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Results: 1 to 3 of 3

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ERAD-icating mutant insulin promotes functional insulin secretion.
Moore DJ
(2017) Sci Transl Med 9:
MeSH Terms: Endoplasmic Reticulum, Endoplasmic Reticulum-Associated Degradation, Insulin, Insulin Secretion, Proinsulin, Protein Folding
Added January 20, 2017
0 Communities
1 Members
0 Resources
6 MeSH Terms
GABAA receptor biogenesis is impaired by the γ2 subunit febrile seizure-associated mutation, GABRG2(R177G).
Todd E, Gurba KN, Botzolakis EJ, Stanic AK, Macdonald RL
(2014) Neurobiol Dis 69: 215-24
MeSH Terms: Cell Membrane, Conserved Sequence, Cycloheximide, Endoplasmic Reticulum, Endoplasmic Reticulum-Associated Degradation, Glycosylation, HEK293 Cells, Humans, Models, Molecular, Mutation, Missense, Patch-Clamp Techniques, Protein Structure, Secondary, Protein Structure, Tertiary, Protein Synthesis Inhibitors, Protein Transport, Receptors, GABA-A, Seizures, Febrile, gamma-Aminobutyric Acid
Added January 24, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
The type II deiodinase is retrotranslocated to the cytoplasm and proteasomes via p97/Atx3 complex.
Arrojo E Drigo R, Egri P, Jo S, Gereben B, Bianco AC
(2013) Mol Endocrinol 27: 2105-15
MeSH Terms: Adenosine Triphosphatases, Ataxin-3, Cytoplasm, Endoplasmic Reticulum, Endoplasmic Reticulum-Associated Degradation, Enzyme Stability, HEK293 Cells, Humans, Iodide Peroxidase, Lysine, Nerve Tissue Proteins, Nuclear Proteins, Proteasome Endopeptidase Complex, Protein Transport, Repressor Proteins, Substrate Specificity, Ubiquitin, Ubiquitination
Added April 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms