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Results: 1 to 10 of 112

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The antifungal drug isavuconazole inhibits the replication of human cytomegalovirus (HCMV) and acts synergistically with anti-HCMV drugs.
Mercorelli B, Celegato M, Luganini A, Gribaudo G, Lepesheva GI, Loregian A
(2021) Antiviral Res 189: 105062
MeSH Terms: Antifungal Agents, Antiviral Agents, Cell Line, Cytomegalovirus, Cytomegalovirus Infections, Drug Repositioning, Drug Resistance, Viral, Drug Synergism, Drug Therapy, Combination, Humans, Nitriles, Pyridines, Sterol 14-Demethylase, Triazoles, Virus Replication
Added July 2, 2021
0 Communities
1 Members
0 Resources
15 MeSH Terms
Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation.
Healey DCC, Cephus JY, Barone SM, Chowdhury NU, Dahunsi DO, Madden MZ, Ye X, Yu X, Olszewski K, Young K, Gerriets VA, Siska PJ, Dworski R, Hemler J, Locasale JW, Poyurovsky MV, Peebles RS, Irish JM, Newcomb DC, Rathmell JC
(2021) J Immunol 206: 1127-1139
MeSH Terms: Adult, Alternaria, Animals, Asthma, Biomarkers, Blood Glucose, Bronchoalveolar Lavage Fluid, Case-Control Studies, Cells, Cultured, Dexamethasone, Disease Models, Animal, Drug Synergism, Female, Glucose Transporter Type 1, Glutaminase, Glutamine, Healthy Volunteers, Humans, Immunosuppressive Agents, Lung, Male, Mice, Middle Aged, Primary Cell Culture, Pyroglyphidae, Th17 Cells, Th2 Cells, Young Adult
Added March 26, 2021
3 Communities
1 Members
0 Resources
28 MeSH Terms
Charting the Fragmented Landscape of Drug Synergy.
Meyer CT, Wooten DJ, Lopez CF, Quaranta V
(2020) Trends Pharmacol Sci 41: 266-280
MeSH Terms: Drug Synergism, Drug Therapy, Combination, Humans
Added March 30, 2020
0 Communities
1 Members
0 Resources
3 MeSH Terms
Quantifying Drug Combination Synergy along Potency and Efficacy Axes.
Meyer CT, Wooten DJ, Paudel BB, Bauer J, Hardeman KN, Westover D, Lovly CM, Harris LA, Tyson DR, Quaranta V
(2019) Cell Syst 8: 97-108.e16
MeSH Terms: Drug Combinations, Drug Synergism, Humans, Melanoma
Added March 23, 2019
0 Communities
3 Members
0 Resources
4 MeSH Terms
Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi.
Guedes-da-Silva FH, Batista DDGJ, Da Silva CF, Pavão BP, Batista MM, Moreira OC, Souza LRQ, Britto C, Rachakonda G, Villalta F, Lepesheva GI, Soeiro MNC
(2019) ACS Infect Dis 5: 365-371
MeSH Terms: 14-alpha Demethylase Inhibitors, Animals, Chagas Disease, Disease Models, Animal, Drug Synergism, Drug Therapy, Combination, Humans, Male, Mice, Nitroimidazoles, Protozoan Proteins, Sterol 14-Demethylase, Trypanocidal Agents, Trypanosoma cruzi
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
The BET inhibitor INCB054329 reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer.
Wilson AJ, Stubbs M, Liu P, Ruggeri B, Khabele D
(2018) Gynecol Oncol 149: 575-584
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, BRCA1 Protein, Carcinoma, Ovarian Epithelial, Cell Cycle Proteins, Cell Line, Tumor, Down-Regulation, Drug Synergism, Female, Homologous Recombination, Humans, Indoles, Mice, Mice, Inbred NOD, Mice, Nude, Mice, SCID, Neoplasms, Glandular and Epithelial, Nuclear Proteins, Organic Chemicals, Ovarian Neoplasms, Phthalazines, Piperazines, Poly(ADP-ribose) Polymerase Inhibitors, Transcription Factors, Xenograft Model Antitumor Assays
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
ML327 induces apoptosis and sensitizes Ewing sarcoma cells to TNF-related apoptosis-inducing ligand.
Rellinger EJ, Padmanabhan C, Qiao J, Appert A, Waterson AG, Lindsley CW, Beauchamp RD, Chung DH
(2017) Biochem Biophys Res Commun 491: 463-468
MeSH Terms: Antigens, CD, Antineoplastic Agents, Apoptosis, Cadherins, Caspase 3, Cell Cycle, Cell Line, Tumor, Drug Synergism, Epithelial-Mesenchymal Transition, Gene Expression Regulation, Humans, Isoxazoles, Mesenchymal Stem Cells, Niacinamide, Poly(ADP-ribose) Polymerases, Sarcoma, Ewing, Signal Transduction, Small Molecule Libraries, TNF-Related Apoptosis-Inducing Ligand, Vimentin
Added March 14, 2018
0 Communities
1 Members
0 Resources
20 MeSH Terms
Panobinostat sensitizes cyclin E high, homologous recombination-proficient ovarian cancer to olaparib.
Wilson AJ, Sarfo-Kantanka K, Barrack T, Steck A, Saskowski J, Crispens MA, Khabele D
(2016) Gynecol Oncol 143: 143-151
MeSH Terms: Antineoplastic Agents, Cyclin E, DNA Repair, Drug Synergism, Female, Homologous Recombination, Humans, Hydroxamic Acids, Indoles, Oncogene Proteins, Ovarian Neoplasms, Panobinostat, Phthalazines, Piperazines
Added March 4, 2019
0 Communities
2 Members
0 Resources
MeSH Terms
Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition.
Hubers SA, Brown NJ
(2016) Circulation 133: 1115-24
MeSH Terms: Abnormalities, Drug-Induced, Aminobutyrates, Angioedema, Angiotensin Receptor Antagonists, Biphenyl Compounds, Bradykinin, Contraindications, Drug Combinations, Drug Costs, Drug Synergism, Enalapril, Enzyme Inhibitors, Female, Follow-Up Studies, Heart Failure, Humans, Hyperkalemia, Hypertension, Kidney, Multicenter Studies as Topic, Natriuretic Peptides, Neprilysin, Pregnancy, Prodrugs, Prospective Studies, Pyridines, Randomized Controlled Trials as Topic, Stroke Volume, Tetrazoles, Thiazepines, Valsartan
Added April 6, 2017
0 Communities
1 Members
0 Resources
31 MeSH Terms
EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer.
Amato KR, Wang S, Tan L, Hastings AK, Song W, Lovly CM, Meador CB, Ye F, Lu P, Balko JM, Colvin DC, Cates JM, Pao W, Gray NS, Chen J
(2016) Cancer Res 76: 305-18
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Benzamides, Cell Line, Tumor, Cell Proliferation, Drug Resistance, Neoplasm, Drug Synergism, ErbB Receptors, Erlotinib Hydrochloride, Humans, Lung Neoplasms, Mice, Mice, Nude, Niacinamide, Protein Kinase Inhibitors, Receptor, EphA2, Signal Transduction, Xenograft Model Antitumor Assays
Added January 26, 2016
0 Communities
3 Members
0 Resources
19 MeSH Terms