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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 40

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Selective Activation of N,N'-Diacyl Rhodamine Pro-fluorophores Paired with Releasing Enzyme, Porcine Liver Esterase (PLE).
Abney KK, Ramos-Hunter SJ, Romaine IM, Goodwin JS, Sulikowski GA, Weaver CD
(2018) Chemistry 24: 8985-8988
MeSH Terms: Animals, Esterases, HEK293 Cells, Humans, Liver, Microscopy, Confocal, Rhodamines, Spectrometry, Fluorescence, Swine
Added April 10, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Upregulation of SERT and ADORA1 in broilers with acute right ventricular failure.
Kamely M, Karimi Torshizi MA, Wideman RF, West J
(2019) Res Vet Sci 125: 397-400
MeSH Terms: Animals, Chickens, Cyclic Nucleotide Phosphodiesterases, Type 5, Gene Expression Regulation, Heart Failure, Hypertension, Pulmonary, Male, Myocardium, Poultry Diseases, Receptor, Adenosine A1, Serotonin Plasma Membrane Transport Proteins, Troponin T, Up-Regulation
Added April 2, 2019
0 Communities
1 Members
0 Resources
13 MeSH Terms
Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.
Richmond BW, Brucker RM, Han W, Du RH, Zhang Y, Cheng DS, Gleaves L, Abdolrasulnia R, Polosukhina D, Clark PE, Bordenstein SR, Blackwell TS, Polosukhin VV
(2016) Nat Commun 7: 11240
MeSH Terms: Aging, Airway Remodeling, Aminopyridines, Animals, Benzamides, Cyclic Nucleotide Phosphodiesterases, Type 4, Cyclopropanes, Disease Models, Animal, Gene Expression Regulation, Host-Pathogen Interactions, Humans, Immunity, Innate, Immunoglobulin A, Secretory, Leukocyte Elastase, Lung, Matrix Metalloproteinase 12, Mice, Mice, Inbred C57BL, Mice, Knockout, Microbiota, NF-kappa B, Phosphodiesterase 4 Inhibitors, Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema, Receptors, Polymeric Immunoglobulin, Respiratory Mucosa
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Development of thieno- and benzopyrimidinone inhibitors of the Hedgehog signaling pathway reveals PDE4-dependent and PDE4-independent mechanisms of action.
Hempel JE, Cadar AG, Hong CC
(2016) Bioorg Med Chem Lett 26: 1947-53
MeSH Terms: Cyclic Nucleotide Phosphodiesterases, Type 4, Dose-Response Relationship, Drug, HEK293 Cells, Hedgehog Proteins, Humans, Molecular Structure, Phosphodiesterase 4 Inhibitors, Pyrimidinones, Repressor Proteins, Signal Transduction, Smoothened Receptor, Structure-Activity Relationship
Added March 17, 2016
1 Communities
1 Members
0 Resources
12 MeSH Terms
An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition.
Williams CH, Hempel JE, Hao J, Frist AY, Williams MM, Fleming JT, Sulikowski GA, Cooper MK, Chiang C, Hong CC
(2015) Cell Rep 11: 43-50
MeSH Terms: Animals, Cyclic AMP-Dependent Protein Kinases, Cyclic Nucleotide Phosphodiesterases, Type 4, Hedgehog Proteins, Phosphodiesterase 4 Inhibitors, Pyrimidinones, Receptors, G-Protein-Coupled, Signal Transduction, Small Molecule Libraries, Smoothened Receptor, Thiophenes, Transcriptional Activation, Zebrafish, Zebrafish Proteins
Added April 5, 2015
1 Communities
3 Members
0 Resources
14 MeSH Terms
Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension.
Nozik-Grayck E, Woods C, Taylor JM, Benninger RK, Johnson RD, Villegas LR, Stenmark KR, Harrison DG, Majka SM, Irwin D, Farrow KN
(2014) Am J Physiol Lung Cell Mol Physiol 307: L868-76
MeSH Terms: Animals, Blood Pressure, Cyclic GMP, Cyclic Nucleotide Phosphodiesterases, Type 5, Estrogen Antagonists, GTP Cyclohydrolase, Guanylate Cyclase, Hypertension, Pulmonary, Hypertrophy, Right Ventricular, Hypoxia, Lung, Mice, Mice, Knockout, Nitric Oxide Synthase Type III, Pulmonary Artery, Receptors, Cytoplasmic and Nuclear, Signal Transduction, Soluble Guanylyl Cyclase, Superoxide Dismutase, Tamoxifen
Added March 31, 2015
1 Communities
2 Members
0 Resources
20 MeSH Terms
Loss of the histidine kinase DhkD results in mobile mounds during development of Dictyostelium discoideum.
Singleton CK, Xiong Y
(2013) PLoS One 8: e75618
MeSH Terms: 3',5'-Cyclic-AMP Phosphodiesterases, Cyclic AMP, Dictyostelium, Genome, Protozoan, Histidine Kinase, Phenotype, Protein Kinases, Protozoan Proteins
Added March 7, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model.
Tsunoda T, Ota T, Fujimoto T, Doi K, Tanaka Y, Yoshida Y, Ogawa M, Matsuzaki H, Hamabashiri M, Tyson DR, Kuroki M, Miyamoto S, Shirasawa S
(2012) Mol Cancer 11: 46
MeSH Terms: Apoptosis, Cell Line, Tumor, Cluster Analysis, Colorectal Neoplasms, Cyclic Nucleotide Phosphodiesterases, Type 4, Enzyme Activation, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genes, ras, HCT116 Cells, Humans, Phosphodiesterase 4 Inhibitors, Phosphorylation, Proto-Oncogene Proteins c-akt, RNA Interference, Recurrence, Rolipram, Spheroids, Cellular, Tight Junctions, Tumor Cells, Cultured
Added February 27, 2013
0 Communities
1 Members
0 Resources
20 MeSH Terms
Nitric oxide modulates bacterial biofilm formation through a multicomponent cyclic-di-GMP signaling network.
Plate L, Marletta MA
(2012) Mol Cell 46: 449-60
MeSH Terms: 3',5'-Cyclic-GMP Phosphodiesterases, Amino Acid Sequence, Bacterial Proteins, Biofilms, Cyclic GMP, Gammaproteobacteria, Guanylate Cyclase, Histidine Kinase, Models, Biological, Molecular Sequence Data, Nitric Oxide, Phosphorylation, Protein Kinases, Protein Structure, Tertiary, Receptors, Cytoplasmic and Nuclear, Second Messenger Systems, Sequence Homology, Amino Acid, Shewanella, Signal Transduction, Soluble Guanylyl Cyclase
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Effect of a phosphodiesterase 5 inhibitor on pulmonary and cerebral arteries of newborn piglets with chronic hypoxia-induced pulmonary hypertension.
Fike CD, Kaplowitz M, Zhang Y, Dantuma M, Madden JA
(2012) Neonatology 101: 28-39
MeSH Terms: 3',5'-Cyclic-AMP Phosphodiesterases, Animals, Animals, Newborn, Chronic Disease, Disease Models, Animal, Hypertension, Pulmonary, Hypoxia, Middle Cerebral Artery, Phosphodiesterase Inhibitors, Pulmonary Artery, Purinones, Swine, Vasodilation
Added May 20, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms