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Results: 1 to 10 of 14

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The antifungal drug isavuconazole inhibits the replication of human cytomegalovirus (HCMV) and acts synergistically with anti-HCMV drugs.
Mercorelli B, Celegato M, Luganini A, Gribaudo G, Lepesheva GI, Loregian A
(2021) Antiviral Res 189: 105062
MeSH Terms: Antifungal Agents, Antiviral Agents, Cell Line, Cytomegalovirus, Cytomegalovirus Infections, Drug Repositioning, Drug Resistance, Viral, Drug Synergism, Drug Therapy, Combination, Humans, Nitriles, Pyridines, Sterol 14-Demethylase, Triazoles, Virus Replication
Added July 2, 2021
0 Communities
1 Members
0 Resources
15 MeSH Terms
A Coordinated Attack: Rett Syndrome Therapeutic Development.
Gogliotti RG, Niswender CM
(2019) Trends Pharmacol Sci 40: 233-236
MeSH Terms: Animals, Drug Discovery, Drug Evaluation, Preclinical, Drug Repositioning, Female, Humans, Methyl-CpG-Binding Protein 2, Mutation, Research Design, Rett Syndrome
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical models.
Lu T, Chen C, Wang A, Jiang Z, Qi Z, Hu Z, Hu C, Liu F, Wang W, Wu H, Wang B, Wang L, Qi S, Wu J, Wang W, Tang J, Yan H, Bai M, Liu Q, Liu J
(2019) Cancer Lett 447: 105-114
MeSH Terms: Anilides, Antineoplastic Agents, Cell Line, Tumor, Drug Repositioning, Drug Resistance, Neoplasm, Gastrointestinal Stromal Tumors, Humans, Imatinib Mesylate, Mutation, Proto-Oncogene Proteins c-kit, Pyridines
Added April 2, 2019
0 Communities
1 Members
0 Resources
11 MeSH Terms
Advocating for mutually beneficial access to shelved compounds.
Pulley JM, Jerome RN, Shirey-Rice JK, Zaleski NM, Naylor HM, Pruijssers AJ, Jackson JC, Bernard GR, Holroyd KJ
(2018) Future Med Chem 10: 1395-1398
MeSH Terms: Antidiuretic Hormone Receptor Antagonists, Anxiety Disorders, Depressive Disorder, Major, Drug Industry, Drug Repositioning, Humans, Indoles, Pyrrolidines, Receptors, Vasopressin
Added March 26, 2019
0 Communities
2 Members
0 Resources
MeSH Terms
Calcium channel blockers as drug repurposing candidates for gestational diabetes: Mining large scale genomic and electronic health records data to repurpose medications.
Goldstein JA, Bastarache LA, Denny JC, Roden DM, Pulley JM, Aronoff DM
(2018) Pharmacol Res 130: 44-51
MeSH Terms: Adolescent, Adult, Calcium Channel Blockers, Data Mining, Diabetes, Gestational, Drug Repositioning, Electronic Health Records, Female, Genomics, Humans, Middle Aged, Polymorphism, Single Nucleotide, Pregnancy, Young Adult
Added March 14, 2018
0 Communities
2 Members
0 Resources
14 MeSH Terms
When Enough Is Enough: Decision Criteria for Moving a Known Drug into Clinical Testing for a New Indication in the Absence of Preclinical Efficacy Data.
Pulley JM, Jerome RN, Zaleski NM, Shirey-Rice JK, Pruijssers AJ, Lavieri RR, Chettiar SN, Naylor HM, Aronoff DM, Edwards DA, Niswender CM, Dugan LL, Crofford LJ, Bernard GR, Holroyd KJ
(2017) Assay Drug Dev Technol 15: 354-361
MeSH Terms: Animals, Clinical Trials as Topic, Decision Making, Drug Evaluation, Preclinical, Drug Repositioning, Humans, Models, Animal
Added March 26, 2019
0 Communities
4 Members
0 Resources
MeSH Terms
The Influence of Big (Clinical) Data and Genomics on Precision Medicine and Drug Development.
Denny JC, Van Driest SL, Wei WQ, Roden DM
(2018) Clin Pharmacol Ther 103: 409-418
MeSH Terms: Big Data, Drug Repositioning, Electronic Health Records, Humans, Pharmacogenetics, Pharmacology, Clinical, Precision Medicine, Randomized Controlled Trials as Topic
Added March 14, 2018
0 Communities
2 Members
0 Resources
8 MeSH Terms
Genome-wide and Phenome-wide Approaches to Understand Variable Drug Actions in Electronic Health Records.
Robinson JR, Denny JC, Roden DM, Van Driest SL
(2018) Clin Transl Sci 11: 112-122
MeSH Terms: Biological Variation, Population, Computational Biology, Drug Discovery, Drug Repositioning, Drug-Related Side Effects and Adverse Reactions, Electronic Health Records, Genome, Genome-Wide Association Study, Humans, Molecular Targeted Therapy, Pharmacogenetics, Phenotype, Polymorphism, Single Nucleotide, Treatment Outcome
Added March 14, 2018
0 Communities
3 Members
0 Resources
14 MeSH Terms
Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics.
Pulley JM, Shirey-Rice JK, Lavieri RR, Jerome RN, Zaleski NM, Aronoff DM, Bastarache L, Niu X, Holroyd KJ, Roden DM, Skaar EP, Niswender CM, Marnett LJ, Lindsley CW, Ekstrom LB, Bentley AR, Bernard GR, Hong CC, Denny JC
(2017) Assay Drug Dev Technol 15: 113-119
MeSH Terms: Databases, Genetic, Drug Design, Drug Repositioning, Genetic Predisposition to Disease, Genome, Human, Humans, Pharmacogenomic Testing, Precision Medicine
Added April 8, 2017
0 Communities
8 Members
0 Resources
8 MeSH Terms
Repurposing the Nonsteroidal Anti-inflammatory Drug Diflunisal as an Osteoprotective, Antivirulence Therapy for Staphylococcus aureus Osteomyelitis.
Hendrix AS, Spoonmore TJ, Wilde AD, Putnam NE, Hammer ND, Snyder DJ, Guelcher SA, Skaar EP, Cassat JE
(2016) Antimicrob Agents Chemother 60: 5322-30
MeSH Terms: Animals, Anti-Bacterial Agents, Anti-Inflammatory Agents, Non-Steroidal, Bacterial Proteins, Bone Density Conservation Agents, Cell Survival, Delayed-Action Preparations, Diflunisal, Drug Repositioning, Female, Gene Expression, Humans, Mice, Mice, Inbred C57BL, Osteoblasts, Osteomyelitis, Primary Cell Culture, Staphylococcal Infections, Staphylococcus aureus, Trans-Activators, Treatment Outcome
Added April 8, 2017
0 Communities
3 Members
0 Resources
21 MeSH Terms