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Results: 1 to 10 of 20

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Electrophilic adduction of ubiquitin activating enzyme E1 by N,N-diethyldithiocarbamate inhibits ubiquitin activation and is accompanied by striatal injury in the rat.
Viquez OM, Caito SW, McDonald WH, Friedman DB, Valentine WM
(2012) Chem Res Toxicol 25: 2310-21
MeSH Terms: Animals, Corpus Striatum, Ditiocarb, Enzyme Activation, Enzyme Inhibitors, Humans, Male, Models, Molecular, Rats, Rats, Sprague-Dawley, Structure-Activity Relationship, Ubiquitin-Activating Enzymes
Added March 20, 2014
0 Communities
2 Members
0 Resources
12 MeSH Terms
Peripheral nerve and brain differ in their capacity to resolve N,N-diethyldithiocarbamate-mediated elevations in copper and oxidative injury.
Valentine HL, Viquez OM, Valentine WM
(2010) Toxicology 274: 10-7
MeSH Terms: Animals, Blotting, Western, Brain, Copper, Ditiocarb, Glutathione Transferase, Heme Oxygenase-1, Liver, Male, Mass Spectrometry, Myelin Sheath, Oxidation-Reduction, Oxidative Stress, Peripheral Nerves, Rats, Rats, Sprague-Dawley, Sciatic Nerve, Spinal Cord, Superoxide Dismutase, Superoxide Dismutase-1
Added May 27, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
N,N-diethyldithiocarbamate promotes oxidative stress prior to myelin structural changes and increases myelin copper content.
Viquez OM, Lai B, Ahn JH, Does MD, Valentine HL, Valentine WM
(2009) Toxicol Appl Pharmacol 239: 71-9
MeSH Terms: Animals, Blotting, Western, Brain, Copper, Ditiocarb, Glutathione Transferase, Heme Oxygenase (Decyclizing), Isoenzymes, Lipid Peroxidation, Male, Microscopy, Fluorescence, Myelin Sheath, Oxidative Stress, Proteasome Endopeptidase Complex, Protein Carbonylation, Rats, Rats, Sprague-Dawley, Sciatic Nerve, Spinal Cord, Superoxide Dismutase, Superoxide Dismutase-1
Added May 27, 2014
0 Communities
2 Members
0 Resources
21 MeSH Terms
Nitrogen substituent polarity influences dithiocarbamate-mediated lipid oxidation, nerve copper accumulation, and myelin injury.
Valentine HL, Viquez OM, Amarnath K, Amarnath V, Zyskowski J, Kassa EN, Valentine WM
(2009) Chem Res Toxicol 22: 218-26
MeSH Terms: Animals, Copper, Demyelinating Diseases, Ditiocarb, Ethylenebis(dithiocarbamates), Lipid Peroxidation, Male, Malondialdehyde, Mass Spectrometry, Myelin Sheath, Nitrogen, Oxidative Stress, Peripheral Nerves, Rats, Rats, Sprague-Dawley, Sarcosine, Thiocarbamates
Added May 27, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Copper accumulation and lipid oxidation precede inflammation and myelin lesions in N,N-diethyldithiocarbamate peripheral myelinopathy.
Viquez OM, Valentine HL, Amarnath K, Milatovic D, Valentine WM
(2008) Toxicol Appl Pharmacol 229: 77-85
MeSH Terms: Animals, Brain, Chelating Agents, Chromatography, High Pressure Liquid, Copper, Demyelinating Diseases, Disease Models, Animal, Ditiocarb, Immunoglobulin G, Lipid Peroxidation, Liver, Macrophage Activation, Macrophages, Male, Malondialdehyde, Mass Spectrometry, Oxidative Stress, Rats, Rats, Sprague-Dawley, Sciatic Nerve, Tibial Nerve
Added May 27, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
ESR techniques for the detection of nitric oxide in vivo as an index of endothelial function.
Fink B, Dikalov S, Fink N
(2006) Pharmacol Rep 58 Suppl: 8-15
MeSH Terms: Adrenergic beta-Antagonists, Animals, Aorta, Carbazoles, Cardiovascular Diseases, Carvedilol, Cattle, Cells, Cultured, Colloids, Ditiocarb, Electron Spin Resonance Spectroscopy, Endothelial Cells, Endothelium, Vascular, Ferrous Compounds, Hemoglobins, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Middle Aged, Nitric Oxide, Nitric Oxide Donors, Nitric Oxide Synthase Type III, Nitroglycerin, Propanolamines, Reactive Oxygen Species, Stress, Mechanical
Added February 17, 2016
0 Communities
1 Members
0 Resources
28 MeSH Terms
Peripheral nerve protein expression and carbonyl content in N,N-diethlydithiocarbamate myelinopathy.
Viquez OM, Valentine HL, Friedman DB, Olson SJ, Valentine WM
(2007) Chem Res Toxicol 20: 370-9
MeSH Terms: Animals, Chromatography, High Pressure Liquid, Databases, Factual, Demyelinating Diseases, Ditiocarb, Electrophoresis, Polyacrylamide Gel, Fluoresceins, Fluorescent Dyes, Globins, Immunoassay, Immunohistochemistry, Male, Nerve Tissue Proteins, Neural Networks, Computer, Neural Pathways, Oxidative Stress, Peripheral Nervous System, Rats, Rats, Sprague-Dawley, Sciatic Nerve, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Weight Gain
Added May 27, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
N,N-diethyldithiocarbamate produces copper accumulation, lipid peroxidation, and myelin injury in rat peripheral nerve.
Tonkin EG, Valentine HL, Milatovic DM, Valentine WM
(2004) Toxicol Sci 81: 160-71
MeSH Terms: Alcohol Deterrents, Animals, Chelating Agents, Chromatography, High Pressure Liquid, Copper, Diet, Disulfiram, Ditiocarb, Gas Chromatography-Mass Spectrometry, Histocytochemistry, Isoprostanes, Lipid Peroxidation, Liver, Liver Function Tests, Male, Muscle, Skeletal, Myelin Sheath, Neuromuscular Junction, Peripheral Nerves, Rats, Rats, Sprague-Dawley, Silver Staining, Spectrophotometry, Atomic, Tissue Distribution, Weight Gain
Added May 27, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms
Parenteral N,N-diethyldithiocarbamate produces segmental demyelination in the rat that is not dependent on cysteine carbamylation.
Tonkin EG, Valentine HL, Zimmerman LJ, Valentine WM
(2003) Toxicol Appl Pharmacol 189: 139-50
MeSH Terms: Animals, Body Weight, Chelating Agents, Chromatography, High Pressure Liquid, Cysteine, Demyelinating Diseases, Ditiocarb, Globins, Infusion Pumps, Implantable, Infusions, Parenteral, Male, Neurofilament Proteins, Peripheral Nerves, Rats, Rats, Sprague-Dawley
Added May 27, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Inhibition of copper-zinc superoxide dismutase induces cell growth, hypertrophic phenotype, and apoptosis in neonatal rat cardiac myocytes in vitro.
Siwik DA, Tzortzis JD, Pimental DR, Chang DL, Pagano PJ, Singh K, Sawyer DB, Colucci WS
(1999) Circ Res 85: 147-53
MeSH Terms: Animals, Animals, Newborn, Apoptosis, Cardiomegaly, Cell Division, Cell Membrane, Cells, Cultured, Chelating Agents, Ditiocarb, Gene Expression Regulation, Enzymologic, Hypertrophy, In Situ Nick-End Labeling, In Vitro Techniques, Muscle Fibers, Skeletal, Myocardium, Oxidative Stress, Phenotype, Rats, Superoxide Dismutase, Superoxides
Added March 5, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms