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Results: 1 to 10 of 24

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Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates.
Puy C, Tucker EI, Wong ZC, Gailani D, Smith SA, Choi SH, Morrissey JH, Gruber A, McCarty OJ
(2013) J Thromb Haemost 11: 1341-52
MeSH Terms: Animals, Antibodies, Neutralizing, Blood Coagulation, Factor XI, Factor XI Deficiency, Factor XII, Factor XIIa, Factor XIa, Humans, Plant Proteins, Polyphosphates, Prothrombin, Thrombin, Thrombosis, Time Factors
Added May 19, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Analysis of the factor XI variant Arg184Gly suggests a structural basis for factor IX binding to factor XIa.
Geng Y, Verhamme IM, Sun MF, Bajaj SP, Emsley J, Gailani D
(2013) J Thromb Haemost 11: 1374-84
MeSH Terms: Arginine, Blood Coagulation, Blood Coagulation Tests, Enzyme Activation, Factor IX, Factor XI Deficiency, Factor XIa, Glycine, HEK293 Cells, Humans, Kinetics, Models, Molecular, Mutation, Protein Binding, Protein Conformation, Protein Interaction Domains and Motifs, Protein Interaction Mapping, Structure-Activity Relationship, Transfection
Added May 19, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
The dimeric structure of factor XI and zymogen activation.
Geng Y, Verhamme IM, Smith SB, Sun MF, Matafonov A, Cheng Q, Smith SA, Morrissey JH, Gailani D
(2013) Blood 121: 3962-9
MeSH Terms: Animals, Carotid Artery Thrombosis, Factor XI, Factor XI Deficiency, Factor XIIa, Factor XIa, HEK293 Cells, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Biological, Protein Binding, Protein Multimerization, Protein Structure, Quaternary
Added May 19, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Factor XI-deficient mice display reduced inflammation, coagulopathy, and bacterial growth during listeriosis.
Luo D, Szaba FM, Kummer LW, Johnson LL, Tucker EI, Gruber A, Gailani D, Smiley ST
(2012) Infect Immun 80: 91-9
MeSH Terms: Animals, Anti-Bacterial Agents, Antibodies, Disseminated Intravascular Coagulation, Drug Therapy, Combination, Factor XI Deficiency, Inflammation, Listeria monocytogenes, Listeriosis, Liver, Mice, Mice, Inbred C57BL, Mice, Knockout, Survival Analysis, Treatment Outcome
Added May 19, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Acquired factor XI deficiency in a child with membranoproliferative glomerulonephritis.
McManus MP, Frantz C, Gailani D
(2012) Pediatr Blood Cancer 59: 173-5
MeSH Terms: Autoantibodies, Blood Coagulation Factor Inhibitors, Child, Factor XI, Factor XI Deficiency, Glomerulonephritis, Membranoproliferative, Humans, Male
Added May 19, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Factor XI and XII as antithrombotic targets.
Müller F, Gailani D, Renné T
(2011) Curr Opin Hematol 18: 349-55
MeSH Terms: Animals, Anticoagulants, Blood Coagulation, Factor XI, Factor XI Deficiency, Factor XII, Factor XII Deficiency, Hemostasis, Humans, Thrombosis
Added May 19, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo.
Cheng Q, Tucker EI, Pine MS, Sisler I, Matafonov A, Sun MF, White-Adams TC, Smith SA, Hanson SR, McCarty OJ, Renné T, Gruber A, Gailani D
(2010) Blood 116: 3981-9
MeSH Terms: Animals, Antibodies, Monoclonal, Anticoagulants, Carotid Artery Thrombosis, Cats, Disease Models, Animal, Dogs, Factor XI, Factor XI Deficiency, Factor XII Deficiency, Factor XIIa, Humans, In Vitro Techniques, Male, Mice, Mice, Inbred BALB C, Mice, Knockout, Papio anubis, Partial Thromboplastin Time, Pulmonary Embolism, Rabbits, Species Specificity, Thrombosis
Added May 19, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
Structure and function of factor XI.
Emsley J, McEwan PA, Gailani D
(2010) Blood 115: 2569-77
MeSH Terms: Blood Coagulation, Blood Platelets, Catalytic Domain, Dimerization, Enzyme Activation, Evolution, Molecular, Factor IX, Factor XI, Factor XI Deficiency, Forecasting, Humans, Models, Molecular, Mutation, Platelet Membrane Glycoproteins, Prekallikrein, Protein Binding, Protein Conformation, Protein Interaction Mapping, Protein Structure, Tertiary, Structure-Activity Relationship
Added May 19, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Update on the physiology and pathology of factor IX activation by factor XIa.
Smith SB, Gailani D
(2008) Expert Rev Hematol 1: 87-98
MeSH Terms: Animals, Disease Models, Animal, Factor IX, Factor XI Deficiency, Factor XIa, Humans, Thrombosis
Added May 19, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms
Survival advantage of coagulation factor XI-deficient mice during peritoneal sepsis.
Tucker EI, Gailani D, Hurst S, Cheng Q, Hanson SR, Gruber A
(2008) J Infect Dis 198: 271-4
MeSH Terms: Animals, Blood Coagulation, Cecum, Factor XI, Factor XI Deficiency, Inflammation, Mice, Mice, Inbred C57BL, Mice, Knockout, Peritoneal Diseases, Peritonitis, Punctures, Reference Values, Sepsis, Survivors
Added May 19, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms