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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 7 of 7

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GRK3 suppresses L-DOPA-induced dyskinesia in the rat model of Parkinson's disease via its RGS homology domain.
Ahmed MR, Bychkov E, Li L, Gurevich VV, Gurevich EV
(2015) Sci Rep 5: 10920
MeSH Terms: Animals, Behavior, Animal, Corpus Striatum, Disease Models, Animal, Dyskinesias, G-Protein-Coupled Receptor Kinase 3, Gene Expression, Gene Knockdown Techniques, Levodopa, Parkinson Disease, Protein Interaction Domains and Motifs, RGS Proteins, RNA Interference, RNA, Small Interfering, Rats, Signal Transduction
Added February 15, 2016
0 Communities
1 Members
0 Resources
16 MeSH Terms
Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder.
Bychkov ER, Ahmed MR, Gurevich VV, Benovic JL, Gurevich EV
(2011) Neurobiol Dis 44: 248-58
MeSH Terms: Adult, Aged, Aged, 80 and over, Arrestins, Cohort Studies, Female, G-Protein-Coupled Receptor Kinase 2, G-Protein-Coupled Receptor Kinase 3, G-Protein-Coupled Receptor Kinase 5, G-Protein-Coupled Receptor Kinases, Humans, Male, Middle Aged, Prefrontal Cortex, Psychotic Disorders, Schizophrenia, Young Adult
Added December 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
Haloperidol and clozapine differentially affect the expression of arrestins, receptor kinases, and extracellular signal-regulated kinase activation.
Ahmed MR, Gurevich VV, Dalby KN, Benovic JL, Gurevich EV
(2008) J Pharmacol Exp Ther 325: 276-83
MeSH Terms: Animals, Arrestins, Brain, Brain Chemistry, Clozapine, Cryoultramicrotomy, Enzyme Activation, Extracellular Signal-Regulated MAP Kinases, G-Protein-Coupled Receptor Kinase 2, G-Protein-Coupled Receptor Kinase 3, G-Protein-Coupled Receptor Kinase 5, G-Protein-Coupled Receptor Kinases, Gene Expression, Haloperidol, Male, Rats, Rats, Sprague-Dawley
Added December 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment.
Ahmed MR, Bychkov E, Gurevich VV, Benovic JL, Gurevich EV
(2008) J Neurochem 104: 1622-36
MeSH Terms: Animals, Arrestins, Basal Ganglia, Dopamine, Dopamine Agents, Dopamine Agonists, G-Protein-Coupled Receptor Kinase 2, G-Protein-Coupled Receptor Kinase 3, G-Protein-Coupled Receptor Kinase 5, G-Protein-Coupled Receptor Kinases, Gene Expression, Levodopa, Medial Forebrain Bundle, Pergolide, Rats, Rats, Sprague-Dawley, Substantia Nigra
Added December 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
Arrestins and two receptor kinases are upregulated in Parkinson's disease with dementia.
Bychkov ER, Gurevich VV, Joyce JN, Benovic JL, Gurevich EV
(2008) Neurobiol Aging 29: 379-96
MeSH Terms: Aged, Aged, 80 and over, Arrestins, Cohort Studies, Dementia, Female, G-Protein-Coupled Receptor Kinase 3, G-Protein-Coupled Receptor Kinase 5, Humans, Male, Middle Aged, Parkinson Disease, Postmortem Changes, Up-Regulation
Added December 10, 2013
0 Communities
1 Members
0 Resources
14 MeSH Terms
mu-Opioid receptors desensitize less rapidly than delta-opioid receptors due to less efficient activation of arrestin.
Lowe JD, Celver JP, Gurevich VV, Chavkin C
(2002) J Biol Chem 277: 15729-35
MeSH Terms: Amino Acid Sequence, Amino Acid Substitution, Animals, Arrestin, Arrestins, Cloning, Molecular, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-, Enkephalin, D-Penicillamine (2,5)-, G-Protein-Coupled Receptor Kinase 3, GTP-Binding Proteins, Kinetics, Mice, Models, Molecular, Mutagenesis, Site-Directed, Oocytes, Phosphoproteins, Phosphorylation, Protein Conformation, Protein-Serine-Threonine Kinases, Receptors, Opioid, delta, Receptors, Opioid, mu, Recombinant Proteins, Threonine, Xenopus laevis
Added December 10, 2013
0 Communities
1 Members
0 Resources
24 MeSH Terms
Threonine 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes.
Celver JP, Lowe J, Kovoor A, Gurevich VV, Chavkin C
(2001) J Biol Chem 276: 4894-900
MeSH Terms: Animals, Arrestins, Dose-Response Relationship, Drug, Down-Regulation, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-, G Protein-Coupled Inwardly-Rectifying Potassium Channels, G-Protein-Coupled Receptor Kinase 3, Mutagenesis, Site-Directed, Oocytes, Phosphothreonine, Potassium Channels, Potassium Channels, Inwardly Rectifying, Protein-Serine-Threonine Kinases, Receptors, Opioid, mu, Transfection, Xenopus, beta-Arrestins
Added December 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms