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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 39

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Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae.
Friggeri L, Hargrove TY, Rachakonda G, Blobaum AL, Fisher P, de Oliveira GM, da Silva CF, Soeiro MNC, Nes WD, Lindsley CW, Villalta F, Guengerich FP, Lepesheva GI
(2018) J Med Chem 61: 10910-10921
MeSH Terms: 14-alpha Demethylase Inhibitors, Antiprotozoal Agents, Chagas Disease, Drug Design, Drug Stability, Humans, Microsomes, Models, Molecular, Protein Conformation, Sterol 14-Demethylase, Trypanosoma cruzi
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Excipients for the lyoprotection of MAPKAP kinase 2 inhibitory peptide nano-polyplexes.
Mukalel AJ, Evans BC, Kilchrist KV, Dailing EA, Burdette B, Cheung-Flynn J, Brophy CM, Duvall CL
(2018) J Control Release 282: 110-119
MeSH Terms: Cell Line, Drug Stability, Enzyme Inhibitors, Excipients, Freeze Drying, Humans, Intracellular Signaling Peptides and Proteins, Nanoparticles, Peptides, Protein Serine-Threonine Kinases, Sucrose, Trehalose, Trisaccharides
Added May 22, 2018
0 Communities
2 Members
0 Resources
13 MeSH Terms
Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs.
Garcia-Barrantes PM, Cho HP, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW
(2016) Bioorg Med Chem Lett 26: 1869-72
MeSH Terms: Allosteric Regulation, Central Nervous System, Coumarins, Dose-Response Relationship, Drug, Drug Discovery, Drug Stability, Furans, Humans, Isoindoles, Molecular Structure, Phthalimides, Receptors, Metabotropic Glutamate, Structure-Activity Relationship, Substrate Specificity
Added April 6, 2017
0 Communities
2 Members
0 Resources
14 MeSH Terms
Dual drug delivery of tamoxifen and quercetin: Regulated metabolism for anticancer treatment with nanosponges.
Lockhart JN, Stevens DM, Beezer DB, Kravitz A, Harth E
(2015) J Control Release 220: 751-7
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Biological Availability, Biotransformation, Breast Neoplasms, Cell Line, Tumor, Cell Survival, Chemistry, Pharmaceutical, Cross-Linking Reagents, Cytochrome P-450 CYP3A, Delayed-Action Preparations, Dose-Response Relationship, Drug, Drug Carriers, Drug Stability, Female, Gastric Juice, Glucuronosyltransferase, Intestinal Secretions, Kinetics, Mice, Nanomedicine, Nanoparticles, Particle Size, Polyesters, Quercetin, Solubility, Tamoxifen
Added February 15, 2016
0 Communities
1 Members
0 Resources
27 MeSH Terms
Stable RAGE-heparan sulfate complexes are essential for signal transduction.
Xu D, Young JH, Krahn JM, Song D, Corbett KD, Chazin WJ, Pedersen LC, Esko JD
(2013) ACS Chem Biol 8: 1611-20
MeSH Terms: Coordination Complexes, Dimerization, Drug Stability, Endothelial Cells, Heparitin Sulfate, Humans, Models, Molecular, Receptor for Advanced Glycation End Products, Signal Transduction, X-Ray Diffraction
Added March 7, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage.
Gentry AC, Pitts SL, Jablonsky MJ, Bailly C, Graves DE, Osheroff N
(2011) Biochemistry 50: 3240-9
MeSH Terms: Antigens, Neoplasm, Antineoplastic Agents, DNA, DNA Cleavage, DNA Topoisomerases, Type II, DNA-Binding Proteins, Drug Stability, Etoposide, Humans, Podophyllotoxin, Protein Binding, Spermine, Structure-Activity Relationship
Added March 7, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide.
Xia J, Noronha A, Toudjarska I, Li F, Akinc A, Braich R, Frank-Kamenetsky M, Rajeev KG, Egli M, Manoharan M
(2006) ACS Chem Biol 1: 176-83
MeSH Terms: Base Pairing, Base Sequence, Drug Stability, Gene Silencing, Hydrogen Bonding, Models, Molecular, Nucleic Acid Conformation, RNA, Small Interfering, Ribonucleotides
Added March 5, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Redox instability induced by 4-hydroxy-2-nonenal in porcine and bovine myoglobins at pH 5.6 and 4 degrees C.
Suman SP, Faustman C, Stamer SL, Liebler DC
(2006) J Agric Food Chem 54: 3402-8
MeSH Terms: Aldehydes, Animals, Cattle, Drug Stability, Hydrogen-Ion Concentration, Myoglobin, Oxidation-Reduction, Swine
Added March 20, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Site specific synthesis and polymerase bypass of oligonucleotides containing a 6-hydroxy-3,5,6,7-tetrahydro-9H-imidazo[1,2-a]purin-9-one base, an intermediate in the formation of 1,N2-etheno-2'-deoxyguanosine.
Goodenough AK, Kozekov ID, Zang H, Choi JY, Guengerich FP, Harris TM, Rizzo CJ
(2005) Chem Res Toxicol 18: 1701-14
MeSH Terms: Chromatography, High Pressure Liquid, Deoxyguanosine, Drug Stability, Oligonucleotides, Temperature
Added March 5, 2014
0 Communities
2 Members
0 Resources
5 MeSH Terms
Sodium butyrate inhibits cell growth and stimulates p21WAF1/CIP1 protein in human colonic adenocarcinoma cells independently of p53 status.
Kobayashi H, Tan EM, Fleming SE
(2003) Nutr Cancer 46: 202-11
MeSH Terms: Adenocarcinoma, Butyrates, Cell Cycle, Cell Division, Chromatin, Colonic Neoplasms, Cyclin-Dependent Kinase Inhibitor p21, Cyclins, Drug Stability, Humans, Mutation, Promoter Regions, Genetic, RNA, Messenger, Transcription, Genetic, Transfection, Tumor Cells, Cultured, Tumor Suppressor Protein p53
Added August 21, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms