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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 15

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Finding a Needle in a QT Interval Big Data Haystack: The Role for Orthogonal Datasets.
Roden DM, Mosley JD, Denny JC
(2016) J Am Coll Cardiol 68: 1765-1768
MeSH Terms: Ether-A-Go-Go Potassium Channels, Humans, Long QT Syndrome, Potassium Channels, Voltage-Gated, Torsades de Pointes
Added March 14, 2018
0 Communities
2 Members
0 Resources
5 MeSH Terms
Long QT Syndrome and Potentially Pathogenic Genetic Variants--In Reply.
Van Driest SL, Wells QS, Roden DM
(2016) JAMA 315: 2467-8
MeSH Terms: Arrhythmias, Cardiac, Electronic Health Records, Ether-A-Go-Go Potassium Channels, Female, Genetic Variation, Humans, Laboratories, Male, NAV1.5 Voltage-Gated Sodium Channel, Phenotype
Added April 6, 2017
0 Communities
2 Members
0 Resources
10 MeSH Terms
Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records.
Van Driest SL, Wells QS, Stallings S, Bush WS, Gordon A, Nickerson DA, Kim JH, Crosslin DR, Jarvik GP, Carrell DS, Ralston JD, Larson EB, Bielinski SJ, Olson JE, Ye Z, Kullo IJ, Abul-Husn NS, Scott SA, Bottinger E, Almoguera B, Connolly J, Chiavacci R, Hakonarson H, Rasmussen-Torvik LJ, Pan V, Persell SD, Smith M, Chisholm RL, Kitchner TE, He MM, Brilliant MH, Wallace JR, Doheny KF, Shoemaker MB, Li R, Manolio TA, Callis TE, Macaya D, Williams MS, Carey D, Kapplinger JD, Ackerman MJ, Ritchie MD, Denny JC, Roden DM
(2016) JAMA 315: 47-57
MeSH Terms: Aged, Aged, 80 and over, Alleles, Arrhythmias, Cardiac, Brugada Syndrome, ERG1 Potassium Channel, Electronic Health Records, Ether-A-Go-Go Potassium Channels, Female, Genetic Predisposition to Disease, Genetic Testing, Genetic Variation, Genomics, Heterozygote, Humans, Incidental Findings, Laboratories, Male, Middle Aged, Mutation, Missense, NAV1.5 Voltage-Gated Sodium Channel, Phenotype, Prospective Studies, Random Allocation, Statistics, Nonparametric, Young Adult
Added April 6, 2017
0 Communities
4 Members
0 Resources
26 MeSH Terms
Identification of a KCNQ1 polymorphism acting as a protective modifier against arrhythmic risk in long-QT syndrome.
Duchatelet S, Crotti L, Peat RA, Denjoy I, Itoh H, Berthet M, Ohno S, Fressart V, Monti MC, Crocamo C, Pedrazzini M, Dagradi F, Vicentini A, Klug D, Brink PA, Goosen A, Swan H, Toivonen L, Lahtinen AM, Kontula K, Shimizu W, Horie M, George AL, Trégouët DA, Guicheney P, Schwartz PJ
(2013) Circ Cardiovasc Genet 6: 354-61
MeSH Terms: Alleles, Case-Control Studies, Cohort Studies, Databases, Genetic, ERG1 Potassium Channel, Ether-A-Go-Go Potassium Channels, Female, Gene Frequency, Genotype, Heterozygote, Humans, KCNQ1 Potassium Channel, Long QT Syndrome, Male, Polymorphism, Single Nucleotide, Risk Factors
Added March 7, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias.
Potet F, Lorinc AN, Chaigne S, Hopkins CR, Venkataraman R, Stepanovic SZ, Lewis LM, Days E, Sidorov VY, Engers DW, Zou B, Afshartous D, George AL, Campbell CM, Balser JR, Li M, Baudenbacher FJ, Lindsley CW, Weaver CD, Kupershmidt S
(2012) J Biol Chem 287: 39613-25
MeSH Terms: Animals, Arrhythmias, Cardiac, Dose-Response Relationship, Drug, Drug Discovery, ERG1 Potassium Channel, Ether-A-Go-Go Potassium Channels, HEK293 Cells, Humans, Muscle Proteins, Myocardium, Naphthyridines, Phenethylamines, Potassium Channel Blockers, Pyridines, Rabbits, Structure-Activity Relationship, Sulfonamides
Added March 7, 2014
1 Communities
3 Members
0 Resources
17 MeSH Terms
Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.
Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY
(2012) Genes Dev 26: 1780-96
MeSH Terms: Animals, COS Cells, Cell Cycle Checkpoints, Cell Proliferation, Cell Size, Cells, Cultured, Chlorocebus aethiops, Enzyme Activation, Ether-A-Go-Go Potassium Channels, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, HEK293 Cells, Humans, MAP Kinase Signaling System, Medulloblastoma, Mice, Mitosis, Survival Analysis
Added January 18, 2013
0 Communities
2 Members
0 Resources
19 MeSH Terms
Cancer therapy-associated cardiotoxicity and signaling in the myocardium.
Zuppinger C, Suter TM
(2010) J Cardiovasc Pharmacol 56: 141-6
MeSH Terms: Angiogenesis Inhibitors, Anthracyclines, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, ERG1 Potassium Channel, ErbB Receptors, Ether-A-Go-Go Potassium Channels, Heart Diseases, Humans, Myocardium, Neoplasms, Neuregulin-1, Neuregulins, Receptor, ErbB-2, Receptor, ErbB-4, Signal Transduction, Trastuzumab
Added September 25, 2014
0 Communities
0 Members
1 Resources
18 MeSH Terms
KCNH2 pharmacogenomics summary.
Oshiro C, Thorn CF, Roden DM, Klein TE, Altman RB
(2010) Pharmacogenet Genomics 20: 775-7
MeSH Terms: ERG1 Potassium Channel, Ether-A-Go-Go Potassium Channels, Humans, Pharmacogenetics, Polymorphism, Single Nucleotide
Added June 26, 2014
0 Communities
1 Members
0 Resources
5 MeSH Terms
Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias.
Bush WS, Crawford DC, Alexander C, George AL, Roden DM, Ritchie MD
(2009) Pharmacogenomics 10: 1043-53
MeSH Terms: African Americans, Algorithms, Alleles, Ankyrins, Arrhythmias, Cardiac, Asian Continental Ancestry Group, Bayes Theorem, Cell Line, Cluster Analysis, DNA, ERG1 Potassium Channel, Ether-A-Go-Go Potassium Channels, European Continental Ancestry Group, Gene Frequency, Genetic Markers, Genetic Variation, Genetics, Population, Genome-Wide Association Study, Haplotypes, Humans, KCNQ1 Potassium Channel, Linkage Disequilibrium, Mexican Americans, Monte Carlo Method, Muscle Proteins, NAV1.5 Voltage-Gated Sodium Channel, Polymorphism, Single Nucleotide, Potassium Channels, Voltage-Gated, Ryanodine Receptor Calcium Release Channel, Sodium Channels, Software, United States
Added December 10, 2013
0 Communities
2 Members
0 Resources
32 MeSH Terms
The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel.
McBride BF, Yang T, Liu K, Urban TJ, Giacomini KM, Kim RB, Roden DM
(2009) J Cardiovasc Pharmacol 54: 63-71
MeSH Terms: Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Cation Transport Proteins, Electrophysiology, Ether-A-Go-Go Potassium Channels, Flecainide, Gene Expression, Heart, Humans, Immunohistochemistry, In Situ Hybridization, Inhibitory Concentration 50, Myocytes, Cardiac, Organic Cation Transport Proteins, Patch-Clamp Techniques, Potassium Channels, Quinidine, Sulfonamides, Symporters
Added June 26, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms