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Rate-limiting steps in cytochrome P450 catalysis.
Guengerich FP
(2002) Biol Chem 383: 1553-64
MeSH Terms: Catalysis, Computer Simulation, Cytochrome P-450 Enzyme System, Dealkylation, Ferrous Compounds, Hemeproteins, Humans, Kinetics, Oxidation-Reduction, Thermodynamics
Added May 26, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Oxidation of methoxyphenethylamines by cytochrome P450 2D6. Analysis of rate-limiting steps.
Guengerich FP, Miller GP, Hanna IH, Sato H, Martin MV
(2002) J Biol Chem 277: 33711-9
MeSH Terms: Catalysis, Cytochrome P-450 CYP2D6, Dealkylation, Hydrogen Peroxide, Kinetics, NADP, Oxidation-Reduction, Tyramine
Added March 5, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation.
Tateishi T, Krivoruk Y, Ueng YF, Wood AJ, Guengerich FP, Wood M
(1996) Anesth Analg 82: 167-72
MeSH Terms: Analgesics, Opioid, Animals, Antibodies, Antibody Specificity, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Dealkylation, Enzyme Inhibitors, Erythromycin, Fentanyl, Humans, Kinetics, Liver, Microsomes, Liver, Mixed Function Oxygenases, Norpregnenes, Rabbits, Sufentanil, Troleandomycin
Added March 5, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Biotransformation of tritiated fentanyl in human liver microsomes. Monitoring metabolism using phenylacetic acid and 2-phenylethanol.
Tateishi T, Wood AJ, Guengerich FP, Wood M
(1995) Biochem Pharmacol 50: 1921-4
MeSH Terms: Analgesics, Opioid, Biotransformation, Dealkylation, Drug Monitoring, Fentanyl, Humans, In Vitro Techniques, Microsomes, Liver, Phenylacetates, Phenylethyl Alcohol, Tritium
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Interpretations of cytochrome P450 mechanisms from kinetic studies.
Guengerich FP, Bell LC, Okazaki O
(1995) Biochimie 77: 573-80
MeSH Terms: Animals, Catalysis, Cations, Cytochrome P-450 Enzyme System, Data Interpretation, Statistical, Dealkylation, Deuterium, Ferrous Compounds, Free Radicals, Hemeproteins, Homeostasis, Kinetics, Protons, Rats, Tritium
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.
Yun CH, Okerholm RA, Guengerich FP
(1993) Drug Metab Dispos 21: 403-9
MeSH Terms: Contraceptives, Oral, Cytochrome P-450 CYP2E1, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Dealkylation, Humans, Hydroxylation, In Vitro Techniques, Microsomes, Liver, Mixed Function Oxygenases, NADP, Norpregnenes, Oxidation-Reduction, Stereoisomerism, Terfenadine
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Radical cation intermediates in N-dealkylation reactions.
Guengerich FP, Okazaki O, Seto Y, Macdonald TL
(1995) Xenobiotica 25: 689-709
MeSH Terms: Animals, Cations, Cytochrome P-450 Enzyme System, Dealkylation, Free Radicals, Humans
Added March 5, 2014
0 Communities
1 Members
0 Resources
6 MeSH Terms