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Results: 1 to 9 of 9

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Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer.
Formisano L, Lu Y, Servetto A, Hanker AB, Jansen VM, Bauer JA, Sudhan DR, Guerrero-Zotano AL, Croessmann S, Guo Y, Ericsson PG, Lee KM, Nixon MJ, Schwarz LJ, Sanders ME, Dugger TC, Cruz MR, Behdad A, Cristofanilli M, Bardia A, O'Shaughnessy J, Nagy RJ, Lanman RB, Solovieff N, He W, Miller M, Su F, Shyr Y, Mayer IA, Balko JM, Arteaga CL
(2019) Nat Commun 10: 1373
MeSH Terms: Aminopyridines, Animals, Antineoplastic Agents, Hormonal, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Circulating Tumor DNA, Cyclin D1, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Drug Resistance, Neoplasm, Female, Fulvestrant, High-Throughput Nucleotide Sequencing, Humans, MCF-7 Cells, Mice, Mutation, Naphthalenes, Piperazines, Progression-Free Survival, Proportional Hazards Models, Protein Kinase Inhibitors, Purines, Pyrazoles, Pyridines, Quinolines, Quinoxalines, Receptor, Fibroblast Growth Factor, Type 1, Receptor, Fibroblast Growth Factor, Type 2, Receptors, Estrogen, Signal Transduction, Xenograft Model Antitumor Assays
Added April 2, 2019
0 Communities
1 Members
0 Resources
32 MeSH Terms
Intrinsic apoptotic pathway activation increases response to anti-estrogens in luminal breast cancers.
Williams MM, Lee L, Werfel T, Joly MMM, Hicks DJ, Rahman B, Elion D, McKernan C, Sanchez V, Estrada MV, Massarweh S, Elledge R, Duvall C, Cook RS
(2018) Cell Death Dis 9: 21
MeSH Terms: Aniline Compounds, Animals, Apoptosis, Breast Neoplasms, Cell Line, Tumor, Down-Regulation, Estrogen Antagonists, Female, Fulvestrant, Gene Targeting, Humans, Mice, Myeloid Cell Leukemia Sequence 1 Protein, Receptors, Estrogen, Signal Transduction, Sulfonamides, Up-Regulation, bcl-X Protein
Added March 14, 2018
0 Communities
2 Members
0 Resources
18 MeSH Terms
Oestrogen inhibition reverses pulmonary arterial hypertension and associated metabolic defects.
Chen X, Austin ED, Talati M, Fessel JP, Farber-Eger EH, Brittain EL, Hemnes AR, Loyd JE, West J
(2017) Eur Respir J 50:
MeSH Terms: Anastrozole, Animals, Bone Morphogenetic Protein Receptors, Type II, Disease Models, Animal, Echocardiography, Estradiol, Estrogen Antagonists, Female, Fulvestrant, Hemodynamics, Humans, Hypertension, Pulmonary, Insulin Resistance, Lung, Mice, Mice, Knockout, Mutation, Nitriles, Signal Transduction, Tamoxifen, Triazoles
Added March 14, 2018
0 Communities
3 Members
0 Resources
21 MeSH Terms
F-Fluoroestradiol PET/CT Measurement of Estrogen Receptor Suppression during a Phase I Trial of the Novel Estrogen Receptor-Targeted Therapeutic GDC-0810: Using an Imaging Biomarker to Guide Drug Dosage in Subsequent Trials.
Wang Y, Ayres KL, Goldman DA, Dickler MN, Bardia A, Mayer IA, Winer E, Fredrickson J, Arteaga CL, Baselga J, Manning HC, Mahmood U, Ulaner GA
(2017) Clin Cancer Res 23: 3053-3060
MeSH Terms: Adult, Aged, Biomarkers, Pharmacological, Breast Neoplasms, Cinnamates, Dose-Response Relationship, Drug, Estradiol, Estrogen Receptor alpha, Female, Fulvestrant, Humans, Indazoles, Middle Aged, Molecular Imaging, Molecular Targeted Therapy, Positron Emission Tomography Computed Tomography, Receptors, Estrogen, Tamoxifen
Added April 6, 2017
0 Communities
1 Members
0 Resources
18 MeSH Terms
Decreased LRIG1 in fulvestrant-treated luminal breast cancer cells permits ErbB3 upregulation and increased growth.
Morrison MM, Williams MM, Vaught DB, Hicks D, Lim J, McKernan C, Aurisicchio L, Ciliberto G, Simion C, Sweeney C, Cook RS
(2016) Oncogene 35: 1143-52
MeSH Terms: Animals, Breast Neoplasms, Cell Proliferation, Disease-Free Survival, Drug Resistance, Neoplasm, Estradiol, Estrogen Receptor alpha, Estrogens, Female, Fulvestrant, Gene Expression Regulation, Neoplastic, Humans, MCF-7 Cells, Membrane Glycoproteins, Mice, Receptor, ErbB-3, Xenograft Model Antitumor Assays
Added April 15, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Kinome-wide functional screen identifies role of PLK1 in hormone-independent, ER-positive breast cancer.
Bhola NE, Jansen VM, Bafna S, Giltnane JM, Balko JM, Estrada MV, Meszoely I, Mayer I, Abramson V, Ye F, Sanders M, Dugger TC, Allen EV, Arteaga CL
(2015) Cancer Res 75: 405-14
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Cell Cycle Proteins, Drug Synergism, Estradiol, Estrogen Receptor alpha, Female, Fulvestrant, Humans, MCF-7 Cells, Mice, Mice, Nude, Neoplasms, Hormone-Dependent, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins, Pteridines, RNA, Small Interfering, Random Allocation, Transcription Factors, Transcription, Genetic, Xenograft Model Antitumor Assays, bcl-X Protein
Added January 20, 2015
0 Communities
2 Members
0 Resources
23 MeSH Terms
ErbB3 downregulation enhances luminal breast tumor response to antiestrogens.
Morrison MM, Hutchinson K, Williams MM, Stanford JC, Balko JM, Young C, Kuba MG, Sánchez V, Williams AJ, Hicks DJ, Arteaga CL, Prat A, Perou CM, Earp HS, Massarweh S, Cook RS
(2013) J Clin Invest 123: 4329-43
MeSH Terms: Animals, Antibodies, Monoclonal, Antineoplastic Agents, Hormonal, Breast Neoplasms, Cell Proliferation, Cell Survival, Down-Regulation, Drug Resistance, Neoplasm, Drug Synergism, ErbB Receptors, Estradiol, Estrogen Receptor Modulators, Female, Fulvestrant, Gene Dosage, Gene Expression, Gene Expression Regulation, Neoplastic, Humans, MCF-7 Cells, Mice, Mice, Inbred BALB C, Mice, Nude, Oligonucleotide Array Sequence Analysis, Receptor, ErbB-2, Receptor, ErbB-3, Signal Transduction, Survival Analysis, Transcriptome, Xenograft Model Antitumor Assays
Added March 7, 2014
1 Communities
3 Members
0 Resources
29 MeSH Terms
A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer.
Fox EM, Miller TW, Balko JM, Kuba MG, Sánchez V, Smith RA, Liu S, González-Angulo AM, Mills GB, Ye F, Shyr Y, Manning HC, Buck E, Arteaga CL
(2011) Cancer Res 71: 6773-84
MeSH Terms: Adenocarcinoma, Animals, Antineoplastic Agents, Hormonal, Breast Neoplasms, Cell Line, Tumor, Disease-Free Survival, Estradiol, Estrogen Receptor Modulators, Estrogens, Female, Fulvestrant, Gene Expression Regulation, Neoplastic, Humans, Imidazoles, Insulin, Insulin-Like Growth Factor I, Mice, Mice, Nude, Neoplasm Proteins, Neoplasms, Hormone-Dependent, Protein-Tyrosine Kinases, Pyrazines, RNA Interference, Random Allocation, Receptor, IGF Type 1, Receptor, Insulin, Receptors, Estrogen, Signal Transduction, Tamoxifen, Xenograft Model Antitumor Assays
Added February 13, 2014
0 Communities
4 Members
0 Resources
30 MeSH Terms
Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer.
Rhodes LV, Short SP, Neel NF, Salvo VA, Zhu Y, Elliott S, Wei Y, Yu D, Sun M, Muir SE, Fonseca JP, Bratton MR, Segar C, Tilghman SL, Sobolik-Delmaire T, Horton LW, Zaja-Milatovic S, Collins-Burow BM, Wadsworth S, Beckman BS, Wood CE, Fuqua SA, Nephew KP, Dent P, Worthylake RA, Curiel TJ, Hung MC, Richmond A, Burow ME
(2011) Cancer Res 71: 603-13
MeSH Terms: Animals, Antineoplastic Agents, Hormonal, Breast Neoplasms, Cell Line, Tumor, Drug Resistance, Neoplasm, Estradiol, Estrogen Antagonists, Female, Fulvestrant, Humans, MAP Kinase Signaling System, Mice, Mice, SCID, Neoplasm Metastasis, Neoplasms, Hormone-Dependent, Receptors, CXCR4, Receptors, Estrogen
Added June 14, 2013
2 Communities
4 Members
0 Resources
17 MeSH Terms