Depletion of the C. elegans NAC engages the unfolded protein response, resulting in increased chaperone expression and apoptosis.
Arsenovic PT, Maldonado AT, Colleluori VD, Bloss TA
(2012) PLoS One 7
: e44038MeSH Terms: Animals, Caenorhabditis elegans, Endoplasmic Reticulum, Endoplasmic Reticulum Chaperone BiP, Gene Expression Regulation, Developmental, Heat-Shock Proteins, Hot Temperature, Intestinal Mucosa, Lysosomes, Molecular Chaperones, RNA Interference, Stress, Physiological, Unfolded Protein Response, Up-RegulationAdded April 25, 2013
14 MeSH Terms
Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells.
Sato Y, Hatta M, Karim MF, Sawa T, Wei FY, Sato S, Magnuson MA, Gonzalez FJ, Tomizawa K, Akaike T, Yoshizawa T, Yamagata K
(2012) J Biol Chem 287
: 23236-45MeSH Terms: Animals, Apoptosis, Carrier Proteins, Cell Line, Tumor, Diabetes Mellitus, Type 2, Endoplasmic Reticulum, Endoplasmic Reticulum Chaperone BiP, Endoplasmic Reticulum Stress, Female, Gene Expression Profiling, Heat-Shock Proteins, Insulin-Secreting Cells, Insulinoma, Intracellular Signaling Peptides and Proteins, Mice, Mice, Knockout, Pancreatic Neoplasms, Proteomics, Transcriptional ActivationAdded June 22, 2012
19 MeSH Terms
Phosphatidylethanolamines modified by γ-ketoaldehyde (γKA) induce endoplasmic reticulum stress and endothelial activation.
Guo L, Chen Z, Cox BE, Amarnath V, Epand RF, Epand RM, Davies SS
(2011) J Biol Chem 286
: 18170-80MeSH Terms: Cell Adhesion Molecules, Cell Line, Cell Membrane, Chemokine CCL2, Endoplasmic Reticulum, Endoplasmic Reticulum Chaperone BiP, Endothelial Cells, Heat-Shock Proteins, Humans, Interleukin-8, Lipid Bilayers, Lipid Peroxidation, Phosphatidylethanolamines, Transcription Factor CHOP, Unfolded Protein ResponseAdded June 1, 2013
15 MeSH Terms
Application of systems biology approach identifies and validates GRB2 as a risk gene for schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample.
Sun J, Wan C, Jia P, Fanous AH, Kendler KS, Riley BP, Zhao Z
(2011) Schizophr Res 125
: 201-8MeSH Terms: Alleles, Case-Control Studies, Endoplasmic Reticulum Chaperone BiP, Female, GRB2 Adaptor Protein, Gene Frequency, Genetic Predisposition to Disease, Genetics, Population, Genome-Wide Association Study, Genotype, Haplotypes, Humans, Ireland, Male, Northern Ireland, Polymorphism, Single Nucleotide, Psychotic Disorders, Risk Factors, Schizophrenia, Schizophrenic Psychology, Systems BiologyAdded March 5, 2014
21 MeSH Terms
Targeted nanoparticles that deliver a sustained, specific release of Paclitaxel to irradiated tumors.
Passarella RJ, Spratt DE, van der Ende AE, Phillips JG, Wu H, Sathiyakumar V, Zhou L, Hallahan DE, Harth E, Diaz R
(2010) Cancer Res 70
: 4550-9MeSH Terms: Animals, Antineoplastic Agents, Phytogenic, Apoptosis, Bacteriophages, Breast Neoplasms, Cell Growth Processes, Cell Line, Tumor, Coculture Techniques, Delayed-Action Preparations, Drug Delivery Systems, Endoplasmic Reticulum Chaperone BiP, Endothelial Cells, Glioma, Heat-Shock Proteins, Humans, Mice, Mice, Inbred C57BL, Mice, Nude, Nanoparticles, Oligopeptides, Paclitaxel, Recombinant Proteins, Xenograft Model Antitumor AssaysAdded February 15, 2016
23 MeSH Terms
Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection.
Lawson WE, Crossno PF, Polosukhin VV, Roldan J, Cheng DS, Lane KB, Blackwell TR, Xu C, Markin C, Ware LB, Miller GG, Loyd JE, Blackwell TS
(2008) Am J Physiol Lung Cell Mol Physiol 294
: L1119-26MeSH Terms: Antigens, Viral, Cells, Cultured, DNA-Binding Proteins, Endoplasmic Reticulum, Endoplasmic Reticulum Chaperone BiP, Glycoproteins, Heat-Shock Proteins, Herpesviridae Infections, Humans, Immunohistochemistry, Molecular Chaperones, Nuclear Proteins, Protein Folding, Pulmonary Alveoli, Pulmonary Fibrosis, Pulmonary Surfactant-Associated Protein C, Regulatory Factor X Transcription Factors, Stress, Physiological, Transcription Factors, alpha-MannosidaseAdded March 5, 2014
20 MeSH Terms
Proteasome function is required to maintain muscle cellular architecture.
Haas KF, Woodruff E, Broadie K
(2007) Biol Cell 99
: 615-26MeSH Terms: Animals, Animals, Genetically Modified, Cell Membrane, Cell Nucleus, Cytoplasm, Drosophila Proteins, Drosophila melanogaster, Endoplasmic Reticulum Chaperone BiP, Heat-Shock Proteins, Larva, Models, Genetic, Molecular Chaperones, Neuromuscular Junction, Proteasome Endopeptidase Complex, Proteasome Inhibitors, Protein Subunits, Sarcomeres, UbiquitinAdded February 12, 2015
18 MeSH Terms
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.
Ye J, Rawson RB, Komuro R, Chen X, Davé UP, Prywes R, Brown MS, Goldstein JL
(2000) Mol Cell 6
: 1355-64MeSH Terms: Activating Transcription Factor 6, Amino Acid Motifs, Amino Acid Sequence, Animals, CCAAT-Enhancer-Binding Proteins, Carrier Proteins, Cell Line, DNA-Binding Proteins, Endopeptidases, Endoplasmic Reticulum, Endoplasmic Reticulum Chaperone BiP, Heat-Shock Proteins, Humans, Immunoblotting, Intracellular Membranes, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Molecular Chaperones, Molecular Sequence Data, Mutation, Proprotein Convertases, Protein Binding, Protein Processing, Post-Translational, RNA, Messenger, Sequence Alignment, Serine Endopeptidases, Sterol Regulatory Element Binding Protein 1, Thapsigargin, Transcription Factors, Transcription, Genetic, TunicamycinAdded March 5, 2014
31 MeSH Terms