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Results: 1 to 10 of 94

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Fibroblast-specific plasminogen activator inhibitor-1 depletion ameliorates renal interstitial fibrosis after unilateral ureteral obstruction.
Yao L, Wright MF, Farmer BC, Peterson LS, Khan AM, Zhong J, Gewin L, Hao CM, Yang HC, Fogo AB
(2019) Nephrol Dial Transplant 34: 2042-2050
MeSH Terms: Actins, Animals, Collagen Type I, Connective Tissue Growth Factor, Extracellular Matrix Proteins, Fibroblasts, Fibrosis, Kidney Diseases, Mice, Mice, Knockout, Nerve Tissue Proteins, Serpin E2, Transforming Growth Factor beta, Ureteral Obstruction
Added March 18, 2020
0 Communities
1 Members
0 Resources
14 MeSH Terms
Peroxidasin and eosinophil peroxidase, but not myeloperoxidase, contribute to renal fibrosis in the murine unilateral ureteral obstruction model.
Colon S, Luan H, Liu Y, Meyer C, Gewin L, Bhave G
(2019) Am J Physiol Renal Physiol 316: F360-F371
MeSH Terms: Animals, Cell Movement, Disease Models, Animal, Eosinophil Peroxidase, Eosinophils, Extracellular Matrix Proteins, Female, Fibrosis, Kidney, Male, Mice, Inbred C57BL, Mice, Knockout, Nephritis, Interstitial, Peroxidase, Peroxidases, Reactive Oxygen Species, Signal Transduction, Ureteral Obstruction
Added March 26, 2019
0 Communities
2 Members
0 Resources
18 MeSH Terms
Inhibitory Anti-Peroxidasin Antibodies in Pulmonary-Renal Syndromes.
McCall AS, Bhave G, Pedchenko V, Hess J, Free M, Little DJ, Baker TP, Pendergraft WF, Falk RJ, Olson SW, Hudson BG
(2018) J Am Soc Nephrol 29: 2619-2625
MeSH Terms: Adolescent, Adult, Aged, Aged, 80 and over, Anti-Glomerular Basement Membrane Disease, Antibodies, Antineutrophil Cytoplasmic, Antibody Specificity, Autoantibodies, Autoantigens, Child, Cohort Studies, Collagen Type IV, Extracellular Matrix Proteins, Female, Glomerulonephritis, Hemorrhage, Humans, Lung Diseases, Male, Middle Aged, Models, Immunological, Peroxidase, Peroxidases, Young Adult
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
In vivo Raman spectral analysis of impaired cervical remodeling in a mouse model of delayed parturition.
O'Brien CM, Herington JL, Brown N, Pence IJ, Paria BC, Slaughter JC, Reese J, Mahadevan-Jansen A
(2017) Sci Rep 7: 6835
MeSH Terms: Animals, Cervix Uteri, Cyclooxygenase 1, Extracellular Matrix Proteins, Female, Lipid Metabolism, Membrane Proteins, Mice, Nucleic Acids, Spectrum Analysis, Raman, Term Birth, Uterine Contraction
Added October 11, 2017
0 Communities
2 Members
0 Resources
12 MeSH Terms
Role of Hypohalous Acids in Basement Membrane Homeostasis.
Colon S, Page-McCaw P, Bhave G
(2017) Antioxid Redox Signal 27: 839-854
MeSH Terms: Animals, Basement Membrane, Bromates, Collagen Type IV, Extracellular Matrix Proteins, Homeostasis, Oxidative Stress, Peroxidase
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
The sulfilimine cross-link of collagen IV contributes to kidney tubular basement membrane stiffness.
Bhave G, Colon S, Ferrell N
(2017) Am J Physiol Renal Physiol 313: F596-F602
MeSH Terms: Animals, Basement Membrane, Biomechanical Phenomena, Collagen Type IV, Cross-Linking Reagents, Elastic Modulus, Extracellular Matrix Proteins, Genotype, Imines, Kidney, Mice, Inbred C57BL, Mice, Knockout, Peroxidase, Phenotype, Protein Conformation, Tensile Strength
Added December 7, 2017
1 Communities
1 Members
0 Resources
16 MeSH Terms
Proprotein Convertase Processing Enhances Peroxidasin Activity to Reinforce Collagen IV.
Colon S, Bhave G
(2016) J Biol Chem 291: 24009-24016
MeSH Terms: Basement Membrane, Collagen Type IV, Extracellular Matrix Proteins, HEK293 Cells, Humans, Peroxidase, Proprotein Convertases, Protein Domains
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit during uterine reprogramming.
Jones-Paris CR, Paria S, Berg T, Saus J, Bhave G, Paria BC, Hudson BG
(2017) Matrix Biol 57-58: 347-365
MeSH Terms: Animals, Basement Membrane, Collagen Type IV, Embryo Implantation, Extracellular Matrix Proteins, Female, Fluorescent Antibody Technique, Gene Expression Regulation, Injections, Laminin, Mice, Peptide Fragments, Peroxidase, Pregnancy, Protein-Serine-Threonine Kinases, RNA, Messenger, Sesame Oil, Uterus
Added October 30, 2016
1 Communities
2 Members
3 Resources
18 MeSH Terms
Epithelial PIK3R1 (p85) and TP53 Regulate Survivin Expression during Adaptation to Ileocecal Resection.
Cohran V, Managlia E, Bradford EM, Goretsky T, Li T, Katzman RB, Cheresh P, Brown JB, Hawkins J, Liu SXL, De Plaen IG, Weitkamp JH, Helmrath M, Zhang Z, Barrett TA
(2016) Am J Pathol 186: 1837-1846
MeSH Terms: Adaptation, Physiological, Animals, Blotting, Western, Class Ia Phosphatidylinositol 3-Kinase, Digestive System Surgical Procedures, Disease Models, Animal, Enterocolitis, Necrotizing, Extracellular Matrix Proteins, Gene Expression Regulation, Humans, Immunohistochemistry, Infant, Infant, Newborn, Inhibitor of Apoptosis Proteins, Mice, Mice, Inbred C57BL, Phosphatidylinositol 3-Kinases, Real-Time Polymerase Chain Reaction, Repressor Proteins, Short Bowel Syndrome, Survivin, Tumor Suppressor Protein p53
Added April 16, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Origin of Matrix-Producing Cells That Contribute to Aortic Fibrosis in Hypertension.
Wu J, Montaniel KR, Saleh MA, Xiao L, Chen W, Owens GK, Humphrey JD, Majesky MW, Paik DT, Hatzopoulos AK, Madhur MS, Harrison DG
(2016) Hypertension 67: 461-8
MeSH Terms: Animals, Aorta, Thoracic, Aortic Diseases, Cells, Cultured, Collagen, Disease Models, Animal, Extracellular Matrix Proteins, Fibroblasts, Fibrosis, Flow Cytometry, Hypertension, Immunohistochemistry, Male, Mice, Mice, Inbred C57BL, Muscle, Smooth, Vascular
Show Abstract · Added February 23, 2016
Various hypertensive stimuli lead to exuberant adventitial collagen deposition in large arteries, exacerbating blood pressure elevation and end-organ damage. Collagen production is generally attributed to resident fibroblasts; however, other cells, including resident and bone marrow-derived stem cell antigen positive (Sca-1(+)) cells and endothelial and vascular smooth muscle cells, can produce collagen and contribute to vascular stiffening. Using flow cytometry and immunofluorescence, we found that adventitial Sca-1(+) progenitor cells begin to produce collagen and acquire a fibroblast-like phenotype in hypertension. We also found that bone marrow-derived cells represent more than half of the matrix-producing cells in hypertension, and that one-third of these are Sca-1(+). Cell sorting and lineage-tracing studies showed that cells of endothelial origin contribute to no more than one fourth of adventitial collagen I(+) cells, whereas those of vascular smooth muscle lineage do not contribute. Our findings indicate that Sca-1(+) progenitor cells and bone marrow-derived infiltrating fibrocytes are major sources of arterial fibrosis in hypertension. Endothelial to mesenchymal transition likely also contributes, albeit to a lesser extent and pre-existing resident fibroblasts represent a minority of aortic collagen-producing cells in hypertension. This study shows that vascular stiffening represents a complex process involving recruitment and transformation of multiple cells types that ultimately elaborate adventitial extracellular matrix.
© 2015 American Heart Association, Inc.
2 Communities
2 Members
0 Resources
16 MeSH Terms