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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 14

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Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2'-deoxyguanosine by Human DNA Polymerase η.
Patra A, Zhang Q, Guengerich FP, Egli M
(2016) J Biol Chem 291: 24304-24313
MeSH Terms: Bacterial Proteins, Crystallography, X-Ray, DNA, DNA Polymerase beta, DNA-Directed DNA Polymerase, Deoxycytosine Nucleotides, Humans, Sulfolobus solfataricus, Thymine Nucleotides
Added March 14, 2018
0 Communities
1 Members
0 Resources
9 MeSH Terms
Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase ι.
Choi JY, Patra A, Yeom M, Lee YS, Zhang Q, Egli M, Guengerich FP
(2016) J Biol Chem 291: 21063-21073
MeSH Terms: Amino Acid Substitution, Crystallography, X-Ray, DNA-Directed DNA Polymerase, Deoxycytosine Nucleotides, Humans, Hydrogen Bonding, Kinetics, Magnesium, Manganese, Mutation, Missense, Protein Domains
Added March 14, 2018
0 Communities
1 Members
0 Resources
11 MeSH Terms
Elucidation of kinetic mechanisms of human translesion DNA polymerase κ using tryptophan mutants.
Zhao L, Pence MG, Eoff RL, Yuan S, Fercu CA, Guengerich FP
(2014) FEBS J 281: 4394-410
MeSH Terms: Amino Acid Substitution, Catalytic Domain, DNA Adducts, DNA-Directed DNA Polymerase, Deoxycytosine Nucleotides, Diphosphates, Humans, Kinetics, Mutagenesis, Site-Directed, Protein Binding
Added January 20, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
Structural basis for proficient incorporation of dTTP opposite O6-methylguanine by human DNA polymerase iota.
Pence MG, Choi JY, Egli M, Guengerich FP
(2010) J Biol Chem 285: 40666-72
MeSH Terms: Bacterial Proteins, Base Pairing, Catalytic Domain, DNA, DNA Polymerase I, DNA Polymerase beta, DNA-Directed DNA Polymerase, Deoxycytosine Nucleotides, Geobacillus stearothermophilus, Guanine, Humans, Hydrogen Bonding, Kinetics, Structure-Activity Relationship, Sulfolobus, Thymine Nucleotides
Added March 7, 2014
0 Communities
2 Members
0 Resources
16 MeSH Terms
Effect of N2-guanyl modifications on early steps in catalysis of polymerization by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W.
Zhang H, Guengerich FP
(2010) J Mol Biol 395: 1007-18
MeSH Terms: Amino Acid Substitution, Archaeal Proteins, Base Sequence, Catalytic Domain, DNA Adducts, DNA Polymerase beta, DNA Replication, DNA, Archaeal, Deoxycytosine Nucleotides, Kinetics, Molecular Structure, Mutagenesis, Site-Directed, Nucleic Acid Conformation, Protein Conformation, Recombinant Proteins, Spectrometry, Fluorescence, Sulfolobus solfataricus
Added March 7, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Versatility of Y-family Sulfolobus solfataricus DNA polymerase Dpo4 in translesion synthesis past bulky N2-alkylguanine adducts.
Zhang H, Eoff RL, Kozekov ID, Rizzo CJ, Egli M, Guengerich FP
(2009) J Biol Chem 284: 3563-76
MeSH Terms: Archaeal Proteins, DNA Adducts, DNA Polymerase beta, DNA Replication, DNA, Archaeal, Deoxycytosine Nucleotides, Kinetics, Protein Conformation, Sulfolobus solfataricus
Added March 7, 2014
0 Communities
3 Members
0 Resources
9 MeSH Terms
Kinetic analysis of translesion synthesis opposite bulky N2- and O6-alkylguanine DNA adducts by human DNA polymerase REV1.
Choi JY, Guengerich FP
(2008) J Biol Chem 283: 23645-55
MeSH Terms: DNA Adducts, Deoxycytosine Nucleotides, Guanine, Humans, Kinetics, Nuclear Proteins, Nucleotidyltransferases, Recombinant Proteins, Substrate Specificity
Added March 26, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Translesion synthesis across bulky N2-alkyl guanine DNA adducts by human DNA polymerase kappa.
Choi JY, Angel KC, Guengerich FP
(2006) J Biol Chem 281: 21062-21072
MeSH Terms: Baculoviridae, Binding Sites, Catalysis, DNA Adducts, DNA Damage, DNA, Complementary, DNA-Directed DNA Polymerase, Deoxycytosine Nucleotides, Guanine, Humans, Kinetics, Models, Chemical, Oligonucleotides, Time Factors
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Efficient and high fidelity incorporation of dCTP opposite 7,8-dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA polymerase Dpo4.
Zang H, Irimia A, Choi JY, Angel KC, Loukachevitch LV, Egli M, Guengerich FP
(2006) J Biol Chem 281: 2358-72
MeSH Terms: 8-Hydroxy-2'-Deoxyguanosine, Base Sequence, Chromatography, Liquid, DNA, DNA Primers, DNA-Directed DNA Polymerase, Deoxycytosine Nucleotides, Deoxyguanosine, Dose-Response Relationship, Drug, Escherichia coli, Frameshift Mutation, Kinetics, Mass Spectrometry, Models, Molecular, Molecular Sequence Data, Protein Binding, Sulfolobus solfataricus, Time Factors, X-Ray Diffraction
Added March 5, 2014
0 Communities
2 Members
0 Resources
19 MeSH Terms
Wobble dC.dA pairing 5' to the cationic guanine N7 8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 adduct: implications for nontargeted AFB1 mutagenesis.
Giri I, Stone MP
(2003) Biochemistry 42: 7023-34
MeSH Terms: Aflatoxin B1, Base Composition, Base Pair Mismatch, Base Sequence, Cations, DNA Adducts, Deoxyadenine Nucleotides, Deoxycytosine Nucleotides, Guanine, Hydrogen-Ion Concentration, Intercalating Agents, Models, Molecular, Nuclear Magnetic Resonance, Biomolecular, Nucleic Acid Conformation, Nucleic Acid Heteroduplexes, Oligodeoxyribonucleotides, Protons, Structure-Activity Relationship
Added May 29, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms