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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 7 of 7

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Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity.
Hargrove TY, Garvey EP, Hoekstra WJ, Yates CM, Wawrzak Z, Rachakonda G, Villalta F, Lepesheva GI
(2017) Antimicrob Agents Chemother 61:
MeSH Terms: Antifungal Agents, Aspergillus fumigatus, Candida albicans, Drugs, Investigational, Fluconazole, Ketoconazole, Microbial Sensitivity Tests, Pyridines, Sterol 14-Demethylase, Tetrazoles, Triazoles, Voriconazole
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Peripheral blood eosinophilia as a clue to the diagnosis of an occult Coccidioides infection.
Simons CM, Stratton CW, Kim AS
(2011) Hum Pathol 42: 449-53
MeSH Terms: Aged, Antifungal Agents, Antigens, Fungal, Coccidioides, Coccidioidomycosis, DNA, Fungal, Eosinophilia, Fluconazole, Humans, Lung Diseases, Fungal, Male, Radiography, Thoracic, Treatment Outcome
Added May 28, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Fluconazole prophylaxis for prevention of invasive fungal infections in targeted highest risk preterm infants limits drug exposure.
Weitkamp JH, Ozdas A, LaFleur B, Potts AL
(2008) J Perinatol 28: 405-11
MeSH Terms: Antifungal Agents, Fluconazole, Humans, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Infant, Very Low Birth Weight, Medical Order Entry Systems, Retrospective Studies, Risk Factors
Added February 27, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase.
Lepesheva GI, Zaitseva NG, Nes WD, Zhou W, Arase M, Liu J, Hill GC, Waterman MR
(2006) J Biol Chem 281: 3577-85
MeSH Terms: Animals, Antifungal Agents, Candida albicans, Cloning, Molecular, Cytochrome P-450 Enzyme System, Electrons, Escherichia coli, Fluconazole, Humans, Ligands, Models, Chemical, Models, Molecular, Molecular Sequence Data, Mutagenesis, Site-Directed, Mutation, Mycobacterium tuberculosis, Oxidoreductases, Phylogeny, Protein Conformation, Rats, Species Specificity, Sterol 14-Demethylase, Sterols, Substrate Specificity, Trypanosoma cruzi
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Fluconazole binding and sterol demethylation in three CYP51 isoforms indicate differences in active site topology.
Bellamine A, Lepesheva GI, Waterman MR
(2004) J Lipid Res 45: 2000-7
MeSH Terms: Amino Acid Sequence, Antifungal Agents, Binding Sites, Catalytic Domain, Cytochrome P-450 Enzyme System, DNA Primers, Fluconazole, Fungal Proteins, Humans, Inhibitory Concentration 50, Models, Chemical, Models, Molecular, Molecular Sequence Data, Mutagenesis, Site-Directed, Mutation, Mycobacterium tuberculosis, Oxidoreductases, Protein Binding, Protein Conformation, Protein Isoforms, Sequence Homology, Amino Acid, Species Specificity, Spectrophotometry, Sterol 14-Demethylase, Sterols, Time Factors
Added February 12, 2015
0 Communities
2 Members
0 Resources
26 MeSH Terms
Cryptococcosis in human immunodeficiency virus-negative patients in the era of effective azole therapy.
Pappas PG, Perfect JR, Cloud GA, Larsen RA, Pankey GA, Lancaster DJ, Henderson H, Kauffman CA, Haas DW, Saccente M, Hamill RJ, Holloway MS, Warren RM, Dismukes WE
(2001) Clin Infect Dis 33: 690-9
MeSH Terms: Adolescent, Adult, Aged, Aged, 80 and over, Antifungal Agents, Azoles, Child, Child, Preschool, Cryptococcosis, Cryptococcus neoformans, Female, Fluconazole, HIV Seronegativity, Humans, Infant, Male, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Prognosis, Risk Factors, Treatment Outcome, United States
Added March 13, 2015
0 Communities
1 Members
0 Resources
23 MeSH Terms
Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors.
Podust LM, Poulos TL, Waterman MR
(2001) Proc Natl Acad Sci U S A 98: 3068-73
MeSH Terms: Amino Acid Sequence, Antifungal Agents, Candida albicans, Crystallography, X-Ray, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Drug Resistance, Microbial, Enzyme Inhibitors, Fluconazole, Imidazoles, Molecular Sequence Data, Mycobacterium tuberculosis, Oxidoreductases, Peptide Mapping, Protein Structure, Tertiary, Sterol 14-Demethylase, Substrate Specificity
Added February 12, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms