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Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.
Gilchuk P, Murin CD, Milligan JC, Cross RW, Mire CE, Ilinykh PA, Huang K, Kuzmina N, Altman PX, Hui S, Gunn BM, Bryan AL, Davidson E, Doranz BJ, Turner HL, Alkutkar T, Flinko R, Orlandi C, Carnahan R, Nargi R, Bombardi RG, Vodzak ME, Li S, Okoli A, Ibeawuchi M, Ohiaeri B, Lewis GK, Alter G, Bukreyev A, Saphire EO, Geisbert TW, Ward AB, Crowe JE
(2020) Immunity 52: 388-403.e12
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Cell Line, Disease Models, Animal, Drug Therapy, Combination, Ebolavirus, Epitopes, Female, Glycoproteins, Hemorrhagic Fever, Ebola, Humans, Immunoglobulin Fab Fragments, Macaca mulatta, Male, Mice, Mice, Inbred BALB C, Molecular Mimicry, Protein Conformation
Added March 31, 2020
0 Communities
1 Members
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20 MeSH Terms
Epiglottitis.
Chapurin N, Gelbard A
(2019) N Engl J Med 381: e15
MeSH Terms: Deglutition Disorders, Epiglottitis, Fever, Humans, Male, Middle Aged, Neck, Radiography, Streptococcal Infections, Streptococcus pyogenes, Tracheostomy
Added July 30, 2020
0 Communities
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MeSH Terms
VU0810464, a non-urea G protein-gated inwardly rectifying K (K 3/GIRK) channel activator, exhibits enhanced selectivity for neuronal K 3 channels and reduces stress-induced hyperthermia in mice.
Vo BN, Abney KK, Anderson A, Marron Fernandez de Velasco E, Benneyworth MA, Daniels JS, Morrison RD, Hopkins CR, Weaver CD, Wickman K
(2019) Br J Pharmacol 176: 2238-2249
MeSH Terms: Animals, Anxiety, Behavior, Animal, Brain, Cells, Cultured, Female, Fever, G Protein-Coupled Inwardly-Rectifying Potassium Channels, Male, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Sinoatrial Node, Stress, Psychological
Added April 10, 2019
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14 MeSH Terms
Early Human B Cell Response to Ebola Virus in Four U.S. Survivors of Infection.
Williamson LE, Flyak AI, Kose N, Bombardi R, Branchizio A, Reddy S, Davidson E, Doranz BJ, Fusco ML, Saphire EO, Halfmann PJ, Kawaoka Y, Piper AE, Glass PJ, Crowe JE
(2019) J Virol 93:
MeSH Terms: Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, B-Lymphocytes, Ebolavirus, Female, Hemorrhagic Fever, Ebola, Humans, Immunologic Memory, Male, Survivors, United States, Viral Envelope Proteins
Added March 31, 2019
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13 MeSH Terms
Antibody-Mediated Protective Mechanisms Induced by a Trivalent Parainfluenza Virus-Vectored Ebolavirus Vaccine.
Kimble JB, Malherbe DC, Meyer M, Gunn BM, Karim MM, Ilinykh PA, Iampietro M, Mohamed KS, Negi S, Gilchuk P, Huang K, Wolf YI, Braun W, Crowe JE, Alter G, Bukreyev A
(2019) J Virol 93:
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Cell Line, Drug Combinations, Ebola Vaccines, Ebolavirus, Epitopes, Female, Ferrets, Genetic Vectors, Glycoproteins, Guinea Pigs, Hemorrhagic Fever, Ebola, Parainfluenza Virus 3, Human, Viral Envelope Proteins, Viral Vaccines
Added March 31, 2019
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18 MeSH Terms
A protective human monoclonal antibody targeting the West Nile virus E protein preferentially recognizes mature virions.
Goo L, Debbink K, Kose N, Sapparapu G, Doyle MP, Wessel AW, Richner JM, Burgomaster KE, Larman BC, Dowd KA, Diamond MS, Crowe JE, Pierson TC
(2019) Nat Microbiol 4: 71-77
MeSH Terms: Aedes, Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Cell Line, Chlorocebus aethiops, HEK293 Cells, Humans, Male, Mice, Mice, Inbred C57BL, Protein Domains, Vero Cells, Viral Envelope Proteins, West Nile Fever, West Nile Virus Vaccines, West Nile virus
Added March 31, 2019
0 Communities
1 Members
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18 MeSH Terms
In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model.
Patel A, Park DH, Davis CW, Smith TRF, Leung A, Tierney K, Bryan A, Davidson E, Yu X, Racine T, Reed C, Gorman ME, Wise MC, Elliott STC, Esquivel R, Yan J, Chen J, Muthumani K, Doranz BJ, Saphire EO, Crowe JE, Broderick KE, Kobinger GP, He S, Qiu X, Kobasa D, Humeau L, Sardesai NY, Ahmed R, Weiner DB
(2018) Cell Rep 25: 1982-1993.e4
MeSH Terms: Animals, Antibodies, Monoclonal, DNA, Disease Models, Animal, Ebolavirus, Epitope Mapping, Epitopes, Female, Glycoproteins, HEK293 Cells, Hemorrhagic Fever, Ebola, Humans, Mice, Inbred BALB C, Muscles, Mutagenesis, Recombinant Proteins
Added March 31, 2019
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1 Members
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16 MeSH Terms
Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein.
Gilchuk P, Kuzmina N, Ilinykh PA, Huang K, Gunn BM, Bryan A, Davidson E, Doranz BJ, Turner HL, Fusco ML, Bramble MS, Hoff NA, Binshtein E, Kose N, Flyak AI, Flinko R, Orlandi C, Carnahan R, Parrish EH, Sevy AM, Bombardi RG, Singh PK, Mukadi P, Muyembe-Tamfum JJ, Ohi MD, Saphire EO, Lewis GK, Alter G, Ward AB, Rimoin AW, Bukreyev A, Crowe JE
(2018) Immunity 49: 363-374.e10
MeSH Terms: 3T3 Cells, Adult, Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, CHO Cells, Cell Line, Chlorocebus aethiops, Cricetulus, Disease Models, Animal, Drosophila, Ebolavirus, Female, Ferrets, Glycoproteins, Guinea Pigs, Hemorrhagic Fever, Ebola, Humans, Immunoglobulin G, Jurkat Cells, Male, Mice, Mice, Inbred BALB C, Mice, Knockout, THP-1 Cells, Vero Cells
Added March 3, 2020
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MeSH Terms
Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques.
Broeckel R, Fox JM, Haese N, Kreklywich CN, Sukulpovi-Petty S, Legasse A, Smith PP, Denton M, Corvey C, Krishnan S, Colgin LMA, Ducore RM, Lewis AD, Axthelm MK, Mandron M, Cortez P, Rothblatt J, Rao E, Focken I, Carter K, Sapparapau G, Crowe JE, Diamond MS, Streblow DN
(2017) PLoS Negl Trop Dis 11: e0005637
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Viral, B-Lymphocytes, Chikungunya Fever, Chikungunya virus, Disease Models, Animal, Drug Evaluation, Preclinical, Immunologic Factors, Macaca mulatta, T-Lymphocytes, Treatment Outcome
Added March 14, 2018
0 Communities
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12 MeSH Terms
Cacna1g is a genetic modifier of epilepsy in a mouse model of Dravet syndrome.
Calhoun JD, Hawkins NA, Zachwieja NJ, Kearney JA
(2017) Epilepsia 58: e111-e115
MeSH Terms: Animals, Animals, Newborn, Calcium Channels, T-Type, Disease Models, Animal, Electroencephalography, Epilepsies, Myoclonic, Fever, Humans, Mice, Mice, Inbred C57BL, Mutation, RNA, Messenger, Video Recording
Added October 2, 2018
1 Communities
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MeSH Terms