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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 12

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Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer.
Dosch AR, Dai X, Reyzer ML, Mehra S, Srinivasan S, Willobee BA, Kwon D, Kashikar N, Caprioli R, Merchant NB, Nagathihalli NS
(2020) Mol Cancer Res 18: 623-631
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Pancreatic Ductal, Dasatinib, Deoxycytidine, Disease Models, Animal, ErbB Receptors, Erlotinib Hydrochloride, Female, Humans, Mice, Mice, Nude, Pancreatic Neoplasms, Protein Kinase Inhibitors, STAT3 Transcription Factor, Signal Transduction, Stromal Cells, Survival Analysis, Xenograft Model Antitumor Assays, src-Family Kinases
Added March 3, 2020
0 Communities
1 Members
0 Resources
20 MeSH Terms
Cardiovascular care of patients with chronic myeloid leukemia (CML) on tyrosine kinase inhibitor (TKI) therapy.
Barber MC, Mauro MJ, Moslehi J
(2017) Hematology Am Soc Hematol Educ Program 2017: 110-114
MeSH Terms: Aged, Dasatinib, Female, Fusion Proteins, bcr-abl, Humans, Hypertension, Pulmonary, Imidazoles, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Male, Middle Aged, Protein Kinase Inhibitors, Pyridazines, Pyrimidines
Added April 22, 2018
0 Communities
1 Members
0 Resources
13 MeSH Terms
Tyrosine Kinase Inhibitor-Associated Cardiovascular Toxicity in Chronic Myeloid Leukemia.
Moslehi JJ, Deininger M
(2015) J Clin Oncol 33: 4210-8
MeSH Terms: Aniline Compounds, Antineoplastic Agents, Cardiovascular System, Clinical Trials as Topic, Dasatinib, Fusion Proteins, bcr-abl, Humans, Hypertension, Imatinib Mesylate, Imidazoles, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Molecular Targeted Therapy, Nitriles, Protein Kinase Inhibitors, Pyridazines, Pyrimidines, Quinolines
Added March 6, 2016
0 Communities
1 Members
0 Resources
17 MeSH Terms
LYN-activating mutations mediate antiestrogen resistance in estrogen receptor-positive breast cancer.
Schwarz LJ, Fox EM, Balko JM, Garrett JT, Kuba MG, Estrada MV, González-Angulo AM, Mills GB, Red-Brewer M, Mayer IA, Abramson V, Rizzo M, Kelley MC, Meszoely IM, Arteaga CL
(2014) J Clin Invest 124: 5490-502
MeSH Terms: Amino Acid Substitution, Aminopyridines, Animals, Breast Neoplasms, Dasatinib, Drug Resistance, Neoplasm, Drug Synergism, Estrogen Receptor Modulators, Female, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Humans, Mice, Mice, Nude, Morpholines, Mutation, Missense, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, Protein Kinase Inhibitors, Pyrimidines, Receptors, Estrogen, Thiazoles, Xenograft Model Antitumor Assays, src Homology Domains, src-Family Kinases
Added February 16, 2016
0 Communities
2 Members
0 Resources
26 MeSH Terms
Global phosphotyrosine proteomics identifies PKCδ as a marker of responsiveness to Src inhibition in colorectal cancer.
McKinley ET, Liu H, McDonald WH, Luo W, Zhao P, Coffey RJ, Hanks SK, Manning HC
(2013) PLoS One 8: e80207
MeSH Terms: Animals, Antigens, CD, Antigens, Neoplasm, Biomarkers, Tumor, Caco-2 Cells, Cell Adhesion Molecules, Cell Line, Tumor, Colorectal Neoplasms, Dasatinib, HCT116 Cells, Humans, Mice, Mice, Nude, Neoplasm Proteins, Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases, Phosphoric Monoester Hydrolases, Phosphotyrosine, Protein Kinase C-delta, Protein Kinase Inhibitors, Proteome, Proteomics, Pyrimidines, Receptor-Like Protein Tyrosine Phosphatases, Class 5, Thiazoles, src-Family Kinases
Added March 20, 2014
1 Communities
5 Members
0 Resources
25 MeSH Terms
Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth.
Yeung CL, Ngo VN, Grohar PJ, Arnaldez FI, Asante A, Wan X, Khan J, Hewitt SM, Khanna C, Staudt LM, Helman LJ
(2013) Oncogene 32: 5429-38
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Cell Line, Tumor, Cell Proliferation, Dasatinib, Humans, Mice, Mice, Inbred NOD, Mice, SCID, Neoplasm Transplantation, Nuclear Proteins, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-yes, Pyrimidines, RNA Interference, RNA, Small Interfering, Rhabdomyosarcoma, Signal Transduction, Thiazoles
Added September 3, 2013
0 Communities
2 Members
0 Resources
19 MeSH Terms
Phase II trial of dasatinib for patients with acquired resistance to treatment with the epidermal growth factor receptor tyrosine kinase inhibitors erlotinib or gefitinib.
Johnson ML, Riely GJ, Rizvi NA, Azzoli CG, Kris MG, Sima CS, Ginsberg MS, Pao W, Miller VA
(2011) J Thorac Oncol 6: 1128-31
MeSH Terms: Adenocarcinoma, Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Dasatinib, Drug Resistance, Neoplasm, ErbB Receptors, Erlotinib Hydrochloride, Female, Gefitinib, Humans, Lung Neoplasms, Male, Middle Aged, Protein Kinase Inhibitors, Pyrimidines, Quinazolines, Thiazoles, Treatment Outcome
Added March 24, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Combined blockade of Src kinase and epidermal growth factor receptor with gemcitabine overcomes STAT3-mediated resistance of inhibition of pancreatic tumor growth.
Nagaraj NS, Washington MK, Merchant NB
(2011) Clin Cancer Res 17: 483-93
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Cell Line, Tumor, Cell Movement, Dasatinib, Deoxycytidine, Drug Resistance, Neoplasm, ErbB Receptors, Erlotinib Hydrochloride, Female, Humans, Inhibitory Concentration 50, Mice, Mice, Nude, Pancreatic Neoplasms, Protein Kinase Inhibitors, Pyrimidines, Quinazolines, STAT3 Transcription Factor, Thiazoles, Xenograft Model Antitumor Assays, src-Family Kinases
Added June 14, 2013
0 Communities
3 Members
0 Resources
22 MeSH Terms
Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis.
Nagaraj NS, Smith JJ, Revetta F, Washington MK, Merchant NB
(2010) Mol Cancer Ther 9: 2322-32
MeSH Terms: Apoptosis, Cell Cycle, Cell Line, Tumor, Cell Proliferation, Dasatinib, Disease Progression, Humans, Neoplasm Metastasis, Pancreas, Pancreatic Neoplasms, Protein Kinase Inhibitors, Pyrimidines, Signal Transduction, Thiazoles, Tumor Stem Cell Assay, src-Family Kinases
Added June 14, 2013
0 Communities
3 Members
0 Resources
16 MeSH Terms
Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells.
Faley SL, Copland M, Wlodkowic D, Kolch W, Seale KT, Wikswo JP, Cooper JM
(2009) Lab Chip 9: 2659-64
MeSH Terms: Annexin A5, Apoptosis, Cell Division, Cell Survival, Cells, Cultured, Dasatinib, Hematopoietic Stem Cells, Humans, Kinetics, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Microfluidics, Microscopy, Fluorescence, Protein Kinase Inhibitors, Protein-Tyrosine Kinases, Pyrimidines, Signal Transduction, Thiazoles
Added May 29, 2014
1 Communities
2 Members
0 Resources
17 MeSH Terms