Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer.
Dosch AR, Dai X, Reyzer ML, Mehra S, Srinivasan S, Willobee BA, Kwon D, Kashikar N, Caprioli R, Merchant NB, Nagathihalli NS
(2020) Mol Cancer Res 18
: 623-631MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Pancreatic Ductal, Dasatinib, Deoxycytidine, Disease Models, Animal, ErbB Receptors, Erlotinib Hydrochloride, Female, Humans, Mice, Mice, Nude, Pancreatic Neoplasms, Protein Kinase Inhibitors, STAT3 Transcription Factor, Signal Transduction, Stromal Cells, Survival Analysis, Xenograft Model Antitumor Assays, src-Family KinasesAdded March 3, 2020
20 MeSH Terms
The Role of the EGF Receptor in Sex Differences in Kidney Injury.
Zhang MZ, Sasaki K, Li Y, Li Z, Pan Y, Jin GN, Wang Y, Niu A, Wang S, Fan X, Chen JC, Borza C, Yang H, Pozzi A, Fogo AB, Harris RC
(2019) J Am Soc Nephrol 30
: 1659-1673MeSH Terms: Age Factors, Alleles, Animals, Castration, Cell Line, ErbB Receptors, Erlotinib Hydrochloride, Female, Gain of Function Mutation, Humans, Kidney, Male, Mice, Mice, Inbred C57BL, Middle Aged, Ovariectomy, Podocytes, Protein Kinase Inhibitors, RNA, Messenger, Renal Insufficiency, Chronic, Sex Factors, TestosteroneAdded August 7, 2019
22 MeSH Terms
Inhibition of Epidermal Growth Factor Receptor Activation Is Associated With Improved Diabetic Nephropathy and Insulin Resistance in Type 2 Diabetes.
Li Z, Li Y, Overstreet JM, Chung S, Niu A, Fan X, Wang S, Wang Y, Zhang MZ, Harris RC
(2018) Diabetes 67
: 1847-1857MeSH Terms: Albuminuria, Animals, Biomarkers, Crosses, Genetic, Cytokines, Diabetes Mellitus, Type 2, Diabetic Nephropathies, ErbB Receptors, Erlotinib Hydrochloride, Fibrosis, Glomerulonephritis, Hypoglycemic Agents, Insulin Resistance, Kidney, Macrophages, Membrane Transport Modulators, Mice, Knockout, Mice, Mutant Strains, Nitric Oxide Synthase Type III, Oxidative Stress, Protein Kinase Inhibitors, T-Lymphocytes, Transforming Growth Factor alphaAdded November 9, 2018
23 MeSH Terms
A phase 1b study of erlotinib in combination with gemcitabine and nab-paclitaxel in patients with previously untreated advanced pancreatic cancer: an Academic Oncology GI Cancer Consortium study.
Cohen SJ, O'Neil BH, Berlin J, Ames P, McKinley M, Horan J, Catalano PM, Davies A, Weekes CD, Leichman L
(2016) Cancer Chemother Pharmacol 77
: 693-701MeSH Terms: Aged, Albumins, Antineoplastic Combined Chemotherapy Protocols, Deoxycytidine, Erlotinib Hydrochloride, Female, Humans, Male, Middle Aged, Paclitaxel, Pancreatic NeoplasmsAdded May 7, 2016
11 MeSH Terms
Serum Metabolite Profiles Are Altered by Erlotinib Treatment and the Integrin α1-Null Genotype but Not by Post-Traumatic Osteoarthritis.
Mickiewicz B, Shin SY, Pozzi A, Vogel HJ, Clark AL
(2016) J Proteome Res 15
: 815-25MeSH Terms: Animals, ErbB Receptors, Erlotinib Hydrochloride, Female, Integrin alpha1, Male, Menisci, Tibial, Metabolome, Mice, Mice, Knockout, Osteoarthritis, Knee, Reactive Oxygen Species, Transient Receptor Potential ChannelsAdded October 30, 2016
13 MeSH Terms
EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer.
Amato KR, Wang S, Tan L, Hastings AK, Song W, Lovly CM, Meador CB, Ye F, Lu P, Balko JM, Colvin DC, Cates JM, Pao W, Gray NS, Chen J
(2016) Cancer Res 76
: 305-18MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Benzamides, Cell Line, Tumor, Cell Proliferation, Drug Resistance, Neoplasm, Drug Synergism, ErbB Receptors, Erlotinib Hydrochloride, Humans, Lung Neoplasms, Mice, Mice, Nude, Niacinamide, Protein Kinase Inhibitors, Receptor, EphA2, Signal Transduction, Xenograft Model Antitumor AssaysAdded January 26, 2016
19 MeSH Terms
A phase II trial of erlotinib and bevacizumab for patients with metastatic melanoma.
Mudigonda TV, Wyman K, Spigel DR, Dahlman KB, Greco FA, Puzanov I, Kelley MC, Hainsworth JD, Sosman JA, Johnson DB
(2016) Pigment Cell Melanoma Res 29
: 101-3MeSH Terms: Antineoplastic Combined Chemotherapy Protocols, Bevacizumab, Disease-Free Survival, Erlotinib Hydrochloride, Humans, Melanoma, Neoplasm Metastasis, Treatment OutcomeAdded February 16, 2016
8 MeSH Terms
LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small-cell lung cancer (NSCLC) cells.
Whang YM, Park SI, Trenary IA, Egnatchik RA, Fessel JP, Kaufman JM, Carbone DP, Young JD
(2016) Oncogene 35
: 856-66MeSH Terms: Animals, Antineoplastic Agents, Blotting, Western, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Cell Survival, Drug Resistance, Neoplasm, Energy Metabolism, Erlotinib Hydrochloride, Female, Flow Cytometry, Gene Knockdown Techniques, Humans, Lung Neoplasms, Mice, Mice, Nude, Mutation, Protein-Serine-Threonine Kinases, RNA, Small Interfering, Signal Transduction, Transfection, Xenograft Model Antitumor AssaysAdded October 28, 2015
22 MeSH Terms
Derivation and experimental comparison of cell-division probability densities.
Leander R, Allen EJ, Garbett SP, Tyson DR, Quaranta V
(2014) J Theor Biol 359
: 129-35MeSH Terms: Antineoplastic Agents, Cell Count, Cell Cycle, Cell Division, Cell Proliferation, Cycloheximide, Dimethyl Sulfoxide, Erlotinib Hydrochloride, Humans, Models, Theoretical, Neoplasms, Probability, Quinazolines, Stochastic ProcessesAdded February 19, 2015
14 MeSH Terms
Epidermal growth factor receptor inhibition slows progression of diabetic nephropathy in association with a decrease in endoplasmic reticulum stress and an increase in autophagy.
Zhang MZ, Wang Y, Paueksakon P, Harris RC
(2014) Diabetes 63
: 2063-72MeSH Terms: AMP-Activated Protein Kinases, Albuminuria, Animals, Apoptosis, Autophagy, Blood Glucose, Blood Pressure, Cells, Cultured, Diabetes Mellitus, Experimental, Diabetic Nephropathies, Disease Progression, Endoplasmic Reticulum Stress, ErbB Receptors, Erlotinib Hydrochloride, Immunohistochemistry, Kidney, Mice, Mice, Inbred NOD, Phosphorylation, Protein Kinase Inhibitors, Quinazolines, Signal TransductionAdded October 27, 2014
22 MeSH Terms