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Formation of S-[2-(N-Deoxyadenosinyl)ethyl]glutathione in DNA and Replication Past the Adduct by Translesion DNA Polymerases.
Sedgeman CA, Su Y, Guengerich FP
(2017) Chem Res Toxicol 30: 1188-1196
MeSH Terms: Animals, Cattle, Chromatography, Liquid, DNA Adducts, DNA Replication, DNA-Directed DNA Polymerase, Ethylene Dibromide, Glutathione, Tandem Mass Spectrometry
Added March 14, 2018
0 Communities
1 Members
0 Resources
9 MeSH Terms
In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice.
Cho SH, Guengerich FP
(2013) Chem Res Toxicol 26: 1765-74
MeSH Terms: Animals, Butadienes, Buthionine Sulfoximine, Chromatography, High Pressure Liquid, DNA Adducts, DNA Mutational Analysis, Epoxy Compounds, Ethylene Dibromide, Glutathione, Glutathione Transferase, Guanine, Liver, Male, Mice, Mice, Transgenic, Mutagenicity Tests, Mutation, Mutation Rate, O(6)-Methylguanine-DNA Methyltransferase, Spectrometry, Mass, Electrospray Ionization
Added March 7, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations.
Loecken EM, Guengerich FP
(2008) Chem Res Toxicol 21: 453-8
MeSH Terms: Cell Survival, Cross-Linking Reagents, DNA, Environmental Pollutants, Epoxy Compounds, Escherichia coli, Ethylene Dibromide, Glyceraldehyde-3-Phosphate Dehydrogenases, Humans, Mutagens, Mutation, O(6)-Methylguanine-DNA Methyltransferase, Recombinant Proteins, Sulfhydryl Compounds
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Analysis of DNA adducts formed in vivo in rats and mice from 1,2-dibromoethane, 1,2-dichloroethane, dibromomethane, and dichloromethane using HPLC/accelerator mass spectrometry and relevance to risk estimates.
Watanabe K, Liberman RG, Skipper PL, Tannenbaum SR, Guengerich FP
(2007) Chem Res Toxicol 20: 1594-600
MeSH Terms: Animals, Chromatography, High Pressure Liquid, DNA Adducts, Ethylene Dibromide, Ethylene Dichlorides, Female, Hydrocarbons, Brominated, Kidney, Liver, Male, Mass Spectrometry, Methylene Chloride, Mice, Rats, Research Design, Risk Assessment
Added March 5, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane.
Liu L, Watanabe K, Fang Q, Williams KM, Guengerich FP, Pegg AE
(2007) Chem Res Toxicol 20: 155-63
MeSH Terms: Binding Sites, Chromatography, High Pressure Liquid, Electrophoresis, Polyacrylamide Gel, Escherichia coli, Ethylene Dibromide, Half-Life, Mutagens, O(6)-Methylguanine-DNA Methyltransferase, Point Mutation, Spectrometry, Mass, Electrospray Ionization
Added March 26, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation.
Guengerich FP
(2005) Arch Biochem Biophys 433: 369-78
MeSH Terms: Aflatoxin B1, Animals, Biotransformation, Butadienes, Cross-Linking Reagents, DNA, DNA Adducts, DNA Damage, DNA Repair, Dose-Response Relationship, Drug, Enzyme Activation, Escherichia coli, Ethylene Dibromide, Forecasting, Genes, Bacterial, Glutathione, Half-Life, Humans, Hydrolysis, Kinetics, Lysine, Models, Chemical, Molecular Structure, Mutagenicity Tests, Mutagens, Mutation, O(6)-Methylguanine-DNA Methyltransferase, Oxidation-Reduction, Salmonella typhimurium, Signal Transduction, Tetrachloroethylene, Trichloroethylene
Added March 5, 2014
0 Communities
1 Members
0 Resources
32 MeSH Terms
Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.
Liu L, Hachey DL, Valadez G, Williams KM, Guengerich FP, Loktionova NA, Kanugula S, Pegg AE
(2004) J Biol Chem 279: 4250-9
MeSH Terms: Animals, Cattle, DNA Adducts, Ethylene Dibromide, Humans, In Vitro Techniques, Molecular Structure, Mutagens, O(6)-Methylguanine-DNA Methyltransferase, Recombinant Proteins, Salmonella typhimurium, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Added March 20, 2014
0 Communities
2 Members
0 Resources
12 MeSH Terms
Activation of dihaloalkanes by thiol-dependent mechanisms.
Guengerich FP
(2003) J Biochem Mol Biol 36: 20-7
MeSH Terms: DNA Adducts, Ethylene Dibromide, Glutathione, Humans, Hydrocarbons, Halogenated, Inactivation, Metabolic, O(6)-Methylguanine-DNA Methyltransferase, Sulfhydryl Compounds
Added March 5, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Microsomal oxidation of tribromoethylene and reactions of tribromoethylene oxide.
Yoshioka T, Krauser JA, Guengerich FP
(2002) Chem Res Toxicol 15: 1414-20
MeSH Terms: Animals, Epoxy Compounds, Ethylene Dibromide, Ethylenes, Hydrocarbons, Brominated, Hydrolysis, Inactivation, Metabolic, Microsomes, Liver, Oxidation-Reduction, Rats
Added March 5, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.
Liu L, Pegg AE, Williams KM, Guengerich FP
(2002) J Biol Chem 277: 37920-8
MeSH Terms: Amino Acid Substitution, Base Sequence, Cell Line, Cloning, Molecular, DNA Primers, DNA Repair, Escherichia coli, Ethylene Dibromide, Humans, Kinetics, Mutagenesis, Site-Directed, O(6)-Methylguanine-DNA Methyltransferase, Plasmids, Recombinant Proteins
Added May 26, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms