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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 558

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The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (/) of CK1α.
Shen C, Li B, Astudillo L, Deutscher MP, Cobb MH, Capobianco AJ, Lee E, Robbins DJ
(2019) Biochemistry 58: 5102-5106
MeSH Terms: Biocatalysis, Casein Kinase Ialpha, Enzyme Activation, HEK293 Cells, Humans, Kinetics, Pyrvinium Compounds
Added December 22, 2019
0 Communities
1 Members
0 Resources
7 MeSH Terms
A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation.
Sammons RM, Perry NA, Li Y, Cho EJ, Piserchio A, Zamora-Olivares DP, Ghose R, Kaoud TS, Debevec G, Bartholomeusz C, Gurevich VV, Iverson TM, Giulianotti M, Houghten RA, Dalby KN
(2019) ACS Chem Biol 14: 1183-1194
MeSH Terms: Binding Sites, Crystallography, X-Ray, Dose-Response Relationship, Drug, Enzyme Activation, Guanidine, Humans, Mitogen-Activated Protein Kinase 1, Nuclear Magnetic Resonance, Biomolecular, Phosphorylation, Protein Kinase Inhibitors, Substrate Specificity
Added March 18, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Matrix stiffness regulates vascular integrity through focal adhesion kinase activity.
Wang W, Lollis EM, Bordeleau F, Reinhart-King CA
(2019) FASEB J 33: 1199-1208
MeSH Terms: Adherens Junctions, Animals, Antigens, CD, Cadherins, Capillary Permeability, Chick Embryo, Endothelium, Vascular, Enzyme Activation, Extracellular Matrix, Female, Focal Adhesion Protein-Tyrosine Kinases, Human Umbilical Vein Endothelial Cells, Humans, Mice, Mice, Transgenic, Phosphorylation, Protein Transport, Tyrosine, src-Family Kinases
Added April 10, 2019
0 Communities
1 Members
0 Resources
19 MeSH Terms
A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL.
Cooke AL, Morris J, Melchior JT, Street SE, Jerome WG, Huang R, Herr AB, Smith LE, Segrest JP, Remaley AT, Shah AS, Thompson TB, Davidson WS
(2018) J Lipid Res 59: 1244-1255
MeSH Terms: Apolipoprotein A-I, Cholesterol, HDL, Enzyme Activation, Humans, Mutation, Phosphatidylcholine-Sterol O-Acyltransferase
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Autochthonous tumors driven by loss have an ongoing requirement for the RBP2 histone demethylase.
McBrayer SK, Olenchock BA, DiNatale GJ, Shi DD, Khanal J, Jennings RB, Novak JS, Oser MG, Robbins AK, Modiste R, Bonal D, Moslehi J, Bronson RT, Neuberg D, Nguyen QD, Signoretti S, Losman JA, Kaelin WG
(2018) Proc Natl Acad Sci U S A 115: E3741-E3748
MeSH Terms: Alleles, Animals, DNA-Binding Proteins, Echocardiography, Enzyme Activation, Fibroblasts, Genes, Retinoblastoma, Heart Septal Defects, Histone Code, Integrases, Jumonji Domain-Containing Histone Demethylases, Mice, Mice, Inbred C57BL, Molecular Targeted Therapy, Neoplasm Proteins, Pituitary Neoplasms, Recombinant Fusion Proteins, Retinoblastoma Protein, Tamoxifen, Thyroid Neoplasms, Transgenes
Added April 22, 2018
0 Communities
1 Members
0 Resources
21 MeSH Terms
Mechanisms of receptor tyrosine kinase activation in cancer.
Du Z, Lovly CM
(2018) Mol Cancer 17: 58
MeSH Terms: Animals, Cell Transformation, Neoplastic, Enzyme Activation, Gene Expression Regulation, Neoplastic, Humans, Ligands, Molecular Targeted Therapy, Mutation, Neoplasms, Phosphorylation, Protein Binding, Protein Interaction Domains and Motifs, Protein Kinase Inhibitors, Protein Multimerization, Receptor Protein-Tyrosine Kinases, Signal Transduction
Added September 10, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Oxidative stress, caspase-3 activation and cleavage of ROCK-1 play an essential role in MeHg-induced cell death in primary astroglial cells.
Dos Santos AA, López-Granero C, Farina M, Rocha JBT, Bowman AB, Aschner M
(2018) Food Chem Toxicol 113: 328-336
MeSH Terms: Animals, Astrocytes, Caspase 3, Caspase 9, Cell Death, Cells, Cultured, Enzyme Activation, Lim Kinases, Methylmercury Compounds, Mice, Inbred C57BL, Myosin-Light-Chain Phosphatase, Oxidative Stress, Phosphorylation, Proteolysis, rho-Associated Kinases
Added April 11, 2018
0 Communities
1 Members
0 Resources
15 MeSH Terms
Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.
Chung L, Thiele Orberg E, Geis AL, Chan JL, Fu K, DeStefano Shields CE, Dejea CM, Fathi P, Chen J, Finard BB, Tam AJ, McAllister F, Fan H, Wu X, Ganguly S, Lebid A, Metz P, Van Meerbeke SW, Huso DL, Wick EC, Pardoll DM, Wan F, Wu S, Sears CL, Housseau F
(2018) Cell Host Microbe 23: 203-214.e5
MeSH Terms: Adenomatous Polyposis Coli Protein, Animals, Bacterial Toxins, Bacteroides fragilis, Carcinogenesis, Cell Line, Tumor, Colon, Colorectal Neoplasms, Enzyme Activation, Epithelial Cells, Female, Gene Deletion, HT29 Cells, Humans, Inflammation, Interleukin-17, Male, Metalloendopeptidases, Mice, Mice, Inbred C57BL, Mice, Knockout, Myeloid Cells, Receptors, Interleukin-17, Receptors, Interleukin-8B, STAT3 Transcription Factor, Transcription Factor RelA
Added March 20, 2018
0 Communities
1 Members
0 Resources
26 MeSH Terms
TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis.
Fang J, Muto T, Kleppe M, Bolanos LC, Hueneman KM, Walker CS, Sampson L, Wellendorf AM, Chetal K, Choi K, Salomonis N, Choi Y, Zheng Y, Cancelas JA, Levine RL, Starczynowski DT
(2018) Cell Rep 22: 1250-1262
MeSH Terms: Animals, Enzyme Activation, Hematopoiesis, Hematopoietic Stem Cells, Homeostasis, I-kappa B Kinase, Mice, Mice, Transgenic, NF-kappa B, Signal Transduction, TNF Receptor-Associated Factor 6
Added February 26, 2018
0 Communities
1 Members
0 Resources
11 MeSH Terms
IKKβ Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis.
McCoy AM, Herington JL, Stouch AN, Mukherjee AB, Lakhdari O, Blackwell TS, Prince LS
(2017) Am J Pathol 187: 2635-2644
MeSH Terms: Animals, Enzyme Activation, I-kappa B Kinase, Lung, Mesoderm, Mice, Mice, Transgenic, Morphogenesis, NF-kappa B
Added March 21, 2018
0 Communities
2 Members
0 Resources
9 MeSH Terms