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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 21

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ERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer.
Miller TW, Balko JM, Fox EM, Ghazoui Z, Dunbier A, Anderson H, Dowsett M, Jiang A, Smith RA, Maira SM, Manning HC, González-Angulo AM, Mills GB, Higham C, Chanthaphaychith S, Kuba MG, Miller WR, Shyr Y, Arteaga CL
(2011) Cancer Discov 1: 338-51
MeSH Terms: Animals, Breast Neoplasms, Cell Line, Tumor, Cyclin-Dependent Kinase 4, Down-Regulation, Drug Resistance, Neoplasm, E2F Transcription Factors, Estrogen Receptor Modulators, Estrogen Receptor alpha, Estrogens, Female, Gene Expression, Humans, Mice, Mice, Nude, Phosphatidylinositol 3-Kinases, Transcription, Genetic
Added March 5, 2014
0 Communities
4 Members
0 Resources
17 MeSH Terms
E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivo.
Sun H, Wang Y, Chinnam M, Zhang X, Hayward SW, Foster BA, Nikitin AY, Wills M, Goodrich DW
(2011) Proc Natl Acad Sci U S A 108: 704-9
MeSH Terms: Alleles, Animals, DNA Mutational Analysis, Disease Models, Animal, Disease Progression, E2F Transcription Factors, Genes, Retinoblastoma, Heterozygote, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Prostatic Neoplasms, Retinoblastoma Protein
Added May 27, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
An E2F binding-deficient Rb1 protein partially rescues developmental defects associated with Rb1 nullizygosity.
Sun H, Chang Y, Schweers B, Dyer MA, Zhang X, Hayward SW, Goodrich DW
(2006) Mol Cell Biol 26: 1527-37
MeSH Terms: Alleles, Amino Acid Substitution, Animals, Base Sequence, Cell Cycle, Congenital Abnormalities, DNA, E2F Transcription Factors, Female, Fetal Development, Homozygote, Male, Mice, Mice, Knockout, Mice, Mutant Strains, Mutagenesis, Site-Directed, Pregnancy, Recombinant Proteins, Retina, Retinoblastoma Protein
Added December 10, 2013
0 Communities
1 Members
0 Resources
20 MeSH Terms
Disruption of Rb/E2F pathway results in increased cyclooxygenase-2 expression and activity in prostate epithelial cells.
Davis JN, McCabe MT, Hayward SW, Park JM, Day ML
(2005) Cancer Res 65: 3633-42
MeSH Terms: Animals, Cell Cycle Proteins, Cell Line, Cyclooxygenase 2, DNA-Binding Proteins, Dinoprostone, E2F Transcription Factors, E2F1 Transcription Factor, Enzyme Activation, Epithelial Cells, Gene Expression Regulation, Enzymologic, Genes, myc, Male, Mice, Promoter Regions, Genetic, Prostaglandin-Endoperoxide Synthases, Prostate, RNA, Messenger, Retinoblastoma Protein, Transcription Factors, Transcriptional Activation, Up-Regulation
Added December 10, 2013
0 Communities
1 Members
0 Resources
22 MeSH Terms
siRNA-mediated gene silencing: a global genome view.
Semizarov D, Kroeger P, Fesik S
(2004) Nucleic Acids Res 32: 3836-45
MeSH Terms: Binding Sites, Cell Cycle Proteins, Cell Line, Tumor, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Cyclin-Dependent Kinases, DNA-Binding Proteins, E2F Transcription Factors, Gene Expression Profiling, Genomics, Humans, Oligonucleotide Array Sequence Analysis, Proto-Oncogene Proteins, RNA Interference, RNA, Small Interfering, Response Elements, Retinoblastoma Protein, Signal Transduction, Software, Transcription Factors, Transcriptional Activation, Transfection
Added March 5, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1.
Eischen CM, Packham G, Nip J, Fee BE, Hiebert SW, Zambetti GP, Cleveland JL
(2001) Oncogene 20: 6983-93
MeSH Terms: Animals, Apoptosis, Cell Cycle Proteins, Cell Line, Transformed, Cell Transformation, Neoplastic, DNA, DNA-Binding Proteins, E2F Transcription Factors, E2F1 Transcription Factor, Gene Expression Regulation, Genes, bcl-2, Genes, myc, Genes, p53, Interleukin-3, Mice, Mutation, Myeloid Cells, Protein Binding, Protein Conformation, Proto-Oncogene Proteins c-bcl-2, Proto-Oncogene Proteins c-myc, Recombinant Fusion Proteins, Temperature, Transcription Factors, Transfection, Tumor Suppressor Protein p14ARF, Tumor Suppressor Protein p53, bcl-X Protein
Added June 10, 2010
1 Communities
2 Members
0 Resources
28 MeSH Terms
Topoisomerase IIalpha mediates E2F-1-induced chemosensitivity and is a target for p53-mediated transcriptional repression.
Nip J, Hiebert SW
(2000) Cell Biochem Biophys 33: 199-207
MeSH Terms: Antigens, Neoplasm, Apoptosis, Carrier Proteins, Cell Cycle, Cell Cycle Proteins, Cell Line, Cell Survival, DNA Topoisomerases, Type II, DNA-Binding Proteins, Diketopiperazines, E2F Transcription Factors, E2F1 Transcription Factor, Enzyme Inhibitors, Humans, Interleukin-3, Isoenzymes, Piperazines, Retinoblastoma-Binding Protein 1, Sirolimus, Topoisomerase II Inhibitors, Transcription Factor DP1, Transcription Factors, Transcription, Genetic, Tumor Suppressor Protein p53
Added June 10, 2010
1 Communities
1 Members
0 Resources
24 MeSH Terms
E2F-1 induces the stabilization of p53 but blocks p53-mediated transactivation.
Nip J, Strom DK, Eischen CM, Cleveland JL, Zambetti GP, Hiebert SW
(2001) Oncogene 20: 910-20
MeSH Terms: Animals, Binding Sites, Carrier Proteins, Cell Cycle, Cell Cycle Proteins, Cells, Cultured, DNA-Binding Proteins, E2F Transcription Factors, E2F1 Transcription Factor, Mice, Protein Binding, Protein Processing, Post-Translational, Proteins, Retinoblastoma-Binding Protein 1, Transcription Factor DP1, Transcription Factors, Transcriptional Activation, Tumor Suppressor Protein p14ARF, Tumor Suppressor Protein p53
Added June 10, 2010
1 Communities
2 Members
0 Resources
19 MeSH Terms
Oncogenes induce and activate endogenous p73 protein.
Zaika A, Irwin M, Sansome C, Moll UM
(2001) J Biol Chem 276: 11310-6
MeSH Terms: Adenovirus E1A Proteins, Carrier Proteins, Cell Cycle Proteins, DNA-Binding Proteins, E2F Transcription Factors, E2F1 Transcription Factor, Gene Expression Regulation, Neoplastic, Genes, Tumor Suppressor, Genes, myc, Humans, Nuclear Proteins, Oncogenes, Retinoblastoma-Binding Protein 1, Transcription Factor DP1, Transcription Factors, Tumor Cells, Cultured, Tumor Protein p73, Tumor Suppressor Proteins
Added March 5, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
c-myc-enhanced S phase entry in keratinocytes is associated with positive and negative effects on cyclin-dependent kinases.
Alexandrow MG, Moses HL
(1998) J Cell Biochem 70: 528-42
MeSH Terms: Animals, Carrier Proteins, Cell Cycle Proteins, Cells, Cultured, Cyclin-Dependent Kinase Inhibitor p27, Cyclin-Dependent Kinases, DNA-Binding Proteins, E2F Transcription Factors, E2F1 Transcription Factor, Epidermal Growth Factor, G1 Phase, Gene Expression Regulation, Keratinocytes, Mice, Mice, Inbred BALB C, Microtubule-Associated Proteins, Protamine Kinase, Proto-Oncogene Proteins c-myc, Rats, Retinoblastoma-Binding Protein 1, S Phase, Thymidine, Transcription Factor DP1, Transcription Factors, Tumor Suppressor Proteins
Added February 17, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms