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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 427

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Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer.
Dosch AR, Dai X, Reyzer ML, Mehra S, Srinivasan S, Willobee BA, Kwon D, Kashikar N, Caprioli R, Merchant NB, Nagathihalli NS
(2020) Mol Cancer Res 18: 623-631
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Pancreatic Ductal, Dasatinib, Deoxycytidine, Disease Models, Animal, ErbB Receptors, Erlotinib Hydrochloride, Female, Humans, Mice, Mice, Nude, Pancreatic Neoplasms, Protein Kinase Inhibitors, STAT3 Transcription Factor, Signal Transduction, Stromal Cells, Survival Analysis, Xenograft Model Antitumor Assays, src-Family Kinases
Added March 3, 2020
0 Communities
1 Members
0 Resources
20 MeSH Terms
Identification and Characterization of Unique Neutralizing Antibodies to Mouse EGF Receptor.
Jae Huh W, Niitsu H, Carney B, McKinley ET, Houghton JL, Coffey RJ
(2020) Gastroenterology 158: 1500-1502
MeSH Terms: Animals, Antibodies, Monoclonal, Humanized, Antibodies, Neutralizing, Azoxymethane, Carcinogens, Cells, Cultured, Colonic Neoplasms, Dextran Sulfate, Disease Models, Animal, ErbB Receptors, Gastritis, Hypertrophic, Genes, Reporter, Hepatocytes, Humans, Mice, Mice, Transgenic, Primary Cell Culture
Added January 31, 2020
1 Communities
1 Members
0 Resources
17 MeSH Terms
The Role of the EGF Receptor in Sex Differences in Kidney Injury.
Zhang MZ, Sasaki K, Li Y, Li Z, Pan Y, Jin GN, Wang Y, Niu A, Wang S, Fan X, Chen JC, Borza C, Yang H, Pozzi A, Fogo AB, Harris RC
(2019) J Am Soc Nephrol 30: 1659-1673
MeSH Terms: Age Factors, Alleles, Animals, Castration, Cell Line, ErbB Receptors, Erlotinib Hydrochloride, Female, Gain of Function Mutation, Humans, Kidney, Male, Mice, Mice, Inbred C57BL, Middle Aged, Ovariectomy, Podocytes, Protein Kinase Inhibitors, RNA, Messenger, Renal Insufficiency, Chronic, Sex Factors, Testosterone
Added August 7, 2019
1 Communities
0 Members
0 Resources
22 MeSH Terms
Transfer of Functional Cargo in Exomeres.
Zhang Q, Higginbotham JN, Jeppesen DK, Yang YP, Li W, McKinley ET, Graves-Deal R, Ping J, Britain CM, Dorsett KA, Hartman CL, Ford DA, Allen RM, Vickers KC, Liu Q, Franklin JL, Bellis SL, Coffey RJ
(2019) Cell Rep 27: 940-954.e6
MeSH Terms: Amphiregulin, Animals, Cell Line, Tumor, Colonic Neoplasms, Dogs, ErbB Receptors, Exosomes, Humans, Lipids, Madin Darby Canine Kidney Cells, Mice, Mice, Knockout, Nanoparticles, Nucleic Acids, Particle Size, Principal Component Analysis, Proteome, Proteomics, Sialyltransferases
Added April 24, 2019
1 Communities
1 Members
0 Resources
19 MeSH Terms
Protein kinase A-mediated phosphorylation of naked cuticle homolog 2 stimulates cell-surface delivery of transforming growth factor-α for epidermal growth factor receptor transactivation.
Cao Z, Singh B, Li C, Markham NO, Carrington LJ, Franklin JL, Graves-Deal R, Kennedy EJ, Goldenring JR, Coffey RJ
(2019) Traffic 20: 357-368
MeSH Terms: A Kinase Anchor Proteins, Adaptor Proteins, Signal Transducing, Animals, Caco-2 Cells, Calcium-Binding Proteins, Cell Cycle Proteins, Cell Membrane, Cyclic AMP-Dependent Protein Kinases, Dinoprostone, Dogs, ErbB Receptors, HEK293 Cells, Humans, Madin Darby Canine Kidney Cells, Protein Transport, Signal Transduction, Transforming Growth Factor alpha, Vasoactive Intestinal Peptide
Added March 3, 2020
0 Communities
1 Members
0 Resources
18 MeSH Terms
On-target Resistance to the Mutant-Selective EGFR Inhibitor Osimertinib Can Develop in an Allele-Specific Manner Dependent on the Original EGFR-Activating Mutation.
Brown BP, Zhang YK, Westover D, Yan Y, Qiao H, Huang V, Du Z, Smith JA, Ross JS, Miller VA, Ali S, Bazhenova L, Schrock AB, Meiler J, Lovly CM
(2019) Clin Cancer Res 25: 3341-3351
MeSH Terms: Acrylamides, Alleles, Aniline Compounds, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Dose-Response Relationship, Drug, Drug Resistance, Neoplasm, ErbB Receptors, Exons, Gene Expression Profiling, Humans, Lung Neoplasms, Models, Molecular, Mutation, Protein Binding, Protein Kinase Inhibitors, Structure-Activity Relationship
Added March 21, 2020
0 Communities
2 Members
0 Resources
17 MeSH Terms
Inhibition of Epidermal Growth Factor Receptor Activation Is Associated With Improved Diabetic Nephropathy and Insulin Resistance in Type 2 Diabetes.
Li Z, Li Y, Overstreet JM, Chung S, Niu A, Fan X, Wang S, Wang Y, Zhang MZ, Harris RC
(2018) Diabetes 67: 1847-1857
MeSH Terms: Albuminuria, Animals, Biomarkers, Crosses, Genetic, Cytokines, Diabetes Mellitus, Type 2, Diabetic Nephropathies, ErbB Receptors, Erlotinib Hydrochloride, Fibrosis, Glomerulonephritis, Hypoglycemic Agents, Insulin Resistance, Kidney, Macrophages, Membrane Transport Modulators, Mice, Knockout, Mice, Mutant Strains, Nitric Oxide Synthase Type III, Oxidative Stress, Protein Kinase Inhibitors, T-Lymphocytes, Transforming Growth Factor alpha
Added November 9, 2018
1 Communities
0 Members
0 Resources
23 MeSH Terms
Supplementation of p40, a Lactobacillus rhamnosus GG-derived protein, in early life promotes epidermal growth factor receptor-dependent intestinal development and long-term health outcomes.
Shen X, Liu L, Peek RM, Acra SA, Moore DJ, Wilson KT, He F, Polk DB, Yan F
(2018) Mucosal Immunol 11: 1316-1328
MeSH Terms: Animals, Bacterial Proteins, Cell Differentiation, Cell Proliferation, Epithelial Cells, ErbB Receptors, Female, Hydrogels, Immunity, Innate, Immunoglobulin A, Intestinal Mucosa, Lactobacillus rhamnosus, Mice, Mice, Inbred C57BL, Probiotics, T-Lymphocytes, Regulatory, Tight Junctions, Time, Transcriptional Activation
Added June 8, 2018
0 Communities
2 Members
0 Resources
19 MeSH Terms
amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics.
Fan PD, Narzisi G, Jayaprakash AD, Venturini E, Robine N, Smibert P, Germer S, Yu HA, Jordan EJ, Paik PK, Janjigian YY, Chaft JE, Wang L, Jungbluth AA, Middha S, Spraggon L, Qiao H, Lovly CM, Kris MG, Riely GJ, Politi K, Varmus H, Ladanyi M
(2018) Proc Natl Acad Sci U S A 115: E6030-E6038
MeSH Terms: Cell Line, Tumor, DNA Transposable Elements, Drug Resistance, Neoplasm, Enzyme Inhibitors, ErbB Receptors, Gene Amplification, Gene Expression Regulation, Neoplastic, Humans, Lung Neoplasms, Proto-Oncogene Proteins c-fyn, Proto-Oncogene Proteins c-yes, Proto-Oncogene Proteins pp60(c-src)
Added September 10, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity.
Löf-Öhlin ZM, Nyeng P, Bechard ME, Hess K, Bankaitis E, Greiner TU, Ameri J, Wright CV, Semb H
(2017) Nat Cell Biol 19: 1313-1325
MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Cell Differentiation, Cell Polarity, Epithelial Cells, ErbB Receptors, Insulin-Secreting Cells, Mice, Mice, Knockout, Morphogenesis, Nerve Tissue Proteins, Neuropeptides, Organogenesis, Phosphatidylinositol 3-Kinases, Protein Kinase C, Signal Transduction, rac1 GTP-Binding Protein
Added November 7, 2017
1 Communities
1 Members
0 Resources
17 MeSH Terms