Induction of lateral lumens through disruption of a monoleucine-based basolateral-sorting motif in betacellulin.
Singh B, Bogatcheva G, Starchenko A, Sinnaeve J, Lapierre LA, Williams JA, Goldenring JR, Coffey RJ
(2015) J Cell Sci 128
: 3444-55MeSH Terms: Amino Acid Sequence, Animals, Betacellulin, Cell Polarity, Dogs, EGF Family of Proteins, ErbB Receptors, Fluorescent Antibody Technique, Madin Darby Canine Kidney Cells, Mutation, Protein Sorting Signals, Protein Structure, TertiaryAdded September 28, 2015
12 MeSH Terms
Endothelial cells control pancreatic cell fate at defined stages through EGFL7 signaling.
Kao DI, Lacko LA, Ding BS, Huang C, Phung K, Gu G, Rafii S, Stuhlmann H, Chen S
(2015) Stem Cell Reports 4
: 181-9MeSH Terms: Calcium-Binding Proteins, Cell Communication, Cell Differentiation, Cell Line, Cell Proliferation, Coculture Techniques, EGF Family of Proteins, Embryonic Stem Cells, Endothelial Cells, Endothelial Growth Factors, Gene Expression, Gene Expression Profiling, Gene Expression Regulation, Developmental, Homeodomain Proteins, Humans, Immunophenotyping, Pancreas, Phenotype, Signal Transduction, Stem Cell Niche, Trans-Activators, TranscriptomeAdded December 4, 2020
22 MeSH Terms
8 MeSH Terms
Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids.
Nagathihalli NS, Beesetty Y, Lee W, Washington MK, Chen X, Lockhart AC, Merchant NB
(2014) Cancer Res 74
: 2062-72MeSH Terms: ADAM Proteins, ADAM17 Protein, Amphiregulin, Bile Acids and Salts, Cyclin D1, Deoxycholic Acid, EGF Family of Proteins, ErbB Receptors, Gastrointestinal Neoplasms, Glycoproteins, HCT116 Cells, Humans, Intercellular Signaling Peptides and Proteins, Pancreas, Phosphorylation, Receptors, G-Protein-Coupled, STAT3 Transcription Factor, Transforming Growth Factor alpha, src-Family KinasesAdded February 14, 2014
19 MeSH Terms
Myofibroblast keratinocyte growth factor reduces tight junctional integrity and increases claudin-2 levels in polarized Caco-2 cells.
Kim TI, Poulin EJ, Blask E, Bukhalid R, Whitehead RH, Franklin JL, Coffey RJ
(2012) Growth Factors 30
: 320-32MeSH Terms: Amphiregulin, Caco-2 Cells, Cell Communication, Cell Line, Tumor, Cell Membrane Permeability, Cell Proliferation, Claudin-2, Culture Media, Conditioned, EGF Family of Proteins, Electric Impedance, ErbB Receptors, Fibroblast Growth Factor 7, Glycoproteins, Humans, Intercellular Signaling Peptides and Proteins, Intestinal Mucosa, Ligands, Myofibroblasts, Tight JunctionsAdded December 5, 2013
19 MeSH Terms
Identification of a novel mono-leucine basolateral sorting motif within the cytoplasmic domain of amphiregulin.
Gephart JD, Singh B, Higginbotham JN, Franklin JL, Gonzalez A, Fölsch H, Coffey RJ
(2011) Traffic 12
: 1793-804MeSH Terms: Amino Acid Motifs, Amino Acid Sequence, Amphiregulin, Animals, Cell Line, Cell Membrane, Cell Polarity, Cytoplasm, Dogs, EGF Family of Proteins, Epithelial Cells, ErbB Receptors, Glycoproteins, Humans, Intercellular Signaling Peptides and Proteins, LLC-PK1 Cells, Leucine, Membrane Proteins, Molecular Sequence Data, Protein Structure, Tertiary, Protein Transport, Receptors, Nerve Growth Factor, SwineAdded December 5, 2013
23 MeSH Terms
Sustained activation of the HER1-ERK1/2-RSK signaling pathway controls myoepithelial cell fate in human mammary tissue.
Pasic L, Eisinger-Mathason TS, Velayudhan BT, Moskaluk CA, Brenin DR, Macara IG, Lannigan DA
(2011) Genes Dev 25
: 1641-53MeSH Terms: Amphiregulin, Animals, Apoptosis, Bacterial Capsules, Cell Differentiation, Cell Proliferation, Cells, Cultured, EGF Family of Proteins, Epidermal Growth Factor, Epithelial Cells, ErbB Receptors, Glycoproteins, Humans, Intercellular Signaling Peptides and Proteins, Mammary Glands, Human, Mice, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Receptor, Fibroblast Growth Factor, Type 2, Ribosomal Protein S6 Kinases, 90-kDa, Signal TransductionAdded March 5, 2014
21 MeSH Terms
Amphiregulin exosomes increase cancer cell invasion.
Higginbotham JN, Demory Beckler M, Gephart JD, Franklin JL, Bogatcheva G, Kremers GJ, Piston DW, Ayers GD, McConnell RE, Tyska MJ, Coffey RJ
(2011) Curr Biol 21
: 779-86MeSH Terms: Amphiregulin, Animals, Cell Line, Tumor, Centrifugation, Dogs, EGF Family of Proteins, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, ErbB Receptors, Exosomes, Glycoproteins, Heparin-binding EGF-like Growth Factor, Humans, Immunoblotting, Intercellular Signaling Peptides and Proteins, Microscopy, Electron, Neoplasm Invasiveness, Signal Transduction, Transforming Growth Factor alphaAdded December 6, 2012
19 MeSH Terms
Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer.
Regales L, Gong Y, Shen R, de Stanchina E, Vivanco I, Goel A, Koutcher JA, Spassova M, Ouerfelli O, Mellinghoff IK, Zakowski MF, Politi KA, Pao W
(2009) J Clin Invest 119
: 3000-10MeSH Terms: Afatinib, Amphiregulin, Animals, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Cetuximab, Disease Models, Animal, Drug Resistance, Neoplasm, EGF Family of Proteins, Epidermal Growth Factor, Epiregulin, ErbB Receptors, Erlotinib Hydrochloride, Gene Expression Profiling, Glycoproteins, Humans, Intercellular Signaling Peptides and Proteins, Lung Neoplasms, Male, Mice, Mice, Nude, Mice, Transgenic, Mutation, Neoplasm Transplantation, Paclitaxel, Protein Kinase Inhibitors, Quinazolines, Transplantation, Heterologous, Tumor Cells, CulturedAdded March 24, 2014
30 MeSH Terms
Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia.
Nam KT, Lee HJ, Mok H, Romero-Gallo J, Crowe JE, Peek RM, Goldenring JR
(2009) Gastroenterology 136
: 1288-96MeSH Terms: Amphiregulin, Animals, Cell Proliferation, Disease Models, Animal, EGF Family of Proteins, Gastric Fundus, Gastric Mucosa, Genetic Predisposition to Disease, Glycoproteins, Intercellular Signaling Peptides and Proteins, Intestinal Mucosa, Intestines, Metaplasia, Mice, Mice, Inbred C57BL, Mice, Knockout, Mucin-2, Mucins, Muscle Proteins, Peptides, Stomach, Stomach Neoplasms, Transforming Growth Factor alpha, Trefoil Factor-2, Trefoil Factor-3, beta CateninAdded October 7, 2013
26 MeSH Terms