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Protective Role of Spermidine in Colitis and Colon Carcinogenesis.
Gobert AP, Latour YL, Asim M, Barry DP, Allaman MM, Finley JL, Smith TM, McNamara KM, Singh K, Sierra JC, Delgado AG, Luis PB, Schneider C, Washington MK, Piazuelo MB, Zhao S, Coburn LA, Wilson KT
(2022) Gastroenterology 162: 813-827.e8
MeSH Terms: Adenomatous Polyposis Coli Protein, Animals, Azoxymethane, Carcinogenesis, Colitis, Colitis, Ulcerative, Colon, Colonic Neoplasms, Dextran Sulfate, Gastrointestinal Microbiome, Gene Expression Regulation, Humans, Intestinal Mucosa, Male, Mice, Oxidoreductases Acting on CH-NH Group Donors, Precancerous Conditions, Protective Factors, RNA, Messenger, Severity of Illness Index, Spermidine, Weight Loss, alpha-Defensins
Added November 18, 2021
0 Communities
1 Members
0 Resources
23 MeSH Terms
Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease.
Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M'Koma AE
(2017) PLoS One 12: e0179710
MeSH Terms: Biomarkers, Biopsy, Colitis, Ulcerative, Crohn Disease, Diagnosis, Differential, Gene Expression Profiling, Humans, Immunohistochemistry, Inflammatory Bowel Diseases, Intestinal Mucosa, Muramidase, Proctocolectomy, Restorative, Retrospective Studies, alpha-Defensins
Added March 14, 2018
0 Communities
1 Members
0 Resources
14 MeSH Terms
Multiplexed molecular descriptors of pressure ulcers defined by imaging mass spectrometry.
Taverna D, Nanney LB, Pollins AC, Sindona G, Caprioli R
(2011) Wound Repair Regen 19: 734-44
MeSH Terms: Adolescent, Adult, Dermis, Epidermis, Female, Humans, Immunohistochemistry, Male, Middle Aged, Phospholipids, Pressure Ulcer, Principal Component Analysis, Proteins, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Thymosin, Wound Healing, Young Adult, alpha-Defensins
Added May 28, 2014
0 Communities
2 Members
0 Resources
18 MeSH Terms
Gastric cancer-specific protein profile identified using endoscopic biopsy samples via MALDI mass spectrometry.
Kim HK, Reyzer ML, Choi IJ, Kim CG, Kim HS, Oshima A, Chertov O, Colantonio S, Fisher RJ, Allen JL, Caprioli RM, Green JE
(2010) J Proteome Res 9: 4123-30
MeSH Terms: Biomarkers, Tumor, Biopsy, Case-Control Studies, Defensins, Gastroscopy, Humans, Leukocyte L1 Antigen Complex, Models, Statistical, Proteomics, Sensitivity and Specificity, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Stomach Neoplasms
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
PGE2 decreases reactivity of human platelets by activating EP2 and EP4.
Smith JP, Haddad EV, Downey JD, Breyer RM, Boutaud O
(2010) Thromb Res 126: e23-9
MeSH Terms: Adult, Blood Platelets, Dinoprostone, Epididymal Secretory Proteins, Female, Humans, Male, Platelet Aggregation, beta-Defensins
Added December 21, 2013
0 Communities
2 Members
0 Resources
9 MeSH Terms
Suppression of hepatic glucose production by human neutrophil alpha-defensins through a signaling pathway distinct from insulin.
Liu HY, Collins QF, Moukdar F, Zhuo D, Han J, Hong T, Collins S, Cao W
(2008) J Biol Chem 283: 12056-63
MeSH Terms: Animals, Blood Glucose, Cell Line, Tumor, Cell Separation, Forkhead Box Protein O1, Forkhead Transcription Factors, Gluconeogenesis, Glucose, Hepatocytes, Humans, Insulin, Liver, Mice, Phosphorylation, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins pp60(c-src), Rats, Rats, Zucker, Signal Transduction, Transcription, Genetic, alpha-Defensins
Added July 23, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
A molecular signature of gastric metaplasia arising in response to acute parietal cell loss.
Nozaki K, Ogawa M, Williams JA, Lafleur BJ, Ng V, Drapkin RI, Mills JC, Konieczny SF, Nomura S, Goldenring JR
(2008) Gastroenterology 134: 511-22
MeSH Terms: Animals, Atrophy, Basic Helix-Loop-Helix Transcription Factors, Carrier Proteins, Cell Cycle Proteins, Cell Transformation, Neoplastic, Chief Cells, Gastric, DNA-Binding Proteins, Epididymal Secretory Proteins, Fetal Proteins, Gastric Fundus, Gastric Mucosa, Gastrins, Humans, Intercellular Signaling Peptides and Proteins, Intrinsic Factor, Metaplasia, Mice, Mice, Inbred C57BL, Mice, Knockout, Microtubule-Associated Proteins, Minichromosome Maintenance Complex Component 3, Mucins, Muscle Proteins, Nuclear Proteins, Parietal Cells, Gastric, Peptides, Precancerous Conditions, Stomach Neoplasms, Trefoil Factor-2, beta-Defensins
Added October 7, 2013
1 Communities
2 Members
0 Resources
31 MeSH Terms
Mosquito phenoloxidase and defensin colocalize in melanization innate immune responses.
Hillyer JF, Christensen BM
(2005) J Histochem Cytochem 53: 689-98
MeSH Terms: Aedes, Animals, Defensins, Escherichia coli, Female, Immunohistochemistry, Melanins, Micrococcus luteus, Microscopy, Electron, Transmission, Monophenol Monooxygenase
Added February 5, 2016
0 Communities
1 Members
0 Resources
10 MeSH Terms
Age-associated mortality in immune challenged mosquitoes (Aedes aegypti) correlates with a decrease in haemocyte numbers.
Hillyer JF, Schmidt SL, Fuchs JF, Boyle JP, Christensen BM
(2005) Cell Microbiol 7: 39-51
MeSH Terms: Aging, Animals, Colony Count, Microbial, Culicidae, Defensins, Disease Models, Animal, Escherichia coli, Gene Expression Regulation, Hemocytes, Insect Proteins, Models, Biological, Phagocytes, RNA, Messenger
Added February 5, 2016
0 Communities
1 Members
0 Resources
13 MeSH Terms
Bacterial vaginosis, vaginal fluid neutrophil defensins, and preterm birth.
Balu RB, Savitz DA, Ananth CV, Hartmann KE, Miller WC, Thorp JM, Heine RP
(2003) Obstet Gynecol 101: 862-8
MeSH Terms: Adult, Case-Control Studies, Defensins, Enzyme-Linked Immunosorbent Assay, Female, Humans, Neutrophils, Obstetric Labor, Premature, Pregnancy, Pregnancy Complications, Infectious, Proportional Hazards Models, Vagina, Vaginosis, Bacterial
Added March 5, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms