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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 91

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Excess of heme induces tissue factor-dependent activation of coagulation in mice.
Sparkenbaugh EM, Chantrathammachart P, Wang S, Jonas W, Kirchhofer D, Gailani D, Gruber A, Kasthuri R, Key NS, Mackman N, Pawlinski R
(2015) Haematologica 100: 308-14
MeSH Terms: Anemia, Hemolytic, Anemia, Sickle Cell, Animals, Antibodies, Blood Coagulation, Capillary Permeability, Cells, Cultured, Factor XI, Factor XIIa, Female, Gene Deletion, Gene Expression, Heme, Hemopexin, Humans, Injections, Intravenous, Leukocytes, Mononuclear, Macrophages, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, RNA, Small Interfering, Swine, Thromboplastin
Added January 20, 2015
0 Communities
1 Members
0 Resources
25 MeSH Terms
Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor.
Puy C, Tucker EI, Matafonov A, Cheng Q, Zientek KD, Gailani D, Gruber A, McCarty OJ
(2015) Blood 125: 1488-96
MeSH Terms: Blood Coagulation, Blood Platelets, Blotting, Western, Cells, Cultured, Factor IX, Factor XIa, Factor Xa, Fibrin, Flow Cytometry, Human Umbilical Vein Endothelial Cells, Humans, Lipoproteins, Mutation, Recombinant Proteins
Added January 20, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
Factor XI antisense oligonucleotide for prevention of venous thrombosis.
Büller HR, Bethune C, Bhanot S, Gailani D, Monia BP, Raskob GE, Segers A, Verhamme P, Weitz JI, FXI-ASO TKA Investigators
(2015) N Engl J Med 372: 232-40
MeSH Terms: Adult, Aged, Anticoagulants, Arthroplasty, Replacement, Knee, Blood Coagulation, Clinical Protocols, Enoxaparin, Factor XI, Female, Hemorrhage, Humans, Length of Stay, Male, Middle Aged, Oligonucleotides, Oligonucleotides, Antisense, Partial Thromboplastin Time, Postoperative Complications, Venous Thrombosis
Added January 20, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion.
Raghu H, Cruz C, Rewerts CL, Frederick MD, Thornton S, Mullins ES, Schoenecker JG, Degen JL, Flick MJ
(2015) Blood 125: 427-37
MeSH Terms: Animals, Arthritis, Experimental, Blotting, Western, Bone Diseases, Cell Differentiation, Cells, Cultured, Collagen, Factor XIII, Female, Inflammation, Male, Mice, Mice, Inbred DBA, Mice, Knockout, Osteoclasts, RANK Ligand, RNA, Messenger, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction
Added February 22, 2016
0 Communities
1 Members
0 Resources
19 MeSH Terms
Development of anti-factor XIII antibodies in a patient with hereditary factor XIII deficiency receiving therapy for chronic hepatitis C.
Sosa R, Gailani D, Neff AT
(2014) Haemophilia 20: e429-32
MeSH Terms: Adult, Antibodies, Antiviral Agents, Blood Coagulation Factor Inhibitors, Factor XIII, Factor XIII Deficiency, Female, Hepatitis C, Chronic, Humans, Immunosuppressive Agents, Treatment Outcome
Added January 20, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
Factor XI as a target for antithrombotic therapy.
Bane CE, Gailani D
(2014) Drug Discov Today 19: 1454-8
MeSH Terms: Animals, Anticoagulants, Blood Coagulation, Drug Design, Factor XI, Factor XIa, Fibrinolytic Agents, Hemorrhage, Humans, Thromboembolism
Added January 20, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
The mechanism underlying activation of factor IX by factor XIa.
Gailani D, Geng Y, Verhamme I, Sun MF, Bajaj SP, Messer A, Emsley J
(2014) Thromb Res 133 Suppl 1: S48-51
MeSH Terms: Amino Acid Sequence, Animals, Factor IX, Factor XIa, Humans, Models, Molecular, Molecular Sequence Data, Protein Conformation, Protein Multimerization
Added May 19, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Factor XII inhibition reduces thrombus formation in a primate thrombosis model.
Matafonov A, Leung PY, Gailani AE, Grach SL, Puy C, Cheng Q, Sun MF, McCarty OJ, Tucker EI, Kataoka H, Renné T, Morrissey JH, Gruber A, Gailani D
(2014) Blood 123: 1739-46
MeSH Terms: Animals, Antibodies, Monoclonal, Blood Coagulation, Disease Models, Animal, Factor XI, Factor XII, Factor XII Deficiency, Factor XIIa, Fibrin, Humans, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Papio, Recombinant Proteins, Thrombin, Thromboplastin, Thrombosis
Added May 19, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Evidence for factor IX-independent roles for factor XIa in blood coagulation.
Matafonov A, Cheng Q, Geng Y, Verhamme IM, Umunakwe O, Tucker EI, Sun MF, Serebrov V, Gruber A, Gailani D
(2013) J Thromb Haemost 11: 2118-27
MeSH Terms: Animals, Blood Coagulation, Electrophoresis, Polyacrylamide Gel, Factor IX, Factor XIa, Humans, Mice, Mice, Inbred C57BL, Proteolysis
Added May 19, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Factor XI anion-binding sites are required for productive interactions with polyphosphate.
Geng Y, Verhamme IM, Smith SA, Cheng Q, Sun M, Sheehan JP, Morrissey JH, Gailani D
(2013) J Thromb Haemost 11: 2020-8
MeSH Terms: Animals, Anions, Antithrombins, Binding Sites, Blood Coagulation, Cattle, Factor IX, Factor XI, Factor XIa, Heparin, Humans, Mice, Mice, Inbred C57BL, Polymers, Polyphosphates, Recombinant Proteins, Thrombin, Thrombosis
Added May 19, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms