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Results: 1 to 10 of 10

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Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses.
Joyce MG, Wheatley AK, Thomas PV, Chuang GY, Soto C, Bailer RT, Druz A, Georgiev IS, Gillespie RA, Kanekiyo M, Kong WP, Leung K, Narpala SN, Prabhakaran MS, Yang ES, Zhang B, Zhang Y, Asokan M, Boyington JC, Bylund T, Darko S, Lees CR, Ransier A, Shen CH, Wang L, Whittle JR, Wu X, Yassine HM, Santos C, Matsuoka Y, Tsybovsky Y, Baxa U, NISC Comparative Sequencing Program, Mullikin JC, Subbarao K, Douek DC, Graham BS, Koup RA, Ledgerwood JE, Roederer M, Shapiro L, Kwong PD, Mascola JR, McDermott AB
(2016) Cell 166: 609-623
MeSH Terms: Adult, Amino Acid Sequence, Antibodies, Neutralizing, Antibodies, Viral, B-Lymphocytes, Epitopes, B-Lymphocyte, Female, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Humans, Immunologic Memory, Influenza A Virus, H5N1 Subtype, Influenza A virus, Influenza Vaccines, Male, Middle Aged, Models, Molecular, Protein Structure, Tertiary, Structure-Activity Relationship, Young Adult
Added May 3, 2017
0 Communities
1 Members
0 Resources
19 MeSH Terms
A new quaternary structure epitope on dengue virus serotype 2 is the target of durable type-specific neutralizing antibodies.
Gallichotte EN, Widman DG, Yount BL, Wahala WM, Durbin A, Whitehead S, Sariol CA, Crowe JE, de Silva AM, Baric RS
(2015) mBio 6: e01461-15
MeSH Terms: Antibodies, Neutralizing, Antibodies, Viral, Dengue Virus, Epitopes, B-Lymphocyte, Humans, Viral Envelope Proteins
Added January 26, 2016
0 Communities
1 Members
0 Resources
6 MeSH Terms
The potent and broadly neutralizing human dengue virus-specific monoclonal antibody 1C19 reveals a unique cross-reactive epitope on the bc loop of domain II of the envelope protein.
Smith SA, de Alwis AR, Kose N, Harris E, Ibarra KD, Kahle KM, Pfaff JM, Xiang X, Doranz BJ, de Silva AM, Austin SK, Sukupolvi-Petty S, Diamond MS, Crowe JE
(2013) mBio 4: e00873-13
MeSH Terms: Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Cross Reactions, Dengue Virus, Epitopes, B-Lymphocyte, Humans, Viral Envelope Proteins
Added March 20, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Epitope-specific human influenza antibody repertoires diversify by B cell intraclonal sequence divergence and interclonal convergence.
Krause JC, Tsibane T, Tumpey TM, Huffman CJ, Briney BS, Smith SA, Basler CF, Crowe JE
(2011) J Immunol 187: 3704-11
MeSH Terms: Amino Acid Sequence, Animals, Antibodies, Monoclonal, Antibody Specificity, Antigens, Viral, B-Lymphocytes, Cell Lineage, Clone Cells, Epitopes, B-Lymphocyte, Female, Genes, Immunoglobulin, Hemagglutinin Glycoproteins, Influenza Virus, Humans, Influenza A Virus, H1N1 Subtype, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Reverse Transcriptase Polymerase Chain Reaction
Added August 6, 2012
0 Communities
1 Members
0 Resources
18 MeSH Terms
Sulphilimine cross-links in Goodpasture's disease.
Vanacore R, Pedchenko V, Bhave G, Hudson BG
(2011) Clin Exp Immunol 164 Suppl 1: 4-6
MeSH Terms: Anti-Glomerular Basement Membrane Disease, Autoantigens, Collagen Type IV, Cross-Linking Reagents, Epitopes, B-Lymphocyte, Epitopes, T-Lymphocyte, Humans, Protein Conformation
Added December 10, 2013
1 Communities
4 Members
0 Resources
8 MeSH Terms
A role for collagen IV cross-links in conferring immune privilege to the Goodpasture autoantigen: structural basis for the crypticity of B cell epitopes.
Vanacore RM, Ham AJ, Cartailler JP, Sundaramoorthy M, Todd P, Pedchenko V, Sado Y, Borza DB, Hudson BG
(2008) J Biol Chem 283: 22737-48
MeSH Terms: Amino Acid Sequence, Anti-Glomerular Basement Membrane Disease, Autoantigens, Collagen Type IV, Conserved Sequence, Cross-Linking Reagents, Dimerization, Epitopes, B-Lymphocyte, Humans, Molecular Sequence Data, Protein Structure, Quaternary
Added December 10, 2013
1 Communities
5 Members
1 Resources
11 MeSH Terms
Immunodominance of the VH1-46 antibody gene segment in the primary repertoire of human rotavirus-specific B cells is reduced in the memory compartment through somatic mutation of nondominant clones.
Tian C, Luskin GK, Dischert KM, Higginbotham JN, Shepherd BE, Crowe JE
(2008) J Immunol 180: 3279-88
MeSH Terms: Adult, Antibodies, Viral, Antigens, Viral, B-Lymphocyte Subsets, Capsid Proteins, Clone Cells, Epitopes, B-Lymphocyte, Humans, Immunodominant Epitopes, Immunoglobulin Class Switching, Immunoglobulin Heavy Chains, Immunoglobulin Variable Region, Immunologic Memory, Middle Aged, Resting Phase, Cell Cycle, Rotavirus, Somatic Hypermutation, Immunoglobulin
Added August 6, 2012
0 Communities
1 Members
0 Resources
17 MeSH Terms
The alloantigenic sites of alpha3alpha4alpha5(IV) collagen: pathogenic X-linked alport alloantibodies target two accessible conformational epitopes in the alpha5NC1 domain.
Kang JS, Kashtan CE, Turner AN, Heidet L, Hudson BG, Borza DB
(2007) J Biol Chem 282: 10670-7
MeSH Terms: Adult, Collagen Type IV, Epitope Mapping, Epitopes, B-Lymphocyte, Humans, Isoantibodies, Isoantigens, Kidney Transplantation, Male, Nephritis, Nephritis, Hereditary, Protein Structure, Tertiary, Transplantation Chimera, Transplantation, Homologous
Added December 10, 2013
1 Communities
2 Members
0 Resources
14 MeSH Terms
Antigenic diversity among Helicobacter pylori vacuolating toxins.
Vinion-Dubiel AD, McClain MS, Cao P, Mernaugh RL, Cover TL
(2001) Infect Immun 69: 4329-36
MeSH Terms: Animals, Antibodies, Monoclonal, Antigenic Variation, Antigens, Bacterial, Bacterial Proteins, Bacterial Toxins, Epitope Mapping, Epitopes, B-Lymphocyte, Female, Helicobacter pylori, Mice, Mice, Inbred BALB C, Neutralization Tests, Recombinant Fusion Proteins
Added March 5, 2014
0 Communities
2 Members
0 Resources
14 MeSH Terms
Lymphocytes lacking I kappa B-alpha develop normally, but have selective defects in proliferation and function.
Chen CL, Singh N, Yull FE, Strayhorn D, Van Kaer L, Kerr LD
(2000) J Immunol 165: 5418-27
MeSH Terms: Animals, B-Lymphocytes, Cell Differentiation, Cell Division, Clone Cells, DNA-Binding Proteins, Epitopes, B-Lymphocyte, Fetal Tissue Transplantation, Fetus, Germinal Center, I-kappa B Proteins, Immunoglobulins, Liver, Liver Transplantation, Lymphocyte Activation, Lymphocyte Subsets, Lymphoproliferative Disorders, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, NF-KappaB Inhibitor alpha, NF-kappa B, Organ Specificity, Spleen, T-Lymphocytes, Transcriptional Activation
Added December 10, 2013
1 Communities
2 Members
0 Resources
27 MeSH Terms