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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 12

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A Derived Allosteric Switch Underlies the Evolution of Conditional Cooperativity between HOXA11 and FOXO1.
Nnamani MC, Ganguly S, Erkenbrack EM, Lynch VJ, Mizoue LS, Tong Y, Darling HL, Fuxreiter M, Meiler J, Wagner GP
(2016) Cell Rep 15: 2097-2108
MeSH Terms: Allosteric Regulation, Amino Acid Sequence, Amino Acid Substitution, Animals, Biological Evolution, CREB-Binding Protein, DNA-Activated Protein Kinase, Forkhead Box Protein O1, HeLa Cells, Homeodomain Proteins, Humans, Intrinsically Disordered Proteins, Mice, Models, Biological, Models, Molecular, Phosphorylation, Protein Binding, Protein Domains, Protein Structure, Secondary, Transcriptional Activation
Added April 8, 2017
1 Communities
1 Members
0 Resources
20 MeSH Terms
Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.
Scarlett JM, Rojas JM, Matsen ME, Kaiyala KJ, Stefanovski D, Bergman RN, Nguyen HT, Dorfman MD, Lantier L, Wasserman DH, Mirzadeh Z, Unterman TG, Morton GJ, Schwartz MW
(2016) Nat Med 22: 800-6
MeSH Terms: Adipose Tissue, Animals, Blood Glucose, Blotting, Western, Body Composition, Brain, Carbon Radioisotopes, Deoxyglucose, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Diet, High-Fat, Disease Models, Animal, Ependymoglial Cells, Fibroblast Growth Factor 1, Forkhead Box Protein O1, Glucose Tolerance Test, Heart, Heat-Shock Proteins, Hyperglycemia, Hypothalamus, Injections, Intraventricular, Liver, Male, Mice, Mice, Knockout, Mice, Obese, Molecular Chaperones, Muscle, Skeletal, Myocardium, Neoplasm Proteins, Proto-Oncogene Proteins c-fos, Rats, Rats, Zucker, Real-Time Polymerase Chain Reaction, Receptor, Insulin, Remission Induction
Added May 16, 2019
0 Communities
1 Members
0 Resources
36 MeSH Terms
Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers.
Chera S, Baronnier D, Ghila L, Cigliola V, Jensen JN, Gu G, Furuyama K, Thorel F, Gribble FM, Reimann F, Herrera PL
(2014) Nature 514: 503-7
MeSH Terms: Aging, Animals, Cell Dedifferentiation, Cell Proliferation, Cell Transdifferentiation, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Forkhead Box Protein O1, Forkhead Transcription Factors, Glucagon-Secreting Cells, Humans, Insulin, Insulin Secretion, Insulin-Secreting Cells, Mice, Regeneration, Sexual Maturation, Somatostatin, Somatostatin-Secreting Cells
Added October 15, 2015
1 Communities
1 Members
0 Resources
19 MeSH Terms
Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors.
Chakrabarty A, Bhola NE, Sutton C, Ghosh R, Kuba MG, Dave B, Chang JC, Arteaga CL
(2013) Cancer Res 73: 1190-200
MeSH Terms: Animals, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Drug Resistance, Neoplasm, Female, Forkhead Box Protein O1, Forkhead Box Protein O3, Forkhead Transcription Factors, Humans, Inhibitor of Apoptosis Proteins, Mice, Neoplastic Stem Cells, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Receptor, ErbB-2, Survivin, Trastuzumab
Added September 3, 2013
0 Communities
2 Members
0 Resources
17 MeSH Terms
Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.
Lee K, Nam KT, Cho SH, Gudapati P, Hwang Y, Park DS, Potter R, Chen J, Volanakis E, Boothby M
(2012) J Exp Med 209: 713-28
MeSH Terms: Active Transport, Cell Nucleus, Animals, Carrier Proteins, Cell Differentiation, Cell Lineage, Forkhead Box Protein O1, Forkhead Transcription Factors, Mice, Mice, Inbred C57BL, NF-kappa B, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins c-akt, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Rapamycin-Insensitive Companion of mTOR Protein, Receptors, Notch, TOR Serine-Threonine Kinases, Thymocytes
Added December 10, 2013
2 Communities
3 Members
0 Resources
18 MeSH Terms
The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress.
Yan L, Guo S, Brault M, Harmon J, Robertson RP, Hamid R, Stein R, Yang E
(2012) Biochem J 444: 239-47
MeSH Terms: Amino Acid Sequence, Animals, Cells, Cultured, Forkhead Box Protein O1, Forkhead Transcription Factors, HEK293 Cells, Humans, Insulin-Secreting Cells, Islets of Langerhans, Isoenzymes, Mice, Mice, Transgenic, Molecular Sequence Data, Oxidative Stress, Phosphorylation, Protein Phosphatase 2, Rats, Up-Regulation
Added March 7, 2014
0 Communities
2 Members
0 Resources
18 MeSH Terms
Generation of functional insulin-producing cells in the gut by Foxo1 ablation.
Talchai C, Xuan S, Kitamura T, DePinho RA, Accili D
(2012) Nat Genet 44: 406-12, S1
MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, C-Peptide, Cell Differentiation, Diabetes Mellitus, Experimental, Enteroendocrine Cells, Forkhead Box Protein O1, Forkhead Transcription Factors, Gastrointestinal Tract, Glucose, Hyperglycemia, Insulin, Insulin Secretion, Insulin-Secreting Cells, Mice, Mice, Transgenic, Nerve Tissue Proteins, Neuroendocrine Cells, Stem Cells, Streptozocin, Sulfonylurea Compounds, Wnt Signaling Pathway
Added April 13, 2012
0 Communities
0 Members
1 Resources
22 MeSH Terms
Will PI3K pathway inhibitors be effective as single agents in patients with cancer?
Garrett JT, Chakrabarty A, Arteaga CL
(2011) Oncotarget 2: 1314-21
MeSH Terms: Animals, Antineoplastic Agents, Forkhead Box Protein O1, Forkhead Transcription Factors, Humans, Mice, Neoplasms, Phosphatidylinositol 3-Kinase, Phosphoinositide-3 Kinase Inhibitors, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Receptor Protein-Tyrosine Kinases, Signal Transduction, TOR Serine-Threonine Kinases
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Suppression of hepatic glucose production by human neutrophil alpha-defensins through a signaling pathway distinct from insulin.
Liu HY, Collins QF, Moukdar F, Zhuo D, Han J, Hong T, Collins S, Cao W
(2008) J Biol Chem 283: 12056-63
MeSH Terms: Animals, Blood Glucose, Cell Line, Tumor, Cell Separation, Forkhead Box Protein O1, Forkhead Transcription Factors, Gluconeogenesis, Glucose, Hepatocytes, Humans, Insulin, Liver, Mice, Phosphorylation, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins pp60(c-src), Rats, Rats, Zucker, Signal Transduction, Transcription, Genetic, alpha-Defensins
Added July 23, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
The three insulin response sequences in the glucose-6-phosphatase catalytic subunit gene promoter are functionally distinct.
Vander Kooi BT, Streeper RS, Svitek CA, Oeser JK, Powell DR, O'Brien RM
(2003) J Biol Chem 278: 11782-93
MeSH Terms: Animals, Base Sequence, Carcinoma, Hepatocellular, Catalytic Domain, Chloramphenicol O-Acetyltransferase, DNA-Binding Proteins, Forkhead Box Protein O1, Forkhead Transcription Factors, Gene Expression Regulation, Enzymologic, Glucose-6-Phosphatase, Humans, Hypoglycemic Agents, Insulin, Insulin-Like Growth Factor Binding Protein 1, Mice, Nerve Tissue Proteins, Promoter Regions, Genetic, Rats, Recombinant Fusion Proteins, Transcription Factors, Transcriptional Activation, Tumor Cells, Cultured
Added July 10, 2013
0 Communities
1 Members
0 Resources
22 MeSH Terms