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Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor.
Puy C, Tucker EI, Matafonov A, Cheng Q, Zientek KD, Gailani D, Gruber A, McCarty OJ
(2015) Blood 125: 1488-96
MeSH Terms: Blood Coagulation, Blood Platelets, Blotting, Western, Cells, Cultured, Factor IX, Factor XIa, Factor Xa, Fibrin, Flow Cytometry, Human Umbilical Vein Endothelial Cells, Humans, Lipoproteins, Mutation, Recombinant Proteins
Added January 20, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
Females with FVIII and FIX deficiency have reduced joint range of motion.
Sidonio RF, Mili FD, Li T, Miller CH, Hooper WC, DeBaun MR, Soucie M, Hemophilia Treatment Centers Network
(2014) Am J Hematol 89: 831-6
MeSH Terms: Adolescent, Adult, Aged, Body Mass Index, Case-Control Studies, Child, Child, Preschool, Cross-Sectional Studies, Demography, Factor IX, Factor VIII, Female, Hemophilia A, Hemophilia B, Humans, Joints, Middle Aged, Range of Motion, Articular, Severity of Illness Index
Added October 7, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
The mechanism underlying activation of factor IX by factor XIa.
Gailani D, Geng Y, Verhamme I, Sun MF, Bajaj SP, Messer A, Emsley J
(2014) Thromb Res 133 Suppl 1: S48-51
MeSH Terms: Amino Acid Sequence, Animals, Factor IX, Factor XIa, Humans, Models, Molecular, Molecular Sequence Data, Protein Conformation, Protein Multimerization
Added May 19, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Evidence for factor IX-independent roles for factor XIa in blood coagulation.
Matafonov A, Cheng Q, Geng Y, Verhamme IM, Umunakwe O, Tucker EI, Sun MF, Serebrov V, Gruber A, Gailani D
(2013) J Thromb Haemost 11: 2118-27
MeSH Terms: Animals, Blood Coagulation, Electrophoresis, Polyacrylamide Gel, Factor IX, Factor XIa, Humans, Mice, Mice, Inbred C57BL, Proteolysis
Added May 19, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Factor XI anion-binding sites are required for productive interactions with polyphosphate.
Geng Y, Verhamme IM, Smith SA, Cheng Q, Sun M, Sheehan JP, Morrissey JH, Gailani D
(2013) J Thromb Haemost 11: 2020-8
MeSH Terms: Animals, Anions, Antithrombins, Binding Sites, Blood Coagulation, Cattle, Factor IX, Factor XI, Factor XIa, Heparin, Humans, Mice, Mice, Inbred C57BL, Polyelectrolytes, Polymers, Polyphosphates, Recombinant Proteins, Thrombin, Thrombosis
Added May 19, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Analysis of the factor XI variant Arg184Gly suggests a structural basis for factor IX binding to factor XIa.
Geng Y, Verhamme IM, Sun MF, Bajaj SP, Emsley J, Gailani D
(2013) J Thromb Haemost 11: 1374-84
MeSH Terms: Arginine, Blood Coagulation, Blood Coagulation Tests, Enzyme Activation, Factor IX, Factor XI Deficiency, Factor XIa, Glycine, HEK293 Cells, Humans, Kinetics, Models, Molecular, Mutation, Protein Binding, Protein Conformation, Protein Interaction Domains and Motifs, Protein Interaction Mapping, Structure-Activity Relationship, Transfection
Added May 19, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
A sequential mechanism for exosite-mediated factor IX activation by factor XIa.
Geng Y, Verhamme IM, Messer A, Sun MF, Smith SB, Bajaj SP, Gailani D
(2012) J Biol Chem 287: 38200-9
MeSH Terms: Arginine, Binding Sites, Binding, Competitive, Biocatalysis, Calcium, Catalytic Domain, Electrophoresis, Polyacrylamide Gel, Factor IX, Factor IXa, Factor XIa, HEK293 Cells, Humans, Kinetics, Mutation, Oligopeptides, Protein Multimerization, Proteolysis, Pyrrolidonecarboxylic Acid, Recombinant Proteins, Substrate Specificity
Added May 19, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Long-term phenotypic correction in factor IX knockout mice by using ΦC31 integrase-mediated gene therapy.
Keravala A, Chavez CL, Hu G, Woodard LE, Monahan PE, Calos MP
(2011) Gene Ther 18: 842-8
MeSH Terms: Animals, Bacteriophages, Disease Models, Animal, Factor IX, Gene Transfer Techniques, Genetic Therapy, Hemophilia B, Integrases, Mice, Mice, Knockout
Added December 8, 2017
0 Communities
1 Members
0 Resources
10 MeSH Terms
Structure and function of factor XI.
Emsley J, McEwan PA, Gailani D
(2010) Blood 115: 2569-77
MeSH Terms: Blood Coagulation, Blood Platelets, Catalytic Domain, Dimerization, Enzyme Activation, Evolution, Molecular, Factor IX, Factor XI, Factor XI Deficiency, Forecasting, Humans, Models, Molecular, Mutation, Platelet Membrane Glycoproteins, Prekallikrein, Protein Binding, Protein Conformation, Protein Interaction Mapping, Protein Structure, Tertiary, Structure-Activity Relationship
Added May 19, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Effect of nuclear localization and hydrodynamic delivery-induced cell division on phiC31 integrase activity.
Woodard LE, Hillman RT, Keravala A, Lee S, Calos MP
(2010) Gene Ther 17: 217-26
MeSH Terms: Animals, Attachment Sites, Microbiological, Bacteriophages, Cell Division, Cell Nucleus, Cell Proliferation, DNA Replication, Factor IX, Gene Expression, Gene Transfer Techniques, HeLa Cells, Humans, Integrases, Mice, Nuclear Localization Signals, Pressure, Simian virus 40, Transgenes
Added December 8, 2017
0 Communities
1 Members
0 Resources
18 MeSH Terms