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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 36

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Matrix stiffness regulates vascular integrity through focal adhesion kinase activity.
Wang W, Lollis EM, Bordeleau F, Reinhart-King CA
(2019) FASEB J 33: 1199-1208
MeSH Terms: Adherens Junctions, Animals, Antigens, CD, Cadherins, Capillary Permeability, Chick Embryo, Endothelium, Vascular, Enzyme Activation, Extracellular Matrix, Female, Focal Adhesion Protein-Tyrosine Kinases, Human Umbilical Vein Endothelial Cells, Humans, Mice, Mice, Transgenic, Phosphorylation, Protein Transport, Tyrosine, src-Family Kinases
Added April 10, 2019
0 Communities
1 Members
0 Resources
19 MeSH Terms
miR-27 regulates chondrogenesis by suppressing focal adhesion kinase during pharyngeal arch development.
Kara N, Wei C, Commanday AC, Patton JG
(2017) Dev Biol 429: 321-334
MeSH Terms: Animal Fins, Animals, Branchial Region, Cartilage, Cell Differentiation, Cell Proliferation, Cell Survival, Chondrogenesis, Embryo, Nonmammalian, Focal Adhesion Protein-Tyrosine Kinases, Gene Expression Regulation, Developmental, Gene Knockdown Techniques, MicroRNAs, Morphogenesis, Neural Crest, Zebrafish
Added August 4, 2017
0 Communities
1 Members
0 Resources
16 MeSH Terms
SFK/FAK Signaling Attenuates Osimertinib Efficacy in Both Drug-Sensitive and Drug-Resistant Models of EGFR-Mutant Lung Cancer.
Ichihara E, Westover D, Meador CB, Yan Y, Bauer JA, Lu P, Ye F, Kulick A, de Stanchina E, McEwen R, Ladanyi M, Cross D, Pao W, Lovly CM
(2017) Cancer Res 77: 2990-3000
MeSH Terms: Acrylamides, Aniline Compounds, Animals, Antineoplastic Agents, Drug Resistance, Neoplasm, ErbB Receptors, Female, Focal Adhesion Protein-Tyrosine Kinases, Humans, Lung Neoplasms, Mice, Mice, Nude, Mutation, Piperazines, Signal Transduction, Transfection, src-Family Kinases
Added September 10, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Novel Small Molecule JP-153 Targets the Src-FAK-Paxillin Signaling Complex to Inhibit VEGF-Induced Retinal Angiogenesis.
Toutounchian JJ, Pagadala J, Miller DD, Baudry J, Park F, Chaum E, Morales-Tirado , Yates CR
(2017) Mol Pharmacol 91: 1-13
MeSH Terms: Animals, Benzoxazines, Cell Movement, Cell Proliferation, Disease Models, Animal, Endothelial Cells, Focal Adhesion Protein-Tyrosine Kinases, Humans, Mice, Inbred C57BL, Models, Biological, Oxygen, Paxillin, Retinal Neovascularization, Signal Transduction, Small Molecule Libraries, Vascular Endothelial Growth Factor A, src-Family Kinases
Added June 11, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Focal adhesions control cleavage furrow shape and spindle tilt during mitosis.
Taneja N, Fenix AM, Rathbun L, Millis BA, Tyska MJ, Hehnly H, Burnette DT
(2016) Sci Rep 6: 29846
MeSH Terms: Animals, Cell Differentiation, Cell Shape, Centrosome, Dogs, Focal Adhesion Protein-Tyrosine Kinases, Focal Adhesions, HeLa Cells, Humans, Madin Darby Canine Kidney Cells, Mitosis, Spindle Apparatus, Vinculin
Added April 7, 2017
1 Communities
2 Members
0 Resources
13 MeSH Terms
Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin.
Theodosiou M, Widmaier M, Böttcher RT, Rognoni E, Veelders M, Bharadwaj M, Lambacher A, Austen K, Müller DJ, Zent R, Fässler R
(2016) Elife 5: e10130
MeSH Terms: Animals, Cell Adhesion, Cell Line, Cell Movement, Cytoskeletal Proteins, Fibroblasts, Focal Adhesion Protein-Tyrosine Kinases, Integrin beta1, Manganese, Mice, Muscle Proteins, Paxillin, Protein Binding, Talin
Added February 4, 2016
1 Communities
1 Members
0 Resources
14 MeSH Terms
ErbB/integrin signaling interactions in regulation of myocardial cell-cell and cell-matrix interactions.
Pentassuglia L, Sawyer DB
(2013) Biochim Biophys Acta 1833: 909-16
MeSH Terms: Cardiomegaly, Cell Communication, Extracellular Matrix, Focal Adhesion Protein-Tyrosine Kinases, Gene Expression Regulation, Humans, Integrins, Isoenzymes, Myocardial Ischemia, Myocardium, Myocytes, Cardiac, Neuregulin-1, Oncogene Proteins v-erbB, Protein Binding, Signal Transduction
Added May 21, 2014
1 Communities
1 Members
0 Resources
15 MeSH Terms
Focal adhesion kinase is a component of antiviral RIG-I-like receptor signaling.
Bozym RA, Delorme-Axford E, Harris K, Morosky S, Ikizler M, Dermody TS, Sarkar SN, Coyne CB
(2012) Cell Host Microbe 11: 153-66
MeSH Terms: Adaptor Proteins, Signal Transducing, Cell Line, Focal Adhesion Protein-Tyrosine Kinases, Humans, Mitochondrial Membranes, Protein Interaction Mapping, RNA Viruses, Signal Transduction, Viral Plaque Assay
Added December 5, 2013
1 Communities
1 Members
0 Resources
9 MeSH Terms
Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease.
George B, Verma R, Soofi AA, Garg P, Zhang J, Park TJ, Giardino L, Ryzhova L, Johnstone DB, Wong H, Nihalani D, Salant DJ, Hanks SK, Curran T, Rastaldi MP, Holzman LB
(2012) J Clin Invest 122: 674-92
MeSH Terms: Adolescent, Adult, Aged, Animals, Cell Line, Crk-Associated Substrate Protein, Female, Focal Adhesion Protein-Tyrosine Kinases, Humans, Kidney Diseases, Kidney Glomerulus, Membrane Proteins, Mice, Mice, Knockout, Middle Aged, Phosphatidylinositol 3-Kinases, Podocytes, Proto-Oncogene Proteins c-crk, Pseudopodia, Rats, Rats, Sprague-Dawley, Recombinant Fusion Proteins, Signal Transduction, Young Adult
Added January 20, 2015
0 Communities
1 Members
0 Resources
24 MeSH Terms
Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness.
Janoštiak R, Tolde O, Brůhová Z, Novotný M, Hanks SK, Rösel D, Brábek J
(2011) Mol Biol Cell 22: 4256-67
MeSH Terms: Animals, Cell Adhesion Molecules, Cell Line, Transformed, Cell Line, Tumor, Cell Movement, Cell Transformation, Neoplastic, Crk-Associated Substrate Protein, Focal Adhesion Protein-Tyrosine Kinases, Focal Adhesions, Green Fluorescent Proteins, Humans, Mice, Mutation, Neoplasm Invasiveness, Phosphorylation, Protein Tyrosine Phosphatase, Non-Receptor Type 12, Signal Transduction, Tyrosine, src Homology Domains
Added January 20, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms