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Results: 1 to 10 of 76

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Two polymorphic gene loci associated with treprostinil dose in pulmonary arterial hypertension.
Thomeas-McEwing V, Psotka MA, Gamazon ER, Friedman P, Konkashbaev A, Kubo M, Nakamura Y, Ratain MJ, Benza RL, Cox NJ, Gomberg-Maitland MI, Maitland ML
(2022) Pharmacogenet Genomics 32: 144-151
MeSH Terms: Antihypertensive Agents, Epoprostenol, Familial Primary Pulmonary Hypertension, Genome-Wide Association Study, Humans, Hypertension, Pulmonary, Pulmonary Arterial Hypertension
Added April 8, 2022
0 Communities
1 Members
0 Resources
7 MeSH Terms
Pulmonary Edema After Initiation of Parenteral Prostaglandin Therapy: More Common Than We Think but How Clinically Important Is It?
Robbins IM
(2019) Chest 156: 7-8
MeSH Terms: Epoprostenol, Humans, Prostaglandins, Pulmonary Arterial Hypertension, Pulmonary Edema, Retrospective Studies
Added March 8, 2020
0 Communities
1 Members
0 Resources
6 MeSH Terms
Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE (Prostaglandin E) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury.
Hao H, Hu S, Wan Q, Xu C, Chen H, Zhu L, Xu Z, Meng J, Breyer RM, Li N, Liu DP, FitzGerald GA, Wang M
(2018) Arterioscler Thromb Vasc Biol 38: 1115-1124
MeSH Terms: Animals, Cell Adhesion, Cell Proliferation, Cells, Cultured, Dinoprostone, Disease Models, Animal, Endothelial Cells, Female, Femoral Artery, Humans, Leukocytes, Male, Mice, Inbred C57BL, Mice, Knockout, Muscle, Smooth, Neointima, Prostaglandin-E Synthases, Re-Epithelialization, Receptors, Epoprostenol, Receptors, Prostaglandin E, EP4 Subtype, Signal Transduction, Vascular System Injuries
Added May 29, 2018
1 Communities
0 Members
0 Resources
22 MeSH Terms
Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung Inflammation.
Zhou W, Zhang J, Goleniewska K, Dulek DE, Toki S, Newcomb DC, Cephus JY, Collins RD, Wu P, Boothby MR, Peebles RS
(2016) J Immunol 197: 1577-86
MeSH Terms: Allergens, Animals, Antihypertensive Agents, Asthma, CD4-Positive T-Lymphocytes, Cell Proliferation, Chemokines, Epoprostenol, Hypersensitivity, Indomethacin, Inflammation, Interleukin-13, Interleukin-5, Lung, Lymphocyte Activation, Mice, Mice, Inbred BALB C, Mice, Knockout, Ovalbumin, Receptors, Epoprostenol, STAT6 Transcription Factor, Signal Transduction, Th2 Cells
Added March 14, 2018
0 Communities
1 Members
0 Resources
23 MeSH Terms
Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.
Kirkby NS, Reed DM, Edin ML, Rauzi F, Mataragka S, Vojnovic I, Bishop-Bailey D, Milne GL, Longhurst H, Zeldin DC, Mitchell JA, Warner TD
(2015) FASEB J 29: 4568-78
MeSH Terms: Adult, Antigens, Human Platelet, Blood Platelets, Dinoprostone, Endothelial Cells, Epoprostenol, Female, Humans, Leukocytes, Male, Mutation, Platelet Activation
Added March 10, 2016
1 Communities
0 Members
0 Resources
12 MeSH Terms
Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling.
Zhou W, Goleniewska K, Zhang J, Dulek DE, Toki S, Lotz MT, Newcomb DC, Boswell MG, Polosukhin VV, Milne GL, Wu P, Moore ML, FitzGerald GA, Peebles RS
(2014) J Allergy Clin Immunol 134: 698-705.e5
MeSH Terms: Air Pollution, Allergens, Animals, Enzyme Inhibitors, Epoprostenol, Humans, Hypersensitivity, Immune Tolerance, Indomethacin, Mice, Mice, 129 Strain, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Ovalbumin, Prostaglandin-Endoperoxide Synthases, Receptors, Epoprostenol, Signal Transduction
Added January 20, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Two formulations of epoprostenol sodium in the treatment of pulmonary arterial hypertension: EPITOME-1 (epoprostenol for injection in pulmonary arterial hypertension), a phase IV, open-label, randomized study.
Chin KM, Badesch DB, Robbins IM, Tapson VF, Palevsky HI, Kim NH, Kawut SM, Frost A, Benton WW, Lemarie JC, Bodin F, Rubin LJ, McLaughlin V
(2014) Am Heart J 167: 218-225.e1
MeSH Terms: Adolescent, Adult, Aged, Antihypertensive Agents, Dose-Response Relationship, Drug, Epoprostenol, Exercise Tolerance, Familial Primary Pulmonary Hypertension, Female, Follow-Up Studies, Hemodynamics, Humans, Hypertension, Pulmonary, Injections, Intravenous, Male, Middle Aged, Prospective Studies, Treatment Outcome, Young Adult
Added March 8, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Combination therapy in pulmonary arterial hypertension.
Pugh ME, Hemnes AR, Robbins IM
(2013) Clin Chest Med 34: 841-55
MeSH Terms: Drug Therapy, Combination, Endothelin Receptor Antagonists, Epoprostenol, Familial Primary Pulmonary Hypertension, Humans, Hypertension, Pulmonary, Phosphodiesterase 5 Inhibitors, Prostaglandins
Added March 8, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
PGI₂ signaling inhibits antigen uptake and increases migration of immature dendritic cells.
Toki S, Goleniewska K, Huckabee MM, Zhou W, Newcomb DC, Fitzgerald GA, Lawson WE, Peebles RS
(2013) J Leukoc Biol 94: 77-88
MeSH Terms: Animals, Bone Marrow Cells, Cell Movement, Chemokine CCL19, Chemokine CCL21, Chemotaxis, Cytokines, Dendritic Cells, Epoprostenol, Female, Flow Cytometry, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Ovalbumin, Platelet Aggregation Inhibitors, Receptors, CCR7, Receptors, Epoprostenol, Signal Transduction
Added May 27, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system.
Kirkby NS, Lundberg MH, Harrington LS, Leadbeater PD, Milne GL, Potter CM, Al-Yamani M, Adeyemi O, Warner TD, Mitchell JA
(2012) Proc Natl Acad Sci U S A 109: 17597-602
MeSH Terms: Animals, Blotting, Western, Cardiovascular System, Cells, Cultured, Cyclooxygenase 1, Cyclooxygenase 2, Endothelium, Vascular, Epoprostenol, Humans, Immunohistochemistry, Mice, Mice, Inbred C57BL, Mice, Knockout
Added March 26, 2014
1 Communities
1 Members
0 Resources
13 MeSH Terms