice, Mice, Inbred C57BL, Picolinic Acids, Pyridines, Radioligand Assay, Rats, Receptor, Metabotropic Glutamate 5, Synaptic Transmission
Added February 18, 2016
0 Communities
3 Members
0 Resources
22 MeSH Terms
Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in Schizophrenics.
Garcia-Barrantes PM, Cho HP, Niswender CM, Byers FW, Locuson CW, Blobaum AL, Xiang Z, Rook JM, Conn PJ, Lindsley CW
(2015) J Med Chem 58: 7959-71
MeSH Terms: Animals, Central Nervous System, Epilepsy, GABA Agonists, GABA Modulators, Half-Life, Humans, Molecular Conformation, Rats, Receptor, Metabotropic Glutamate 5, Receptors, Metabotropic Glutamate, Schizophrenia, Structure-Activity Relationship
Added February 18, 2016
0 Communities
3 Members
0 Resources
13 MeSH Terms
NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus.
Zhu L, Polley N, Mathews GC, Delpire E
(2008) Epilepsy Res 79: 201-12
MeSH Terms: 4-Aminopyridine, Animals, Blotting, Western, Chlorides, Electrophysiology, Extracellular Space, GABA Agonists, Genotype, Hippocampus, In Vitro Techniques, Mice, Mice, Knockout, Muscimol, Neuroglia, Patch-Clamp Techniques, Potassium Channel Blockers, Pyramidal Cells, Seizures, Sodium-Potassium-Chloride Symporters, Solute Carrier Family 12, Member 2, Symporters
Added August 13, 2010
1 Communities
0 Members
0 Resources
21 MeSH Terms
Binding of muscimol-conjugated quantum dots to GABAC receptors.
Gussin HA, Tomlinson ID, Little DM, Warnement MR, Qian H, Rosenthal SJ, Pepperberg DR
(2006) J Am Chem Soc 128: 15701-13
MeSH Terms: Animals, Binding Sites, Cadmium Compounds, Cells, Cultured, Coated Materials, Biocompatible, Fluorescent Dyes, GABA Agonists, Gene Expression Regulation, Models, Chemical, Muscimol, Nanoparticles, Oocytes, Polyethylene Glycols, Quantum Dots, Receptors, Cell Surface, Receptors, GABA, Selenium Compounds, Spectrometry, Fluorescence, Sulfides, Zinc Compounds
Added May 27, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Regulation of cAMP levels in area CA1 of hippocampus by Gi/o-coupled receptors is stimulus dependent in mice.
Vanhoose AM, Ritchie MD, Winder DG
(2004) Neurosci Lett 370: 80-3
MeSH Terms: 8-Hydroxy-2-(di-n-propylamino)tetralin, Adrenergic alpha-Agonists, Adrenergic beta-Agonists, Analysis of Variance, Animals, Baclofen, Brimonidine Tartrate, Calcium, Cyclic AMP, Dopamine Agonists, Drug Interactions, Excitatory Amino Acid Agonists, GABA Agonists, GTP-Binding Protein alpha Subunits, Gi-Go, Hippocampus, In Vitro Techniques, Isoproterenol, Male, Mice, Mice, Inbred C57BL, N-Methylaspartate, Quinoxalines, Quinpirole, Radioimmunoassay, Receptors, G-Protein-Coupled, Receptors, N-Methyl-D-Aspartate, Serotonin Receptor Agonists
Added May 19, 2014
0 Communities
1 Members
0 Resources
27 MeSH Terms
Physiological roles and therapeutic potential of metabotropic glutamate receptors.
Conn PJ
(2003) Ann N Y Acad Sci 1003: 12-21
MeSH Terms: Animals, Cloning, Molecular, GABA Agents, GABA Agonists, GABA Antagonists, Humans, Indicators and Reagents, Nervous System Diseases, Receptors, Metabotropic Glutamate
Added February 19, 2015
0 Communities
1 Members
0 Resources
9 MeSH Terms
Role of Cl- co-transporters in the excitation produced by GABAA receptors in juvenile bovine adrenal chromaffin cells.
Xie Z, Currie KP, Cahill AL, Fox AP
(2003) J Neurophysiol 90: 3828-37
MeSH Terms: Adrenal Glands, Animals, Bicuculline, Calcium, Calcium Channels, Catecholamines, Cats, Cattle, Cells, Cultured, Chromaffin Cells, Electrophysiology, GABA Agonists, GABA Antagonists, Intracellular Fluid, Lanthanum, Membrane Potentials, Muscimol, Patch-Clamp Techniques, Receptors, Cholinergic, Receptors, GABA-A, Symporters
Added March 30, 2013
0 Communities
1 Members
0 Resources
21 MeSH Terms
Estrogen rapidly attenuates a GABAB response in hypothalamic neurons.
Lagrange AH, Wagner EJ, R√łnnekleiv OK, Kelly MJ
(1996) Neuroendocrinology 64: 114-23
MeSH Terms: Animals, Baclofen, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-, Enkephalins, Estradiol, Female, GABA Agonists, GABA Antagonists, Guinea Pigs, Hypothalamus, Neurons, Potassium Channels, Receptors, GABA, Receptors, Opioid, mu, gamma-Aminobutyric Acid
Added August 14, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms