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Results: 1 to 3 of 3

Publication Record


Drug-induced long QT syndrome.
Kannankeril P, Roden DM, Darbar D
(2010) Pharmacol Rev 62: 760-81
MeSH Terms: Animals, Delayed Rectifier Potassium Channels, Drug-Related Side Effects and Adverse Reactions, Humans, Long QT Syndrome, Risk Factors, Torsades de Pointes
Show Abstract · Added June 26, 2014
The drug-induced long QT syndrome is a distinct clinical entity that has evolved from an electrophysiologic curiosity to a centerpiece in drug regulation and development. This evolution reflects an increasing recognition that a rare adverse drug effect can profoundly upset the balance between benefit and risk that goes into the prescription of a drug by an individual practitioner as well as the approval of a new drug entity by a regulatory agency. This review will outline how defining the central mechanism, block of the cardiac delayed-rectifier potassium current I(Kr), has contributed to defining risk in patients and in populations. Models for studying risk, and understanding the way in which clinical risk factors modulate cardiac repolarization at the molecular level are discussed. Finally, the role of genetic variants in modulating risk is described.
0 Communities
1 Members
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7 MeSH Terms
A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cells.
Fridlyand LE, Jacobson DA, Kuznetsov A, Philipson LH
(2009) Biophys J 96: 3126-39
MeSH Terms: Action Potentials, Adenosine Triphosphate, Animals, Calcium, Calcium Channels, L-Type, Calcium Signaling, Cell Membrane, Computer Simulation, Delayed Rectifier Potassium Channels, Glucose, Insulin-Secreting Cells, Mice, Mice, Knockout, Models, Neurological, Patch-Clamp Techniques, Potassium, Potassium Channels, Voltage-Gated, Shab Potassium Channels, Sodium, Tetraethylammonium, Time
Show Abstract · Added February 12, 2015
We examined the ionic mechanisms mediating depolarization-induced spike activity in pancreatic beta-cells. We formulated a Hodgkin-Huxley-type ionic model for the action potential (AP) in these cells based on voltage- and current-clamp results together with measurements of Ca(2+) dynamics in wild-type and Kv2.1 null mouse islets. The model contains an L-type Ca(2+) current, a "rapid" delayed-rectifier K(+) current, a small slowly-activated K(+) current, a Ca(2+)-activated K(+) current, an ATP-sensitive K(+) current, a plasma membrane calcium-pump current and a Na(+) background current. This model, coupled with an equation describing intracellular Ca(2+) homeostasis, replicates beta-cell AP and Ca(2+) changes during one glucose-induced spontaneous spike, the effects of blocking K(+) currents with different inhibitors, and specific complex spike in mouse islets lacking Kv2.1 channels. The currents with voltage-independent gating variables can also be responsible for burst behavior. Original features of this model include new equations for L-type Ca(2+) current, assessment of the role of rapid delayed-rectifier K(+) current, and Ca(2+)-activated K(+) currents, demonstrating the important roles of the Ca(2+)-pump and background currents in the APs and bursts. This model provides acceptable fits to voltage-clamp, AP, and Ca(2+) concentration data based on in silico analysis.
0 Communities
1 Members
0 Resources
21 MeSH Terms
Cellular basis of drug-induced torsades de pointes.
Roden DM
(2008) Br J Pharmacol 154: 1502-7
MeSH Terms: Anti-Arrhythmia Agents, Delayed Rectifier Potassium Channels, Drug-Related Side Effects and Adverse Reactions, Electrophysiology, Humans, Long QT Syndrome, Risk Factors, Torsades de Pointes
Show Abstract · Added March 24, 2020
Striking QT prolongation and the morphologically distinctive ventricular tachycardia torsades de pointes can occur in up to 5% of patients treated with certain antiarrhythmic drugs. This adverse drug reaction also occurs, albeit far less frequently, during therapy with a range of drugs not used for cardiovascular indications; examples include certain antibiotics, antipsychotics and antihistamines. The common mechanism for drug-induced torsades de pointes is inhibition of a specific repolarizing potassium current, I(Kr). The key question facing clinicians, regulators and those who develop drugs is why torsades de pointes only occurs in some patients exposed to I(Kr) block. This paper reviews the clinical, cellular, molecular and genetic features of the arrhythmia that may provide an answer to this question and proposes future studies in this area.
0 Communities
1 Members
0 Resources
MeSH Terms