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The pore-forming subunit MCU of the mitochondrial Ca uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.
Georgiadou E, Haythorne E, Dickerson MT, Lopez-Noriega L, Pullen TJ, da Silva Xavier G, Davis SPX, Martinez-Sanchez A, Semplici F, Rizzuto R, McGinty JA, French PM, Cane MC, Jacobson DA, Leclerc I, Rutter GA
(2020) Diabetologia 63: 1368-1381
MeSH Terms: Animals, Blotting, Western, Calcium, Electrophoresis, Polyacrylamide Gel, Glucose, Insulin Secretion, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mitochondria
Added June 14, 2021
0 Communities
1 Members
0 Resources
11 MeSH Terms
Proteomic Analysis of S-Palmitoylated Proteins in Ocular Lens Reveals Palmitoylation of AQP5 and MP20.
Wang Z, Schey KL
(2018) Invest Ophthalmol Vis Sci 59: 5648-5658
MeSH Terms: Animals, Aquaporin 5, Blotting, Western, Cattle, Chromatography, Liquid, Electrophoresis, Polyacrylamide Gel, Eye Proteins, Immunoblotting, Lens, Crystalline, Lipoylation, Membrane Proteins, Palmitates, Proteomics, Tandem Mass Spectrometry
Added April 4, 2019
0 Communities
1 Members
0 Resources
14 MeSH Terms
Circulating Tumor Cells: Diagnostic and Therapeutic Applications.
Lin E, Cao T, Nagrath S, King MR
(2018) Annu Rev Biomed Eng 20: 329-352
MeSH Terms: Animals, Cell Separation, Electrophoresis, Epithelial Cells, Filtration, Humans, Lab-On-A-Chip Devices, Lymph Nodes, Lymphatic Metastasis, Lymphatic System, Neoplasm Metastasis, Neoplasms, Neoplastic Cells, Circulating, Prognosis, TNF-Related Apoptosis-Inducing Ligand
Added April 15, 2019
0 Communities
1 Members
0 Resources
15 MeSH Terms
Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry.
Yamazaki H, Suemizu H, Kazuki Y, Oofusa K, Kuribayashi S, Shimizu M, Ninomiya S, Horie T, Shibata N, Guengerich FP
(2016) Chem Res Toxicol 29: 1279-81
MeSH Terms: Animals, Cytochrome P-450 Enzyme System, Electrophoresis, Gel, Two-Dimensional, Hepatocytes, Humans, Mass Spectrometry, Mice, Protein Binding, Thalidomide
Added March 14, 2018
0 Communities
1 Members
0 Resources
9 MeSH Terms
Identification of a Novel Transcript and Regulatory Mechanism for Microsomal Triglyceride Transfer Protein.
Suzuki T, Brown JJ, Swift LL
(2016) PLoS One 11: e0147252
MeSH Terms: Alternative Splicing, Animals, CHO Cells, Carrier Proteins, Cricetulus, Electrophoresis, Polyacrylamide Gel, Female, HEK293 Cells, Humans, Mice, Protein Isoforms, RNA, Messenger, Rabbits, Reverse Transcriptase Polymerase Chain Reaction
Added February 22, 2016
0 Communities
1 Members
0 Resources
14 MeSH Terms
Medically Relevant Acinetobacter Species Require a Type II Secretion System and Specific Membrane-Associated Chaperones for the Export of Multiple Substrates and Full Virulence.
Harding CM, Kinsella RL, Palmer LD, Skaar EP, Feldman MF
(2016) PLoS Pathog 12: e1005391
MeSH Terms: Acinetobacter, Acinetobacter Infections, Animals, Electrophoresis, Gel, Two-Dimensional, Electrophoresis, Polyacrylamide Gel, Humans, Mice, Mice, Inbred C57BL, Molecular Chaperones, Type II Secretion Systems, Virulence
Added February 8, 2016
0 Communities
2 Members
0 Resources
11 MeSH Terms
Microsomal Triglyceride Transfer Protein (MTP) Associates with Cytosolic Lipid Droplets in 3T3-L1 Adipocytes.
Love JD, Suzuki T, Robinson DB, Harris CM, Johnson JE, Mohler PJ, Jerome WG, Swift LL
(2015) PLoS One 10: e0135598
MeSH Terms: 3T3-L1 Cells, Adipocytes, Animals, Carrier Proteins, Cell Differentiation, Cytosol, Electrophoresis, Polyacrylamide Gel, Immunohistochemistry, Lipid Droplets, Mice, Microscopy, Fluorescence, Reverse Transcriptase Polymerase Chain Reaction
Added September 30, 2015
0 Communities
2 Members
0 Resources
12 MeSH Terms
A conserved role of αA-crystallin in the development of the zebrafish embryonic lens.
Zou P, Wu SY, Koteiche HA, Mishra S, Levic DS, Knapik E, Chen W, Mchaourab HS
(2015) Exp Eye Res 138: 104-13
MeSH Terms: Animals, Animals, Genetically Modified, Blotting, Western, Electrophoresis, Polyacrylamide Gel, Embryo, Nonmammalian, Gene Expression Regulation, Developmental, Gene Knockout Techniques, Lens, Crystalline, Real-Time Polymerase Chain Reaction, Zebrafish, alpha-Crystallin A Chain
Added July 23, 2015
1 Communities
2 Members
0 Resources
11 MeSH Terms
Recessive osteogenesis imperfecta caused by missense mutations in SPARC.
Mendoza-Londono R, Fahiminiya S, Majewski J, Care4Rare Canada Consortium, Tétreault M, Nadaf J, Kannu P, Sochett E, Howard A, Stimec J, Dupuis L, Roschger P, Klaushofer K, Palomo T, Ouellet J, Al-Jallad H, Mort JS, Moffatt P, Boudko S, Bächinger HP, Rauch F
(2015) Am J Hum Genet 96: 979-85
MeSH Terms: Amino Acid Sequence, Base Sequence, Collagen Type I, Electrophoresis, Polyacrylamide Gel, Exome, Female, Genes, Recessive, Humans, Immunoblotting, Models, Molecular, Molecular Sequence Data, Mutagenesis, Site-Directed, Mutation, Missense, Osteogenesis Imperfecta, Osteonectin, Pedigree, Protein Conformation, Sequence Alignment, Sequence Analysis, DNA
Added November 2, 2017
0 Communities
1 Members
0 Resources
19 MeSH Terms
[Construction, expression, and identification of the gene of human anti-prostate specific membrane antigen single-chain antibody].
Su YS, Fu XL, Wang D, Wang QY, Liu N, Jia HB, Qin WJ, Wen WH, Wang H
(2014) Zhonghua Nan Ke Xue 20: 1063-7
MeSH Terms: Antigens, Surface, Cloning, Molecular, Electrophoresis, Polyacrylamide Gel, Escherichia coli, Glutamate Carboxypeptidase II, Humans, Male, Polymerase Chain Reaction, RNA, Small Interfering, Recombinant Fusion Proteins, Single-Chain Antibodies
Added January 20, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms