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Results: 1 to 3 of 3

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Bioflavonoids as poisons of human topoisomerase II alpha and II beta.
Bandele OJ, Osheroff N
(2007) Biochemistry 46: 6097-108
MeSH Terms: Alanine, Amino Acid Substitution, Antigens, Neoplasm, Antineoplastic Agents, Phytogenic, Cell Line, Tumor, DNA Damage, DNA Topoisomerases, Type II, DNA-Binding Proteins, Drug Resistance, Neoplasm, Flavones, Flavonoids, Flavonols, Genistein, Glycine, Humans, Isoenzymes, Isoflavones, Structure-Activity Relationship, Topoisomerase II Inhibitors
Added March 5, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Three acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK.
Xu YM, Smith JA, Lannigan DA, Hecht SM
(2006) Bioorg Med Chem 14: 3974-7
MeSH Terms: Acetylation, Apocynaceae, Enzyme Inhibitors, Flavonols, Glycosides, Molecular Structure, Plant Extracts, Ribosomal Protein S6 Kinases, 90-kDa, Species Specificity, Stereoisomerism
Added January 20, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs.
Vaclavikova R, Soucek P, Svobodova L, Anzenbacher P, Simek P, Guengerich FP, Gut I
(2004) Drug Metab Dispos 32: 666-74
MeSH Terms: Adolescent, Adult, Animals, Antineoplastic Agents, Phytogenic, Cytochrome P-450 Enzyme System, Docetaxel, Enzyme Inhibitors, Flavonoids, Flavonols, Humans, In Vitro Techniques, Isoenzymes, Kinetics, Male, Microsomes, Liver, Paclitaxel, Rats, Rats, Wistar, Species Specificity, Swine, Swine, Miniature, Taxoids, Troleandomycin
Added May 26, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms