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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 11

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RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT.
Kryshtal DO, Blackwell DJ, Egly CL, Smith AN, Batiste SM, Johnston JN, Laver DR, Knollmann BC
(2021) Circ Res 128: 321-331
MeSH Terms: Action Potentials, Animals, Anti-Arrhythmia Agents, Calcium Channel Blockers, Calcium Signaling, Calsequestrin, Disease Models, Animal, Female, Flecainide, HEK293 Cells, Heart Rate, Humans, Male, Mice, Knockout, Myocytes, Cardiac, Phosphorylation, Ryanodine Receptor Calcium Release Channel, Sarcoplasmic Reticulum, Sheep, Domestic, Tachycardia, Ventricular, Voltage-Gated Sodium Channel Blockers
Added December 21, 2020
1 Communities
0 Members
0 Resources
21 MeSH Terms
Efficacy of Flecainide in the Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia: A Randomized Clinical Trial.
Kannankeril PJ, Moore JP, Cerrone M, Priori SG, Kertesz NJ, Ro PS, Batra AS, Kaufman ES, Fairbrother DL, Saarel EV, Etheridge SP, Kanter RJ, Carboni MP, Dzurik MV, Fountain D, Chen H, Ely EW, Roden DM, Knollmann BC
(2017) JAMA Cardiol 2: 759-766
MeSH Terms: Adolescent, Adrenergic beta-Antagonists, Anti-Arrhythmia Agents, Cross-Over Studies, Death, Sudden, Cardiac, Defibrillators, Implantable, Drug Therapy, Combination, Exercise, Exercise Test, Female, Flecainide, Humans, Male, Maximum Tolerated Dose, Single-Blind Method, Tachycardia, Ventricular, Young Adult
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Channel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes.
Savio-Galimberti E, Knollmann BC
(2015) PLoS One 10: e0131179
MeSH Terms: Animals, Arrhythmias, Cardiac, Caffeine, Calcium, Calcium Signaling, Calsequestrin, Cell Membrane Permeability, Flecainide, Heart Ventricles, Humans, Inhibitory Concentration 50, Male, Mice, Inbred C57BL, Myocytes, Cardiac, Propafenone, Rabbits, Ryanodine Receptor Calcium Release Channel, Tetracaine
Added February 22, 2016
0 Communities
1 Members
0 Resources
18 MeSH Terms
Multiple modes of ryanodine receptor 2 inhibition by flecainide.
Mehra D, Imtiaz MS, van Helden DF, Knollmann BC, Laver DR
(2014) Mol Pharmacol 86: 696-706
MeSH Terms: Animals, Calcium, Calcium Channel Blockers, Flecainide, Hydrogen-Ion Concentration, Magnesium, Ryanodine Receptor Calcium Release Channel, Sheep
Added February 12, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms
Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia.
Steele DS, Hwang HS, Knollmann BC
(2013) Cardiovasc Res 98: 326-7
MeSH Terms: Animals, Calcium Signaling, Flecainide, Male, Sarcolemma, Voltage-Gated Sodium Channel Blockers
Added February 12, 2015
0 Communities
1 Members
0 Resources
6 MeSH Terms
Efficacy and potency of class I antiarrhythmic drugs for suppression of Ca2+ waves in permeabilized myocytes lacking calsequestrin.
Galimberti ES, Knollmann BC
(2011) J Mol Cell Cardiol 51: 760-8
MeSH Terms: Animals, Anti-Arrhythmia Agents, Calcium, Calcium Signaling, Calsequestrin, Cell Membrane Permeability, Cells, Cultured, Disease, Dose-Response Relationship, Drug, Flecainide, Humans, Inhibitory Concentration 50, Mice, Mice, Knockout, Microscopy, Confocal, Molecular Imaging, Myocytes, Cardiac, Propafenone, Saponins, Stereoisomerism, Tachycardia, Ventricular
Added July 21, 2014
1 Communities
0 Members
0 Resources
21 MeSH Terms
Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass.
Hilliard FA, Steele DS, Laver D, Yang Z, Le Marchand SJ, Chopra N, Piston DW, Huke S, Knollmann BC
(2010) J Mol Cell Cardiol 48: 293-301
MeSH Terms: Animals, Arrhythmias, Cardiac, Calcium, Calcium Channel Blockers, Calcium Signaling, Calcium-Binding Proteins, Cell Membrane Permeability, Flecainide, Humans, Mice, Myocytes, Cardiac, Rats, Ryanodine Receptor Calcium Release Channel, Sarcoplasmic Reticulum, Tetracaine
Added December 6, 2012
0 Communities
2 Members
0 Resources
15 MeSH Terms
The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel.
McBride BF, Yang T, Liu K, Urban TJ, Giacomini KM, Kim RB, Roden DM
(2009) J Cardiovasc Pharmacol 54: 63-71
MeSH Terms: Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Cation Transport Proteins, Electrophysiology, Ether-A-Go-Go Potassium Channels, Flecainide, Gene Expression, Heart, Humans, Immunohistochemistry, In Situ Hybridization, Inhibitory Concentration 50, Myocytes, Cardiac, Organic Cation Transport Proteins, Patch-Clamp Techniques, Potassium Channels, Quinidine, Sulfonamides, Symporters
Added June 26, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans.
Watanabe H, Chopra N, Laver D, Hwang HS, Davies SS, Roach DE, Duff HJ, Roden DM, Wilde AA, Knollmann BC
(2009) Nat Med 15: 380-3
MeSH Terms: Animals, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Calcium, Child, Flecainide, Heart Rate, Humans, Male, Mice, Polymorphism, Genetic, Ryanodine Receptor Calcium Release Channel, Syndrome, Tachycardia, Ventricular
Added June 1, 2013
1 Communities
2 Members
0 Resources
14 MeSH Terms
Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels.
Fukuda K, Davies SS, Nakajima T, Ong BH, Kupershmidt S, Fessel J, Amarnath V, Anderson ME, Boyden PA, Viswanathan PC, Roberts LJ, Balser JR
(2005) Circ Res 97: 1262-9
MeSH Terms: Aldehydes, Arrhythmias, Cardiac, Cell Line, Flecainide, Humans, Isoprostanes, Lipid Peroxidation, Myocardial Infarction, Myocardium, Oxidative Stress, Sodium Channels, tert-Butylhydroperoxide
Added December 10, 2013
1 Communities
3 Members
0 Resources
12 MeSH Terms