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Results: 1 to 10 of 14

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Thrombotic microangiopathy as a cause of cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib.
Latifi Y, Moccetti F, Wu M, Xie A, Packwood W, Qi Y, Ozawa K, Shentu W, Brown E, Shirai T, McCarty OJ, Ruggeri Z, Moslehi J, Chen J, Druker BJ, López JA, Lindner JR
(2019) Blood 133: 1597-1606
MeSH Terms: Animals, Aorta, Cardiovascular Diseases, Endothelium, Fusion Proteins, bcr-abl, Humans, Imidazoles, Ischemia, Mice, Mice, Knockout, Platelet Adhesiveness, Protein Kinase Inhibitors, Pyridazines, Thrombotic Microangiopathies, Ventricular Dysfunction, von Willebrand Factor
Added February 24, 2019
0 Communities
1 Members
0 Resources
16 MeSH Terms
Cardiovascular care of patients with chronic myeloid leukemia (CML) on tyrosine kinase inhibitor (TKI) therapy.
Barber MC, Mauro MJ, Moslehi J
(2017) Hematology Am Soc Hematol Educ Program 2017: 110-114
MeSH Terms: Aged, Dasatinib, Female, Fusion Proteins, bcr-abl, Humans, Hypertension, Pulmonary, Imidazoles, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Male, Middle Aged, Protein Kinase Inhibitors, Pyridazines, Pyrimidines
Added April 22, 2018
0 Communities
1 Members
0 Resources
13 MeSH Terms
Tyrosine Kinase Inhibitor-Associated Cardiovascular Toxicity in Chronic Myeloid Leukemia.
Moslehi JJ, Deininger M
(2015) J Clin Oncol 33: 4210-8
MeSH Terms: Aniline Compounds, Antineoplastic Agents, Cardiovascular System, Clinical Trials as Topic, Dasatinib, Fusion Proteins, bcr-abl, Humans, Hypertension, Imatinib Mesylate, Imidazoles, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Molecular Targeted Therapy, Nitriles, Protein Kinase Inhibitors, Pyridazines, Pyrimidines, Quinolines
Added March 6, 2016
0 Communities
1 Members
0 Resources
17 MeSH Terms
Chronic Myelogenous Leukemia, Version 1.2014.
O'Brien S, Radich JP, Abboud CN, Akhtari M, Altman JK, Berman E, DeAngelo DJ, Deininger M, Devine S, Fathi AT, Gotlib J, Jagasia M, Kropf P, Moore JO, Pallera A, Pinilla-Ibarz J, Reddy VV, Shah NP, Smith BD, Snyder DS, Wetzler M, Gregory K, Sundar H, Ntational comprehensive cancer network
(2013) J Natl Compr Canc Netw 11: 1327-40
MeSH Terms: Antineoplastic Agents, Fusion Proteins, bcr-abl, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Prognosis, Protein Kinase Inhibitors
Added March 20, 2014
0 Communities
1 Members
0 Resources
6 MeSH Terms
Cancer-drug discovery and cardiovascular surveillance.
Groarke JD, Cheng S, Moslehi J
(2013) N Engl J Med 369: 1779-81
MeSH Terms: Antineoplastic Agents, Cardiovascular System, Drug Discovery, Fusion Proteins, bcr-abl, Humans, Imidazoles, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Protein Kinase Inhibitors, Protein-Tyrosine Kinases, Pyridazines, Pyrimidines, Vascular Diseases
Added March 4, 2015
0 Communities
1 Members
0 Resources
12 MeSH Terms
Mobilization of Ph chromosome-negative peripheral blood stem cells in a child with chronic myeloid leukemia after imatinib-induced complete molecular remission.
Woods-Swafford W, Vnencak-Jones CL, Loken MR, Manes B, Frangoul H
(2008) Pediatr Blood Cancer 50: 639-41
MeSH Terms: Antineoplastic Agents, Benzamides, Biomarkers, Tumor, Bone Marrow Purging, Child, Filgrastim, Forecasting, Fusion Proteins, bcr-abl, Granulocyte Colony-Stimulating Factor, Hematopoietic Stem Cell Mobilization, Hematopoietic Stem Cells, Humans, Imatinib Mesylate, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Chronic-Phase, Male, Peripheral Blood Stem Cell Transplantation, Piperazines, Protein Kinase Inhibitors, Pyrimidines, Recombinant Proteins, Remission Induction
Added March 27, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
The p38 MAPK pathway mediates the growth inhibitory effects of interferon-alpha in BCR-ABL-expressing cells.
Mayer IA, Verma A, Grumbach IM, Uddin S, Lekmine F, Ravandi F, Majchrzak B, Fujita S, Fish EN, Platanias LC
(2001) J Biol Chem 276: 28570-7
MeSH Terms: Androstadienes, Cell Division, Cell Line, Dose-Response Relationship, Drug, Electrophoresis, Polyacrylamide Gel, Enzyme Activation, Enzyme Inhibitors, Fusion Proteins, bcr-abl, Genistein, Humans, Imidazoles, Immunoblotting, Interferon-alpha, Intracellular Signaling Peptides and Proteins, K562 Cells, MAP Kinase Signaling System, Mitogen-Activated Protein Kinases, Phosphorylation, Protein Serine-Threonine Kinases, Pyridines, Tyrosine, Wortmannin, p38 Mitogen-Activated Protein Kinases
Added March 5, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
Engagement of the CrkL adaptor in interferon alpha signalling in BCR-ABL-expressing cells.
Grumbach IM, Mayer IA, Uddin S, Lekmine F, Majchrzak B, Yamauchi H, Fujita S, Druker B, Fish EN, Platanias LC
(2001) Br J Haematol 112: 327-36
MeSH Terms: Adaptor Proteins, Signal Transducing, DNA-Binding Proteins, Fusion Proteins, bcr-abl, Humans, Immunoblotting, Interferon-alpha, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Milk Proteins, Nuclear Proteins, Phosphorylation, STAT5 Transcription Factor, Signal Transduction, Trans-Activators, Tumor Cells, Cultured
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway.
Dai Z, Quackenbush RC, Courtney KD, Grove M, Cortez D, Reuther GW, Pendergast AM
(1998) Genes Dev 12: 1415-24
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Bone Marrow, Cysteine Endopeptidases, Cytoskeletal Proteins, Fusion Proteins, bcr-abl, Gene Expression Regulation, Leukemic, Homeodomain Proteins, Humans, Leukemia, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Mice, Multienzyme Complexes, Neoplasm Proteins, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Proteasome Endopeptidase Complex, Protein Processing, Post-Translational, Proto-Oncogene Proteins c-abl, Proto-Oncogene Proteins pp60(c-src), Tumor Cells, Cultured, Ubiquitins, ras Proteins
Added March 11, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation.
Reuther JY, Reuther GW, Cortez D, Pendergast AM, Baldwin AS
(1998) Genes Dev 12: 968-81
MeSH Terms: Animals, Apoptosis, Fusion Proteins, bcr-abl, Gene Expression Regulation, Gene Transfer Techniques, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Mice, Mice, Nude, NF-kappa B, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Signal Transduction, Transcriptional Activation, Transfection, Transformation, Genetic, Tumor Cells, Cultured
Added March 11, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms