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Host deficiency in ephrin-A1 inhibits breast cancer metastasis.
Shiuan E, Inala A, Wang S, Song W, Youngblood V, Chen J, Brantley-Sieders DM
(2020) F1000Res 9: 217
MeSH Terms: Animals, Ephrin-A1, Lung Neoplasms, Mice, Mice, Knockout, Neoplasm Metastasis, Neoplasm Recurrence, Local, Tumor Microenvironment
Added May 29, 2020
1 Communities
0 Members
0 Resources
8 MeSH Terms
The Ephrin-A1/EPHA2 Signaling Axis Regulates Glutamine Metabolism in HER2-Positive Breast Cancer.
Youngblood VM, Kim LC, Edwards DN, Hwang Y, Santapuram PR, Stirdivant SM, Lu P, Ye F, Brantley-Sieders DM, Chen J
(2016) Cancer Res 76: 1825-36
MeSH Terms: Animals, Breast Neoplasms, Cell Proliferation, Ephrin-A1, Female, Glutamine, Humans, Mice, Receptor, EphA2, Signal Transduction
Added February 7, 2019
1 Communities
0 Members
0 Resources
MeSH Terms
Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome.
Brantley-Sieders DM, Jiang A, Sarma K, Badu-Nkansah A, Walter DL, Shyr Y, Chen J
(2011) PLoS One 6: e24426
MeSH Terms: Breast Neoplasms, Ephrin-A1, Ephrins, Female, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, In Vitro Techniques, Receptor, EphA2, Receptor, EphA4, Receptor, EphA7, Receptor, EphB4, Receptor, EphB6, Tissue Array Analysis
Added February 13, 2014
1 Communities
3 Members
0 Resources
14 MeSH Terms
Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis.
Dunaway CM, Hwang Y, Lindsley CW, Cook RS, Wu JY, Boothby M, Chen J, Brantley-Sieders DM
(2011) Mol Cell Biol 31: 404-16
MeSH Terms: Animals, Carrier Proteins, Cattle, Cell Movement, Endothelial Cells, Enzyme Activation, Ephrin-A1, Genes, Dominant, HEK293 Cells, Humans, Intercellular Signaling Peptides and Proteins, Mice, Neovascularization, Physiologic, Nerve Tissue Proteins, Proto-Oncogene Proteins c-akt, Rapamycin-Insensitive Companion of mTOR Protein, Signal Transduction, Subcutaneous Tissue, Trans-Activators, Transcription Factors, rac GTP-Binding Proteins
Added December 10, 2013
2 Communities
3 Members
0 Resources
21 MeSH Terms
Regulation of heart valve morphogenesis by Eph receptor ligand, ephrin-A1.
Frieden LA, Townsend TA, Vaught DB, Delaughter DM, Hwang Y, Barnett JV, Chen J
(2010) Dev Dyn 239: 3226-34
MeSH Terms: Animals, Echocardiography, Ephrin-A1, Female, Heart, Heart Valves, Male, Mice, Mice, Knockout, Morphogenesis
Added November 13, 2013
2 Communities
2 Members
0 Resources
10 MeSH Terms
Regulation of mammary gland branching morphogenesis by EphA2 receptor tyrosine kinase.
Vaught D, Chen J, Brantley-Sieders DM
(2009) Mol Biol Cell 20: 2572-81
MeSH Terms: Animals, Apoptosis, Cell Proliferation, Ephrin-A1, Epithelial Cells, Epithelium, Hepatocyte Growth Factor, Ligands, Mammary Glands, Animal, Mice, Models, Biological, Morphogenesis, Receptor, EphA2, rhoA GTP-Binding Protein
Added March 5, 2014
1 Communities
2 Members
0 Resources
14 MeSH Terms
Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase.
Fang WB, Brantley-Sieders DM, Hwang Y, Ham AJ, Chen J
(2008) J Biol Chem 283: 16017-26
MeSH Terms: Amino Acid Substitution, Animals, Cell Movement, Endothelial Cells, Ephrin-A1, Guanine Nucleotide Exchange Factors, Mice, Mice, Transgenic, Mutation, Missense, Neoplasm Invasiveness, Neovascularization, Pathologic, Neuropeptides, Peptide Mapping, Phosphatidylinositol 3-Kinases, Phosphorylation, Protein Binding, Protein Structure, Tertiary, Proto-Oncogene Proteins c-vav, Receptor, EphA2, Signal Transduction, Tyrosine, rac GTP-Binding Proteins, rac1 GTP-Binding Protein
Added March 5, 2014
1 Communities
1 Members
0 Resources
23 MeSH Terms
Ephrin-A1 facilitates mammary tumor metastasis through an angiogenesis-dependent mechanism mediated by EphA receptor and vascular endothelial growth factor in mice.
Brantley-Sieders DM, Fang WB, Hwang Y, Hicks D, Chen J
(2006) Cancer Res 66: 10315-24
MeSH Terms: Adenocarcinoma, Animals, Cell Movement, Cells, Cultured, Endothelial Cells, Ephrin-A1, Female, Mammary Neoplasms, Experimental, Mice, Mice, Inbred BALB C, Neoplasm Metastasis, Neovascularization, Pathologic, Receptors, Eph Family, Vascular Endothelial Growth Factor A
Added March 5, 2014
1 Communities
1 Members
0 Resources
14 MeSH Terms
Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis.
Hunter SG, Zhuang G, Brantley-Sieders D, Swat W, Cowan CW, Chen J
(2006) Mol Cell Biol 26: 4830-42
MeSH Terms: Animals, Cell Movement, Cytoskeleton, Endothelial Cells, Enzyme Activation, Ephrin-A1, Guanine Nucleotide Exchange Factors, Mice, Mice, Mutant Strains, Neovascularization, Physiologic, Protein Interaction Mapping, Protein Structure, Tertiary, Proto-Oncogene Proteins c-vav, Receptor, EphA2, rac1 GTP-Binding Protein
Added March 5, 2014
1 Communities
1 Members
0 Resources
15 MeSH Terms
Inhibition of retinal neovascularization by soluble EphA2 receptor.
Chen J, Hicks D, Brantley-Sieders D, Cheng N, McCollum GW, Qi-Werdich X, Penn J
(2006) Exp Eye Res 82: 664-73
MeSH Terms: Animals, Animals, Newborn, Cell Division, Cells, Cultured, Disease Models, Animal, Endothelial Cells, Ephrin-A1, Humans, Immunohistochemistry, Infant, Newborn, Injections, Rats, Rats, Sprague-Dawley, Receptor, EphA2, Retina, Retinal Neovascularization, Retinal Vessels, Retinopathy of Prematurity, Vascular Endothelial Growth Factor A
Added March 5, 2014
1 Communities
2 Members
0 Resources
19 MeSH Terms