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Results: 1 to 8 of 8

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The yeast eukaryotic translation initiation factor 2B translation initiation complex interacts with the fatty acid synthesis enzyme YBR159W and endoplasmic reticulum membranes.
Browne CM, Samir P, Fites JS, Villarreal SA, Link AJ
(2013) Mol Cell Biol 33: 1041-56
MeSH Terms: 3-Hydroxyacyl CoA Dehydrogenases, Endoplasmic Reticulum, Eukaryotic Initiation Factor-2B, Fatty Acids, Protein Interaction Mapping, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Added December 5, 2013
1 Communities
1 Members
0 Resources
7 MeSH Terms
Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis.
Arrojo E Drigo R, Fonseca TL, Castillo M, Salathe M, Simovic G, Mohácsik P, Gereben B, Bianco AC
(2011) Mol Endocrinol 25: 2065-75
MeSH Terms: Animals, Cell Line, Cystic Fibrosis, Down-Regulation, Endoplasmic Reticulum Stress, Epithelial Cells, Eukaryotic Initiation Factor-2, Gene Expression, Humans, Iodide Peroxidase, Mice, Proteasome Endopeptidase Complex, Protein Stability, Proteolysis, Respiratory Mucosa, Signal Transduction, Thapsigargin, Thyroxine, Transcription Factor CHOP, Triiodothyronine, Tunicamycin
Added April 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation.
Liu Y, László C, Liu Y, Liu W, Chen X, Evans SC, Wu S
(2010) Neoplasia 12: 61-8
MeSH Terms: Animals, Apoptosis, Blotting, Western, Cell Hypoxia, Cell Survival, Cells, Cultured, Cyclin-Dependent Kinase Inhibitor p21, Embryo, Mammalian, Eukaryotic Initiation Factor-2, Fibroblasts, G1 Phase, Mice, Mice, Knockout, Phosphorylation, Protein Serine-Threonine Kinases, Tumor Suppressor Protein p53, eIF-2 Kinase
Added June 14, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Li F, Pallan PS, Maier MA, Rajeev KG, Mathieu SL, Kreutz C, Fan Y, Sanghvi J, Micura R, Rozners E, Manoharan M, Egli M
(2007) Nucleic Acids Res 35: 6424-38
MeSH Terms: Argonaute Proteins, Base Pair Mismatch, Base Pairing, Crystallography, X-Ray, Eukaryotic Initiation Factor-2, Fluorobenzenes, HeLa Cells, Humans, Hydrogen Bonding, Models, Molecular, Nucleotides, Oligoribonucleotides, Osmotic Pressure, RNA Interference, RNA, Small Interfering, RNA-Induced Silencing Complex, Substrate Specificity, Thermodynamics
Added March 5, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response.
Jiang HY, Wek SA, McGrath BC, Lu D, Hai T, Harding HP, Wang X, Ron D, Cavener DR, Wek RC
(2004) Mol Cell Biol 24: 1365-77
MeSH Terms: Activating Transcription Factor 3, Activating Transcription Factor 4, Animals, CCAAT-Enhancer-Binding Proteins, Eukaryotic Initiation Factor-2, Mice, Phosphorylation, Phosphotransferases, Protein Kinases, Protein Serine-Threonine Kinases, RNA, Messenger, Transcription Factor CHOP, Transcription Factors, eIF-2 Kinase
Added August 13, 2010
1 Communities
0 Members
0 Resources
14 MeSH Terms
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses.
Jiang HY, Wek SA, McGrath BC, Scheuner D, Kaufman RJ, Cavener DR, Wek RC
(2003) Mol Cell Biol 23: 5651-63
MeSH Terms: Animals, Apoptosis, Cell Nucleus, Cells, Cultured, Cycloheximide, Dactinomycin, Dose-Response Relationship, Drug, Endoplasmic Reticulum, Enzyme Activation, Eukaryotic Initiation Factor-2, Heterozygote, Immunoblotting, Luciferases, Mice, Microscopy, Confocal, Microscopy, Fluorescence, NF-kappa B, Phosphorylation, Protein Biosynthesis, Protein Synthesis Inhibitors, Protein Transport, Thapsigargin, Transcription, Genetic, Transcriptional Activation
Added August 13, 2010
1 Communities
0 Members
0 Resources
24 MeSH Terms
The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.
Zhang P, McGrath BC, Reinert J, Olsen DS, Lei L, Gill S, Wek SA, Vattem KM, Wek RC, Kimball SR, Jefferson LS, Cavener DR
(2002) Mol Cell Biol 22: 6681-8
MeSH Terms: Adaptation, Physiological, Animals, Animals, Newborn, Cells, Cultured, Eukaryotic Initiation Factor-2, Eukaryotic Initiation Factor-2B, Female, Fetal Viability, Food, Formulated, Gene Expression Regulation, Gene Targeting, Glycine, Heterozygote, Homozygote, Leucine, Liver, Mice, Mice, Knockout, Phosphorylation, Pregnancy, Prenatal Exposure Delayed Effects, Protein Kinases, Protein Serine-Threonine Kinases, Protein Subunits, Stem Cells, Tryptophan
Added August 13, 2010
1 Communities
0 Members
0 Resources
26 MeSH Terms
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas.
Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McNaughton K, Cavener DR
(2002) Mol Cell Biol 22: 3864-74
MeSH Terms: Animals, Apoptosis, Bone Development, Bone Diseases, Developmental, Cell Survival, Collagen Type I, Diabetes Mellitus, Endoplasmic Reticulum, Rough, Eukaryotic Initiation Factor-2, Gene Expression, Glucose, Growth Disorders, Humans, Mice, Mice, Knockout, Pancreas, Phosphorylation, eIF-2 Kinase
Added January 6, 2014
2 Communities
1 Members
0 Resources
18 MeSH Terms