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Results: 1 to 10 of 446

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The antifungal drug isavuconazole inhibits the replication of human cytomegalovirus (HCMV) and acts synergistically with anti-HCMV drugs.
Mercorelli B, Celegato M, Luganini A, Gribaudo G, Lepesheva GI, Loregian A
(2021) Antiviral Res 189: 105062
MeSH Terms: Antifungal Agents, Antiviral Agents, Cell Line, Cytomegalovirus, Cytomegalovirus Infections, Drug Repositioning, Drug Resistance, Viral, Drug Synergism, Drug Therapy, Combination, Humans, Nitriles, Pyridines, Sterol 14-Demethylase, Triazoles, Virus Replication
Added July 2, 2021
0 Communities
1 Members
0 Resources
15 MeSH Terms
Helicobacter pylori Antimicrobial Resistance and Gene Variants in High- and Low-Gastric-Cancer-Risk Populations.
Mannion A, Dzink-Fox J, Shen Z, Piazuelo MB, Wilson KT, Correa P, Peek RM, Camargo MC, Fox JG
(2021) J Clin Microbiol 59:
MeSH Terms: Anti-Bacterial Agents, Clarithromycin, Colombia, Drug Resistance, Bacterial, Helicobacter Infections, Helicobacter pylori, Humans, Metronidazole, Microbial Sensitivity Tests, Phylogeny, RNA, Ribosomal, 16S, RNA, Ribosomal, 23S, South America, Stomach Neoplasms
Added March 17, 2021
0 Communities
1 Members
0 Resources
14 MeSH Terms
An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease.
Brubaker DK, Kumar MP, Chiswick EL, Gregg C, Starchenko A, Vega PN, Southard-Smith AN, Simmons AJ, Scoville EA, Coburn LA, Wilson KT, Lau KS, Lauffenburger DA
(2020) Sci Signal 13:
MeSH Terms: Animals, Cells, Cultured, Disease Models, Animal, Drug Resistance, Gastrointestinal Agents, Gene Expression Profiling, Humans, Inflammatory Bowel Diseases, Infliximab, Integrin alpha1, Integrins, Male, Mice, Proteomics, RNA-Seq, Signal Transduction, Single-Cell Analysis, Species Specificity, Translational Medical Research
Added August 6, 2020
0 Communities
1 Members
0 Resources
19 MeSH Terms
Vulnerability of drug-resistant EML4-ALK rearranged lung cancer to transcriptional inhibition.
Paliouras AR, Buzzetti M, Shi L, Donaldson IJ, Magee P, Sahoo S, Leong HS, Fassan M, Carter M, Di Leva G, Krebs MG, Blackhall F, Lovly CM, Garofalo M
(2020) EMBO Mol Med 12: e11099
MeSH Terms: Animals, Carcinoma, Non-Small-Cell Lung, Drug Resistance, Neoplasm, Female, Humans, Lung Neoplasms, Mice, Oncogene Proteins, Fusion, Protein Kinase Inhibitors, Transcription, Genetic
Added September 10, 2020
0 Communities
1 Members
0 Resources
10 MeSH Terms
miR-302a Inhibits Metastasis and Cetuximab Resistance in Colorectal Cancer by Targeting NFIB and CD44.
Sun L, Fang Y, Wang X, Han Y, Du F, Li C, Hu H, Liu H, Liu Q, Wang J, Liang J, Chen P, Yang H, Nie Y, Wu K, Fan D, Coffey RJ, Lu Y, Zhao X, Wang X
(2019) Theranostics 9: 8409-8425
MeSH Terms: Caco-2 Cells, Cetuximab, Colorectal Neoplasms, Drug Resistance, Neoplasm, Gene Expression Regulation, Neoplastic, HCT116 Cells, Humans, Hyaluronan Receptors, In Vitro Techniques, MicroRNAs, NFI Transcription Factors, Neoplasm Metastasis, Signal Transduction
Added March 3, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers.
Wooten DJ, Groves SM, Tyson DR, Liu Q, Lim JS, Albert R, Lopez CF, Sage J, Quaranta V
(2019) PLoS Comput Biol 15: e1007343
MeSH Terms: Algorithms, Animals, Basic Helix-Loop-Helix Transcription Factors, Bayes Theorem, Cell Line, Tumor, Cluster Analysis, Databases, Genetic, Drug Resistance, Neoplasm, Gene Expression, Gene Expression Regulation, Neoplastic, Gene Ontology, Gene Regulatory Networks, Humans, Mice, Models, Theoretical, Small Cell Lung Carcinoma, Systems Analysis, Transcription Factors
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Arachidonic Acid Kills Staphylococcus aureus through a Lipid Peroxidation Mechanism.
Beavers WN, Monteith AJ, Amarnath V, Mernaugh RL, Roberts LJ, Chazin WJ, Davies SS, Skaar EP
(2019) mBio 10:
MeSH Terms: Animals, Anti-Bacterial Agents, Arachidonic Acid, Brain, Dose-Response Relationship, Drug, Drug Resistance, Bacterial, Female, Kidney, Lipid Peroxidation, Lipids, Mice, Mice, Inbred BALB C, Microbial Sensitivity Tests, Mutation, Neutrophils, Oxidative Stress, Reactive Oxygen Species, Spleen, Staphylococcal Infections, Staphylococcus aureus, Teichoic Acids
Added March 11, 2020
0 Communities
1 Members
0 Resources
21 MeSH Terms
Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group.
Irvin MR, Sitlani CM, Floyd JS, Psaty BM, Bis JC, Wiggins KL, Whitsel EA, Sturmer T, Stewart J, Raffield L, Sun F, Liu CT, Xu H, Cupples AL, Tanner RM, Rossing P, Smith A, Zilhão NR, Launer LJ, Noordam R, Rotter JI, Yao J, Li X, Guo X, Limdi N, Sundaresan A, Lange L, Correa A, Stott DJ, Ford I, Jukema JW, Gudnason V, Mook-Kanamori DO, Trompet S, Palmas W, Warren HR, Hellwege JN, Giri A, O'donnell C, Hung AM, Edwards TL, Ahluwalia TS, Arnett DK, Avery CL
(2019) Am J Hypertens 32: 1146-1153
MeSH Terms: African Americans, Aged, Antihypertensive Agents, Blood Pressure, Case-Control Studies, DNA (Cytosine-5-)-Methyltransferases, DNA-Binding Proteins, Drug Resistance, Dystrophin-Associated Proteins, Europe, European Continental Ancestry Group, Female, Genetic Loci, Genome-Wide Association Study, Humans, Hypertension, Male, Middle Aged, Myosin Heavy Chains, Myosin Type V, Neuropeptides, Pharmacogenetics, Pharmacogenomic Variants, Polymorphism, Single Nucleotide, Risk Assessment, Risk Factors, Transcription Factors, United States
Added March 3, 2020
0 Communities
1 Members
0 Resources
28 MeSH Terms
Monitoring Therapeutic Response and Resistance: Analysis of Circulating Tumor DNA in Patients With ALK+ Lung Cancer.
Horn L, Whisenant JG, Wakelee H, Reckamp KL, Qiao H, Leal TA, Du L, Hernandez J, Huang V, Blumenschein GR, Waqar SN, Patel SP, Nieva J, Oxnard GR, Sanborn RE, Shaffer T, Garg K, Holzhausen A, Harrow K, Liang C, Lim LP, Li M, Lovly CM
(2019) J Thorac Oncol 14: 1901-1911
MeSH Terms: Adult, Aged, Aged, 80 and over, Anaplastic Lymphoma Kinase, Carcinoma, Non-Small-Cell Lung, Circulating Tumor DNA, Drug Resistance, Neoplasm, Female, Humans, Lung Neoplasms, Male, Middle Aged, Mutation, Oncogene Proteins, Fusion, Piperazines, Prognosis, Protein Kinase Inhibitors, Pyridazines
Added March 18, 2020
0 Communities
1 Members
0 Resources
18 MeSH Terms
Bcl2-Expressing Quiescent Type B Neural Stem Cells in the Ventricular-Subventricular Zone Are Resistant to Concurrent Temozolomide/X-Irradiation.
Cameron BD, Traver G, Roland JT, Brockman AA, Dean D, Johnson L, Boyd K, Ihrie RA, Freeman ML
(2019) Stem Cells 37: 1629-1639
MeSH Terms: Animals, Antineoplastic Agents, Alkylating, Apoptosis, Chemoradiotherapy, DNA Breaks, Double-Stranded, DNA Repair, Disease Models, Animal, Drug Resistance, Female, Glioblastoma, Lateral Ventricles, Male, Mice, Mice, Inbred C57BL, Neural Stem Cells, Neurogenesis, Proto-Oncogene Proteins c-bcl-2, Temozolomide, X-Ray Therapy
Added March 3, 2020
0 Communities
2 Members
0 Resources
19 MeSH Terms