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Results: 1 to 4 of 4

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DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3.
Borza CM, Bolas G, Bock F, Zhang X, Akabogu FC, Zhang MZ, de Caestecker M, Yang M, Yang H, Lee E, Gewin L, Fogo AB, McDonald WH, Zent R, Pozzi A
(2022) JCI Insight 7:
MeSH Terms: Acute Kidney Injury, Animals, Cell Line, Cells, Cultured, Discoidin Domain Receptor 1, Female, Fibrosis, Gene Expression Regulation, Inflammation, Kidney Tubules, Proximal, Male, Mice, Mice, Knockout, Phosphorylation, Proto-Oncogene Proteins c-bcr, RNA, STAT3 Transcription Factor, Signal Transduction
Added December 27, 2021
0 Communities
1 Members
0 Resources
18 MeSH Terms
The Extracellular Matrix Receptor Discoidin Domain Receptor 1 Regulates Collagen Transcription by Translocating to the Nucleus.
Chiusa M, Hu W, Liao HJ, Su Y, Borza CM, de Caestecker MP, Skrypnyk NI, Fogo AB, Pedchenko V, Li X, Zhang MZ, Hudson BG, Basak T, Vanacore RM, Zent R, Pozzi A
(2019) J Am Soc Nephrol 30: 1605-1624
MeSH Terms: Actins, Acute Kidney Injury, Animals, Biological Transport, Cell Line, Cell Nucleus, Chromatin, Collagen Type I, Collagen Type IV, Discoidin Domain Receptor 1, Humans, Kidney Tubules, Proximal, Male, Mice, Myosin Heavy Chains, Nuclear Localization Signals, Retinoblastoma-Binding Protein 4, SEC Translocation Channels, Transcription, Genetic
Added May 10, 2020
0 Communities
1 Members
0 Resources
19 MeSH Terms
Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis.
Borza CM, Su Y, Tran TL, Yu L, Steyns N, Temple KJ, Skwark MJ, Meiler J, Lindsley CW, Hicks BR, Leitinger B, Zent R, Pozzi A
(2017) Matrix Biol 57-58: 258-271
MeSH Terms: Acute Kidney Injury, Angiotensins, Animals, Binding Sites, Collagen Type IV, Discoidin Domain Receptor 1, Epithelial Cells, Gene Expression Regulation, Humans, Kidney Glomerulus, Male, Mice, Mice, Knockout, Nephrectomy, Nephritis, Protein Binding, Signal Transduction, Ureter, Ureteral Obstruction
Added March 26, 2017
1 Communities
2 Members
1 Resources
19 MeSH Terms
Discoidin domain receptors in disease.
Borza CM, Pozzi A
(2014) Matrix Biol 34: 185-92
MeSH Terms: Animals, Cell Movement, Cell Proliferation, Discoidin Domain Receptor 1, Discoidin Domain Receptors, Extracellular Matrix, Fibrosis, Humans, Inflammation, Mice, Receptor Protein-Tyrosine Kinases, Receptors, Mitogen, Signal Transduction
Added February 24, 2014
0 Communities
2 Members
1 Resources
13 MeSH Terms