Other search tools

About this data

The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

If you have any questions or comments, please contact us.

Results: 1 to 10 of 24

Publication Record

Connections

Formation of S-[2-(N-Deoxyadenosinyl)ethyl]glutathione in DNA and Replication Past the Adduct by Translesion DNA Polymerases.
Sedgeman CA, Su Y, Guengerich FP
(2017) Chem Res Toxicol 30: 1188-1196
MeSH Terms: Animals, Cattle, Chromatography, Liquid, DNA Adducts, DNA Replication, DNA-Directed DNA Polymerase, Ethylene Dibromide, Glutathione, Tandem Mass Spectrometry
Added March 14, 2018
0 Communities
1 Members
0 Resources
9 MeSH Terms
In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice.
Cho SH, Guengerich FP
(2013) Chem Res Toxicol 26: 1765-74
MeSH Terms: Animals, Butadienes, Buthionine Sulfoximine, Chromatography, High Pressure Liquid, DNA Adducts, DNA Mutational Analysis, Epoxy Compounds, Ethylene Dibromide, Glutathione, Glutathione Transferase, Guanine, Liver, Male, Mice, Mice, Transgenic, Mutagenicity Tests, Mutation, Mutation Rate, O(6)-Methylguanine-DNA Methyltransferase, Spectrometry, Mass, Electrospray Ionization
Added March 7, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations.
Loecken EM, Guengerich FP
(2008) Chem Res Toxicol 21: 453-8
MeSH Terms: Cell Survival, Cross-Linking Reagents, DNA, Environmental Pollutants, Epoxy Compounds, Escherichia coli, Ethylene Dibromide, Glyceraldehyde-3-Phosphate Dehydrogenases, Humans, Mutagens, Mutation, O(6)-Methylguanine-DNA Methyltransferase, Recombinant Proteins, Sulfhydryl Compounds
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Analysis of DNA adducts formed in vivo in rats and mice from 1,2-dibromoethane, 1,2-dichloroethane, dibromomethane, and dichloromethane using HPLC/accelerator mass spectrometry and relevance to risk estimates.
Watanabe K, Liberman RG, Skipper PL, Tannenbaum SR, Guengerich FP
(2007) Chem Res Toxicol 20: 1594-600
MeSH Terms: Animals, Chromatography, High Pressure Liquid, DNA Adducts, Ethylene Dibromide, Ethylene Dichlorides, Female, Hydrocarbons, Brominated, Kidney, Liver, Male, Mass Spectrometry, Methylene Chloride, Mice, Rats, Research Design, Risk Assessment
Added March 5, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane.
Liu L, Watanabe K, Fang Q, Williams KM, Guengerich FP, Pegg AE
(2007) Chem Res Toxicol 20: 155-63
MeSH Terms: Binding Sites, Chromatography, High Pressure Liquid, Electrophoresis, Polyacrylamide Gel, Escherichia coli, Ethylene Dibromide, Half-Life, Mutagens, O(6)-Methylguanine-DNA Methyltransferase, Point Mutation, Spectrometry, Mass, Electrospray Ionization
Added March 26, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation.
Guengerich FP
(2005) Arch Biochem Biophys 433: 369-78
MeSH Terms: Aflatoxin B1, Animals, Biotransformation, Butadienes, Cross-Linking Reagents, DNA, DNA Adducts, DNA Damage, DNA Repair, Dose-Response Relationship, Drug, Enzyme Activation, Escherichia coli, Ethylene Dibromide, Forecasting, Genes, Bacterial, Glutathione, Half-Life, Humans, Hydrolysis, Kinetics, Lysine, Models, Chemical, Molecular Structure, Mutagenicity Tests, Mutagens, Mutation, O(6)-Methylguanine-DNA Methyltransferase, Oxidation-Reduction, Salmonella typhimurium, Signal Transduction, Tetrachloroethylene, Trichloroethylene
Added March 5, 2014
0 Communities
1 Members
0 Resources
32 MeSH Terms
Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.
Liu L, Hachey DL, Valadez G, Williams KM, Guengerich FP, Loktionova NA, Kanugula S, Pegg AE
(2004) J Biol Chem 279: 4250-9
MeSH Terms: Animals, Cattle, DNA Adducts, Ethylene Dibromide, Humans, In Vitro Techniques, Molecular Structure, Mutagens, O(6)-Methylguanine-DNA Methyltransferase, Recombinant Proteins, Salmonella typhimurium, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Added March 20, 2014
0 Communities
2 Members
0 Resources
12 MeSH Terms
Activation of dihaloalkanes by thiol-dependent mechanisms.
Guengerich FP
(2003) J Biochem Mol Biol 36: 20-7
MeSH Terms: DNA Adducts, Ethylene Dibromide, Glutathione, Humans, Hydrocarbons, Halogenated, Inactivation, Metabolic, O(6)-Methylguanine-DNA Methyltransferase, Sulfhydryl Compounds
Added March 5, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Microsomal oxidation of tribromoethylene and reactions of tribromoethylene oxide.
Yoshioka T, Krauser JA, Guengerich FP
(2002) Chem Res Toxicol 15: 1414-20
MeSH Terms: Animals, Epoxy Compounds, Ethylene Dibromide, Ethylenes, Hydrocarbons, Brominated, Hydrolysis, Inactivation, Metabolic, Microsomes, Liver, Oxidation-Reduction, Rats
Added March 5, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.
Liu L, Pegg AE, Williams KM, Guengerich FP
(2002) J Biol Chem 277: 37920-8
MeSH Terms: Amino Acid Substitution, Base Sequence, Cell Line, Cloning, Molecular, DNA Primers, DNA Repair, Escherichia coli, Ethylene Dibromide, Humans, Kinetics, Mutagenesis, Site-Directed, O(6)-Methylguanine-DNA Methyltransferase, Plasmids, Recombinant Proteins
Added May 26, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms