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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 27

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Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor.
Puy C, Tucker EI, Matafonov A, Cheng Q, Zientek KD, Gailani D, Gruber A, McCarty OJ
(2015) Blood 125: 1488-96
MeSH Terms: Blood Coagulation, Blood Platelets, Blotting, Western, Cells, Cultured, Factor IX, Factor XIa, Factor Xa, Fibrin, Flow Cytometry, Human Umbilical Vein Endothelial Cells, Humans, Lipoproteins, Mutation, Recombinant Proteins
Added January 20, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
Factor XI as a target for antithrombotic therapy.
Bane CE, Gailani D
(2014) Drug Discov Today 19: 1454-8
MeSH Terms: Animals, Anticoagulants, Blood Coagulation, Drug Design, Factor XI, Factor XIa, Fibrinolytic Agents, Hemorrhage, Humans, Thromboembolism
Added January 20, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
The mechanism underlying activation of factor IX by factor XIa.
Gailani D, Geng Y, Verhamme I, Sun MF, Bajaj SP, Messer A, Emsley J
(2014) Thromb Res 133 Suppl 1: S48-51
MeSH Terms: Amino Acid Sequence, Animals, Factor IX, Factor XIa, Humans, Models, Molecular, Molecular Sequence Data, Protein Conformation, Protein Multimerization
Added May 19, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Evidence for factor IX-independent roles for factor XIa in blood coagulation.
Matafonov A, Cheng Q, Geng Y, Verhamme IM, Umunakwe O, Tucker EI, Sun MF, Serebrov V, Gruber A, Gailani D
(2013) J Thromb Haemost 11: 2118-27
MeSH Terms: Animals, Blood Coagulation, Electrophoresis, Polyacrylamide Gel, Factor IX, Factor XIa, Humans, Mice, Mice, Inbred C57BL, Proteolysis
Added May 19, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Factor XI anion-binding sites are required for productive interactions with polyphosphate.
Geng Y, Verhamme IM, Smith SA, Cheng Q, Sun M, Sheehan JP, Morrissey JH, Gailani D
(2013) J Thromb Haemost 11: 2020-8
MeSH Terms: Animals, Anions, Antithrombins, Binding Sites, Blood Coagulation, Cattle, Factor IX, Factor XI, Factor XIa, Heparin, Humans, Mice, Mice, Inbred C57BL, Polymers, Polyphosphates, Recombinant Proteins, Thrombin, Thrombosis
Added May 19, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates.
Puy C, Tucker EI, Wong ZC, Gailani D, Smith SA, Choi SH, Morrissey JH, Gruber A, McCarty OJ
(2013) J Thromb Haemost 11: 1341-52
MeSH Terms: Animals, Antibodies, Neutralizing, Blood Coagulation, Factor XI, Factor XI Deficiency, Factor XII, Factor XIIa, Factor XIa, Humans, Plant Proteins, Polyphosphates, Prothrombin, Thrombin, Thrombosis, Time Factors
Added May 19, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Analysis of the factor XI variant Arg184Gly suggests a structural basis for factor IX binding to factor XIa.
Geng Y, Verhamme IM, Sun MF, Bajaj SP, Emsley J, Gailani D
(2013) J Thromb Haemost 11: 1374-84
MeSH Terms: Arginine, Blood Coagulation, Blood Coagulation Tests, Enzyme Activation, Factor IX, Factor XI Deficiency, Factor XIa, Glycine, HEK293 Cells, Humans, Kinetics, Models, Molecular, Mutation, Protein Binding, Protein Conformation, Protein Interaction Domains and Motifs, Protein Interaction Mapping, Structure-Activity Relationship, Transfection
Added May 19, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
The dimeric structure of factor XI and zymogen activation.
Geng Y, Verhamme IM, Smith SB, Sun MF, Matafonov A, Cheng Q, Smith SA, Morrissey JH, Gailani D
(2013) Blood 121: 3962-9
MeSH Terms: Animals, Carotid Artery Thrombosis, Factor XI, Factor XI Deficiency, Factor XIIa, Factor XIa, HEK293 Cells, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Biological, Protein Binding, Protein Multimerization, Protein Structure, Quaternary
Added May 19, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Discovery of allosteric modulators of factor XIa by targeting hydrophobic domains adjacent to its heparin-binding site.
Karuturi R, Al-Horani RA, Mehta SC, Gailani D, Desai UR
(2013) J Med Chem 56: 2415-28
MeSH Terms: Allosteric Regulation, Biomimetic Materials, Catalytic Domain, Drug Discovery, Factor XIa, Glycosaminoglycans, Heparin, Humans, Hydrophobic and Hydrophilic Interactions, Protease Inhibitors, Quinazolinones, Sulfates
Added May 19, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Sulfated pentagalloylglucoside is a potent, allosteric, and selective inhibitor of factor XIa.
Al-Horani RA, Ponnusamy P, Mehta AY, Gailani D, Desai UR
(2013) J Med Chem 56: 867-78
MeSH Terms: Allosteric Regulation, Carbohydrate Sequence, Chromatography, Liquid, Enzyme Activation, Factor XIa, Glucosides, Hydrolysis, Kinetics, Magnetic Resonance Spectroscopy, Molecular Mimicry, Molecular Sequence Data, Serine Proteinase Inhibitors, Spectrometry, Mass, Electrospray Ionization, Sulfuric Acid Esters, Thrombelastography
Added May 19, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms