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Exploring the molecular determinants of substrate-selective inhibition of cyclooxygenase-2 by lumiracoxib.
Windsor MA, Valk PL, Xu S, Banerjee S, Marnett LJ
(2013) Bioorg Med Chem Lett 23: 5860-4
MeSH Terms: Animals, Binding Sites, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Diclofenac, Endocannabinoids, Mice, Molecular Docking Simulation
Added March 7, 2014
0 Communities
2 Members
0 Resources
8 MeSH Terms
Diclofenac enables unprecedented week-long microneedle-enhanced delivery of a skin impermeable medication in humans.
Brogden NK, Banks SL, Crofford LJ, Stinchcomb AL
(2013) Pharm Res 30: 1947-55
MeSH Terms: Administration, Cutaneous, Adult, Anti-Inflammatory Agents, Non-Steroidal, Diclofenac, Drug Delivery Systems, Female, Humans, Male, Microinjections, Naltrexone, Narcotic Antagonists, Needles, Skin Absorption, Young Adult
Added September 18, 2013
0 Communities
1 Members
0 Resources
14 MeSH Terms
Diclofenac delays micropore closure following microneedle treatment in human subjects.
Brogden NK, Milewski M, Ghosh P, Hardi L, Crofford LJ, Stinchcomb AL
(2012) J Control Release 163: 220-9
MeSH Terms: Administration, Cutaneous, Adult, Anti-Inflammatory Agents, Non-Steroidal, Cyclooxygenase Inhibitors, Diclofenac, Dielectric Spectroscopy, Female, Humans, Male, Microinjections, Middle Aged, Needles, Porosity, Skin, Transdermal Patch, Young Adult
Added September 18, 2013
0 Communities
1 Members
0 Resources
16 MeSH Terms
Cardiovascular risks of nonsteroidal antiinflammatory drugs in patients after hospitalization for serious coronary heart disease.
Ray WA, Varas-Lorenzo C, Chung CP, Castellsague J, Murray KT, Stein CM, Daugherty JR, Arbogast PG, García-Rodríguez LA
(2009) Circ Cardiovasc Qual Outcomes 2: 155-63
MeSH Terms: Aged, Anti-Inflammatory Agents, Non-Steroidal, Cardiovascular Diseases, Celecoxib, Cohort Studies, Coronary Artery Disease, Cyclooxygenase 2 Inhibitors, Diclofenac, Female, Follow-Up Studies, Hospitalization, Humans, Ibuprofen, Incidence, Lactones, Male, Middle Aged, Myocardial Infarction, Naproxen, Outpatients, Pyrazoles, Retrospective Studies, Risk Factors, Stroke, Sulfonamides, Sulfones, Tennessee
Added January 20, 2015
0 Communities
1 Members
0 Resources
27 MeSH Terms
Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.
Blobaum AL, Marnett LJ
(2007) J Biol Chem 282: 16379-90
MeSH Terms: Amino Acid Substitution, Animals, Cyclooxygenase 1, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Diclofenac, Humans, Kinetics, Male, Membrane Proteins, Mice, Models, Molecular, Mutation, Missense, Protein Binding, Protein Structure, Tertiary, Sheep, Time Factors
Added March 5, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Randomised controlled trial of the onset of analgesic efficacy of dexketoprofen and diclofenac in lower limb injury.
Leman P, Kapadia Y, Herington J
(2003) Emerg Med J 20: 511-3
MeSH Terms: Acute Disease, Administration, Oral, Adult, Analgesics, Diclofenac, Double-Blind Method, Female, Humans, Ketoprofen, Leg Injuries, Male, Pain, Prospective Studies, Statistics, Nonparametric, Treatment Outcome, Tromethamine
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385.
Rowlinson SW, Kiefer JR, Prusakiewicz JJ, Pawlitz JL, Kozak KR, Kalgutkar AS, Stallings WC, Kurumbail RG, Marnett LJ
(2003) J Biol Chem 278: 45763-9
MeSH Terms: Animals, Anti-Inflammatory Agents, Non-Steroidal, Arachidonic Acid, Arginine, Binding, Competitive, Cell Line, Crystallography, X-Ray, Cyclooxygenase 2, Diclofenac, Dose-Response Relationship, Drug, Enzyme Inhibitors, Insecta, Isoenzymes, Mice, Models, Chemical, Models, Molecular, Mutagenesis, Site-Directed, Mutation, Piroxicam, Prostaglandin-Endoperoxide Synthases, Protein Binding, Serine, Sulfonamides, Time Factors, Tyrosine
Added March 5, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms
Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes.
Yamazaki H, Inoue K, Chiba K, Ozawa N, Kawai T, Suzuki Y, Goldstein JA, Guengerich FP, Shimada T
(1998) Biochem Pharmacol 56: 243-51
MeSH Terms: Amino Acid Substitution, Aryl Hydrocarbon Hydroxylases, Catalysis, Cytochrome P-450 CYP2C9, Cytochrome P-450 Enzyme System, DNA, Diclofenac, Flurbiprofen, Heterozygote, Humans, Hydroxylation, Oxidation-Reduction, Polymorphism, Genetic, RNA, Stereoisomerism, Steroid 16-alpha-Hydroxylase, Steroid Hydroxylases, Warfarin
Added May 26, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms